호산구성 기관지염과 천식의 객담 내 IL-5과 IL-13: 기도 과민성과의 연관성
IL-13 And IL-5 in Induced Sputum in Patients with Eosinophilic Bronchitis and Asthma: an Association with Airway Hyperresponsiveness
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Abstract
Background: Experimental studies on asthma have indicated that IL-13 induces airway hyperreactivity (AHR). However, it remains unproven that IL-13 is responsible for AHR of asthmatics. Eosinophilic bronchitis (EB) shows normal airway responsiveness despite eosinophilic airway inflammation with similar severity to that of asthma. Objective: This study evaluated the role of IL-13 in asthma by comparing the sputum IL-5 and IL-13 levels in both groups. Method: IL-5 and IL-13 were assayed in sputum and culture supernatants of peripheral blood mononuclear cells from 22 asthmatics, 12 EB patients, and 11 normal controls. Result: IL-13 level was higher in asthmatics than EB patients or normal controls (P<.05). IL-5 level was similar in asthmatics and EB patients, who had significantly higher IL-5 level than normal controls. Sputum IL-13, not IL-5, is inversely correlated with PC20 methacholine value in asthmatics (r=-0.484, P=.02). IL-13 production by peripheral blood mononuclear cells was significantly higher in asthmatics than in EB patients. Conclusion: These findings suggested that IL-13 may contribute to the pathogenic mechanism of AHR in asthmatic patients.
참고문헌 (35)
- "Global initiative for asthma Global strategy for asthma management and prevention Nhlbi", Who workshop report National Institutes of Health, 1995, ~
- "Th2 like bronchoalveolar T-lymphocyte population in atopic asthma", pp.298~304
- "Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge", pp.1083~93
- "eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma", pp.1403~9
- "Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma", pp.935~40
- "IL-5 is required for the development of antigen-induced airways eosinophilia", pp.1132~41
- "Eosinophil recruitment to the airway nerves", pp.211~8
- "Effects of an interleukin-5 blocking monoclonal antibody on eosinophils", pp.2144~8
- "eosinophilic bronchitis without asthma", pp.1346~8
- "Development of chronic airway obstruction in patients with eosinophilic bronchitis"
- "Mast cell infiltration of airway smooth muscle in asthma", pp.1699~705
- "Th2 cytokine expression in bronchoalveolar lavage fluid T lymphocyte and bronchial submucosa is a feature of asthma and eosinophilic bronchitis", pp.899~905
- "Compararison of airway immunopathology of eosinophilic bronchitis and asthma", pp.528~32
- "A novel T cell-regulated mechanism modulating allergen- induced airways hyperreactivity in BALB", c mice independently of IL-4 and IL-5, jimmunol1998;161, 1501~9
- "The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells", pp.202~8
- "Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of il-5 and eotaxin", pp.522~30
- "Pulmonary expression of interleukin-13 causes inflammation", pp.779~88
- "central mediator of allergic asthma", pp.2258~13 61
- "Requirement for IL-13 independently of IL-4 in experimental asthma", pp.2261~3
- "IL-13 induced chemokine responses in the lung role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling", pp.2953~62
- "IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells a role for ERK", pp.~53
- "IL-13 expression at the sites of allergen challenge in patients with asthma", pp.2688~94
- "Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma", pp.657~65
- "Association of interleukin-5 and eotaxin with acute exacerbation of asthma", pp.283~90
- "Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease", pp.225~44
- "Hargreave FE Histamine and methacholine inhalation tests Sweden Astra Draco AB" (1994)
- "Interleukin-8 secretion and neutophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma", (rzila mz), pp.769~74
- "Use of induced sputum cell counts to investigate airway inflammation in asthma", pp.25~9
- "Indices of airway inflammation in induced sputum reproducibility and validity of cell and fluid-phase measurements", pp.308~17
- "Critical role for IL-13 in the development of allergen-induced airway hyperreactivity", pp.4668~75
- "Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma", dolga(v gm), pp.885~9
- "Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells", pp.141~8
- "CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4", pp.1032~40
- "Frequency and characterization of antigen-specific IL-4- and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects", pp.811~9, Prussin C
- "Chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus potential implication in eosinophil recruitment", pp.586~92
