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간접흡연이 소아 천식 환자의 유도 객담 내의 Vascular Endothelial Growth Factor 농도에 미치는 영향

The Effect of Environmental Smoking on Vascular Endothelial Growth Factor Levels in Induced Sputum of the Asthmatic Children

정지태|김형진
대한 소아알레르기 호흡기학회 (The Korean Academy Of Pediatric Allergy And Respiratory Disease)|2007.06|Allergy Asthma & Respiratory Disease (알레르기 천식 호흡기질환)|제17권 제2호|pp. 137-148

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참고문헌

주제분류소아과학

초록

목 적 : VEGF는 천식 환자의 기도 점막에 증가되어 있다. 소아 천식 환자들은 부모의 흡연을 통한 ETS에 빈번히 노출된다. 본 저자들은 ETS 가 소아 천식 환자들의 유발객담 내 VEGF 농도에 미치는 영향을 조사하였다. 방 법 : 고려대학교병원 소아과에 급성 천식 악화로 입원한 69명의 소아 천식 환자들을 연구 대상으로 하였다. 설문지를 통하여 ETS 기왕력에 대한 조사를 하였다. 환자들의 유도 객담 내 VEGF 농도는 ELISA 방법으로 측정하였으며, 객담 ECP, 혈청 IgE, 혈청 ECP 농도도 측정하여 ETS군과 non-ETS군을 비교하였다. 결 과 : 유도 객담 내 VEGF 농도는 ETS군에서 non-ETS군에 비하여 더 높게 측정되었다. 소아 천식 환자의 객담 VEGF와 객담 ECP의 농도는 양의 상관 관계를 보이며, 이 상관 관계는 Non-ETS 군에서 더욱 명확하게 나타났다. 그러나 객담 VEGF 농도는 혈청 ECP 농도, 혈청 총 IgE, 말초 혈액 총 호산구 수와는 상관관계를 보이지 않았다. 결 론 : 소아 천식 환자들이 가족 흡연에 노출되어지면 객담 VEGF 농도가 증가하는 것으로 나타났다. 소아 천식 환자가 ETS에 노출이 되면 천식의 증상이 악화되는데 이는 증가된 객담 VEGF 농도와 관련이 있다고 생각된다.

Abstract

Purpose : Vascular endothelial growth factor (VEGF) is highly expressed in the airways of asthmatic patients. Asthmatic children are commonly exposed to parental smoking. We investigated the effect of environmental tobacco smoking (ETS) on VEGF levels in induced sputum of asthmatic children. Methods : Sixty-nine asthmatic children were enrolled, who were hospitalized in the Pediatric Department of Korea University Hospital for acute asthma exacerbation. We interviewed their parents to assess ETS history with a questionnaire. We measured VEGF levels in induced sputum from asthmatic children by enzyme-linked immunosorbent assay, and we also measured the concentrations of sputum ECP by radioimmunoassay. We compared sputum levels of VEGF and ECP between an ETS group and a non-ETS group. Results : Of the 69 cases, 45 were in the non-ETS group and 24 were in the ETS group. The ETS group showed higher sputum VEGF levels than did the non-ETS group (P=0.001). Serum IgE levels were not related to the sputum levels of VEGF in the ETS group, and there was no association between serum levels of ECP and sputum levels of VEGF. Conclusion : When asthmatic children were exposed to family smoking, higher levels of VEGF were measured in their sputum. It seems that environmental smoking aggravates allergic airway inflammation. We suggest that parents of asthmatic children should make all efforts to stop smoking.

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