본문 바로가기
KERD
논문KCI 등재

단일기관에서 전산을 통해 수집된 자발적 소아 약물유해반응 보고사례의 분석

Pediatric adverse drug reactions collected by an electronic reporting system in a single tertiary university hospital

박주현|김영호|조현주|한혜원|유진호|윤지선|정주원|김태범|김재연|홍수종|이 은|박근미
대한 소아알레르기 호흡기학회 (The Korean Academy Of Pediatric Allergy And Respiratory Disease)|2016.09|Allergy Asthma & Respiratory Disease (알레르기 천식 호흡기질환)|제4권 제5호|pp. 354-359|DOI http://dx.doi.org/10.4168/aard.2016.4.5.354

2

조회

0

다운로드

7

인용

0

참고문헌

키워드

ChildAntibioticsAdverse drug reactionTramadolSedatives
주제분류소아과학

초록

Purpose: The incidence of adverse drug reactions (ADRs) is increasing. However, studies on the prevalence of ADRs in children are rare. The aim of this study was to investigate the causative drugs and clinical features of ADRs for children in a tertiary university hospital of Korea. Methods: We retrospectively collected ADRs by a computerized self-reporting system in Asan Medical Center. ADRs of children under the age 18 were collected from January 2005 to August 2015, and we analyzed only ADRs containing current symptoms among total ADR data. Results: A total of 1,408 ADR cases were reported, There were 764 male (54.3%) and 644 female patients (45.7%), and the mean age was 11.5±5.8 years (range, 0–18 years). Antibiotics (n=479, 34.0%) were the most common causative drugs, followed by tramadol (n=173, 12.3%), nonsteroidal anti-inflammatory agents (NSAIDs) and acetylsalicylic acid (n=103, 7.3%), narcotics (n=91, 6.5%), antineoplastics (n=87, 6.2%), and sedatives (n=82, 5.8%). The most common clinical features were skin manifestations (n=500, 34.4%). Gastrointestinal symptoms (n=435, 29.9%) were the second most common clinical features, followed by neuropsychiatric symptoms (n=155, 10.7%) and respiratory symptoms (n=123, 8.5%). Among antibiotics, glycopeptides (n=110, 23.0%), third-generation cephalosporins (n=83, 17.3%), and penicillin/ß-lactamase inhibitors (n=60, 12.7%) were the most frequently reported causative drugs. Conclusion: Antibiotics were the most reported common causative drugs of ADRs in children, followed by tramadol, NSAID, and narcortics. Compared with adults, the prevalence of contrast medium-induced ADR was lower in children with a higher prevalence of sedative-associated ADR. Greater attention to possible ADRs in children is needed among medical personnel.

Abstract

Purpose: The incidence of adverse drug reactions (ADRs) is increasing. However, studies on the prevalence of ADRs in children are rare. The aim of this study was to investigate the causative drugs and clinical features of ADRs for children in a tertiary university hospital of Korea. Methods: We retrospectively collected ADRs by a computerized self-reporting system in Asan Medical Center. ADRs of children under the age 18 were collected from January 2005 to August 2015, and we analyzed only ADRs containing current symptoms among total ADR data. Results: A total of 1,408 ADR cases were reported, There were 764 male (54.3%) and 644 female patients (45.7%), and the mean age was 11.5±5.8 years (range, 0–18 years). Antibiotics (n=479, 34.0%) were the most common causative drugs, followed by tramadol (n=173, 12.3%), nonsteroidal anti-inflammatory agents (NSAIDs) and acetylsalicylic acid (n=103, 7.3%), narcotics (n=91, 6.5%), antineoplastics (n=87, 6.2%), and sedatives (n=82, 5.8%). The most common clinical features were skin manifestations (n=500, 34.4%). Gastrointestinal symptoms (n=435, 29.9%) were the second most common clinical features, followed by neuropsychiatric symptoms (n=155, 10.7%) and respiratory symptoms (n=123, 8.5%). Among antibiotics, glycopeptides (n=110, 23.0%), third-generation cephalosporins (n=83, 17.3%), and penicillin/ß-lactamase inhibitors (n=60, 12.7%) were the most frequently reported causative drugs. Conclusion: Antibiotics were the most reported common causative drugs of ADRs in children, followed by tramadol, NSAID, and narcortics. Compared with adults, the prevalence of contrast medium-induced ADR was lower in children with a higher prevalence of sedative-associated ADR. Greater attention to possible ADRs in children is needed among medical personnel.

참고문헌 (22)

  1. "International drug monitoring: the role of national centres. Report of a WHO meeting", World Health Organ Tech Rep Ser, 498, pp.1~25 (1972)
  2. Lazarou J, "Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies", JAMA, 279, pp.1200~1205 (1998)
  3. Pirmohamed M, "Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients", BMJ, 329, pp.15~19 (2004)
  4. Bowman L, "Incidence of adverse drug reactions in adult medical inpatients", Can J Hosp Pharm, 47, pp.209~216 (1994)
  5. Lundkvist J, "Pharmacoeconomics of adverse drug reactions", Fundam Clin Pharmacol, 18, pp.275~280 (2004)
  6. Moore TJ, "Serious adverse drug events reported to the Food and Drug Administration, 1998-2005", Arch Intern Med, 167, pp.1752~1759 (2007)
  7. Demoly P, "Epidemiology of drug allergy", Curr Opin Allergy Clin Immunol, 1, pp.305~310 (2001)
  8. Pirmohamed M, "Adverse drug reactions", BMJ, 316, pp.1295~1298 (1998)
  9. 김명현, "단일 3차 의료기관에서 수집한 약물 유해반응의 양상 분석", 천식 및 알레르기, 28(1), pp.35~39 (2008), 대한천식알레르기학회
  10. 김민강, "단일기관에서 전산을 통해 수집된 자발적 약물유해반응 보고사례들의 분석", 대한내과학회지, 77(5), pp.601~609 (2009), 대한내과학회
  11. 김정은, "노인 입원환자에서 발생한 약물유해반응의 특성", 천식 및 알레르기, 30(3), pp.216~221 (2010), 대한천식알레르기학회
  12. 최정희, "단일 3차 의료기관에서 약물 이상 반응의 빈도", 대한내과학회지, 67(3), pp.290~296 (2004), 대한내과학회
  13. 류성윤, "단일 대학병원 약물유해반응의 보고 및 임상양상", 천식 및 알레르기, 31(3), pp.184~191 (2011), 대한천식알레르기학회
  14. Kos M, "Satisfaction with pharmacotherapy for approved and off-label indications: a Delphi study", Ann Pharmacother, 39, pp.649~654 (2005)
  15. 금민정, "원내 소아 환자에서 보고된 약물 부작용 사례 분석", 병원약사회지, 28(3), pp.253~261 (2011), 한국병원약사회
  16. Coté CJ, "Adverse sedation events in pediatrics: analysis of medications used for sedation", Pediatrics, 106, pp.633~644 (2000)
  17. Malviya S, "Prolonged recovery and delayed side effects of sedation for diagnostic imaging studies in children", Pediatrics, 105, pp.E42~ (2000)
  18. Kim HM, "Analysis of adverse events reporting patterns and signal detection for pediatric patients in the Korean spontaneous reporting data", Korean Soc Pharmacoepidemiol Risk Manage, 5, pp.40~45 (2012)
  19. Ferrajolo C, "Pediatric drug safety surveillance in Italian pharmacovigilance network: an overview of adverse drug reactions in the years 2001 - 2012", Expert Opin Drug Saf, 13(Suppl 1), pp.S9~S20 (2014)
  20. 박근미, "소아에서 비스테로이드항염증제 약물알레르기 4례", Allergy Asthma & Respiratory Diseases, 21(4), pp.344~349 (2011), 대한 소아알레르기 호흡기학회
  21. Mirakian R, "BSACI guidelines for the management of drug allergy", Clin Exp Allergy, 39, pp.43~61 (2009)
  22. 정지현, "소아 약물유해반응 보고 사례 분석", 병원약사회지, 30(2), pp.108~118 (2013), 한국병원약사회

관련 논문AI추천

단일 대학병원의 지역의약품안전센터에 보고된 소아청소년의 약물유해반응 분석김도우, 남영희, 이영석, 정진아, 최윤창대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2018 · 제6권 제5호원내 소아 환자에서 보고된 약물 부작용 사례 분석고종희, 금민정, 김성은, 김수현, 박은혜, 석현주한국병원약사회 · 병원약사회지2011 · 제28권 제3호약물이상반응 감시 현황: 단일기관 10년 자료 분석강동윤, 강혜련, 김현화, 문미라, 박가윤, 박수빈, 이주연, 조상헌, 조윤숙대한내과학회 · 대한내과학회지2021 · 제96권 제4호소아 약물유해반응 보고 사례 분석김정태, 유기연, 정지현한국병원약사회 · 병원약사회지2013 · 제30권 제2호약물유해반응의 진단과 대처법; 실제 진료 현장에서정진아대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2023 · 제11권 제2호단일 대학병원 약물유해반응의 보고 및 임상양상고영일, 김민석, 김하나, 류성윤, 류시현, 박승환, 신희영, 천승우대한천식알레르기학회 · 천식 및 알레르기2011 · 제31권 제3호

이 간행물의 다른 논문 (11건)

소아에서의 약물유해반응 감시의 임상적 의의정은희pp. 309-310국내외 호흡기 및 인체 마이크로바이옴 연구최성미, 조상헌, 이하나pp. 311-320천식과 만성폐쇄성폐질환에서 마이크로바이옴 연구강혜련, 이진국, 정지예, 조상헌, 김병근pp. 321-327요인별 기관지천식에 대한 범주예측모형 개발오재원, 유광하, 나위진, 윤혜숙, 김주화, 장윤석, 김현희, 최영진pp. 328-339중증 천식발작 회복 후 임상 경과 - 제3보박명수, 최인선, 은정남, 홍지윤pp. 340-345
원문 보기