본문 바로가기
KERD
논문KCI 등재

호산구성 기관지염과 천식의 객담 내 IL-5과 IL-13: 기도 과민성과의 연관성

IL-13 And IL-5 in Induced Sputum in Patients with Eosinophilic Bronchitis and Asthma: an Association with Airway Hyperresponsiveness

2

조회

0

다운로드

0

인용

0

참고문헌

주제분류임상병리학

초록

Abstract

Background: Experimental studies on asthma have indicated that IL-13 induces airway hyperreactivity (AHR). However, it remains unproven that IL-13 is responsible for AHR of asthmatics. Eosinophilic bronchitis (EB) shows normal airway responsiveness despite eosinophilic airway inflammation with similar severity to that of asthma. Objective: This study evaluated the role of IL-13 in asthma by comparing the sputum IL-5 and IL-13 levels in both groups. Method: IL-5 and IL-13 were assayed in sputum and culture supernatants of peripheral blood mononuclear cells from 22 asthmatics, 12 EB patients, and 11 normal controls. Result: IL-13 level was higher in asthmatics than EB patients or normal controls (P<.05). IL-5 level was similar in asthmatics and EB patients, who had significantly higher IL-5 level than normal controls. Sputum IL-13, not IL-5, is inversely correlated with PC20 methacholine value in asthmatics (r=-0.484, P=.02). IL-13 production by peripheral blood mononuclear cells was significantly higher in asthmatics than in EB patients. Conclusion: These findings suggested that IL-13 may contribute to the pathogenic mechanism of AHR in asthmatic patients.

참고문헌 (35)

  1. "Global initiative for asthma Global strategy for asthma management and prevention Nhlbi", Who workshop report National Institutes of Health, 1995, ~
  2. "Th2 like bronchoalveolar T-lymphocyte population in atopic asthma", pp.298~304
  3. "Cytokine profiles of BAL T cells and T-cell clones obtained from human asthmatic airways after local allergen challenge", pp.1083~93
  4. "eosinophil progenitor mobilization and eosinophil CCR3 expression in asthma", pp.1403~9
  5. "Evidence for systemic rather than pulmonary effects of interleukin-5 administration in asthma", pp.935~40
  6. "IL-5 is required for the development of antigen-induced airways eosinophilia", pp.1132~41
  7. "Eosinophil recruitment to the airway nerves", pp.211~8
  8. "Effects of an interleukin-5 blocking monoclonal antibody on eosinophils", pp.2144~8
  9. "eosinophilic bronchitis without asthma", pp.1346~8
  10. "Development of chronic airway obstruction in patients with eosinophilic bronchitis"
  11. "Mast cell infiltration of airway smooth muscle in asthma", pp.1699~705
  12. "Th2 cytokine expression in bronchoalveolar lavage fluid T lymphocyte and bronchial submucosa is a feature of asthma and eosinophilic bronchitis", pp.899~905
  13. "Compararison of airway immunopathology of eosinophilic bronchitis and asthma", pp.528~32
  14. "A novel T cell-regulated mechanism modulating allergen- induced airways hyperreactivity in BALB", c mice independently of IL-4 and IL-5, jimmunol1998;161, 1501~9
  15. "The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells", pp.202~8
  16. "Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of il-5 and eotaxin", pp.522~30
  17. "Pulmonary expression of interleukin-13 causes inflammation", pp.779~88
  18. "central mediator of allergic asthma", pp.2258~13 61
  19. "Requirement for IL-13 independently of IL-4 in experimental asthma", pp.2261~3
  20. "IL-13 induced chemokine responses in the lung role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling", pp.2953~62
  21. "IL-13 and IL-4 cause eotaxin release in human airway smooth muscle cells a role for ERK", pp.~53
  22. "IL-13 expression at the sites of allergen challenge in patients with asthma", pp.2688~94
  23. "Elevated expression of messenger ribonucleic acid encoding IL-13 in the bronchial mucosa of atopic and nonatopic subjects with asthma", pp.657~65
  24. "Association of interleukin-5 and eotaxin with acute exacerbation of asthma", pp.283~90
  25. "Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease", pp.225~44
  26. "Hargreave FE Histamine and methacholine inhalation tests Sweden Astra Draco AB" (1994)
  27. "Interleukin-8 secretion and neutophil recruitment accompanies induced sputum eosinophil activation in children with acute asthma", (rzila mz), pp.769~74
  28. "Use of induced sputum cell counts to investigate airway inflammation in asthma", pp.25~9
  29. "Indices of airway inflammation in induced sputum reproducibility and validity of cell and fluid-phase measurements", pp.308~17
  30. "Critical role for IL-13 in the development of allergen-induced airway hyperreactivity", pp.4668~75
  31. "Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma", dolga(v gm), pp.885~9
  32. "Direct effects of interleukin-13 on signaling pathways for physiological responses in cultured human airway smooth muscle cells", pp.141~8
  33. "CysLT1 receptor upregulation by TGF-beta and IL-13 is associated with bronchial smooth muscle cell proliferation in response to LTD4", pp.1032~40
  34. "Frequency and characterization of antigen-specific IL-4- and IL-13-producing basophils and T cells in peripheral blood of healthy and asthmatic subjects", pp.811~9, Prussin C
  35. "Chemokines and interleukin-5 in bronchial lavage fluid from patients with status asthmaticus potential implication in eosinophil recruitment", pp.586~92

관련 논문AI추천

이 간행물의 다른 논문 (13건)