소아에서 Acetaminophen에 의한 고정 약진 1례
A Case of Fixed Drug Eruption Caused by Acetaminophen in a Child
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초록
고정 약진은 주로 항생제에 많이 일어나는 반응이며 그 외에 barbiturates, phenolphthalein 등과 같은 약물이 고정약진을 잘 유발하는 약물로 알려져 있다. 드물게 보고되고 있는 acetaminophen에 의한 고정 약진을 소아에서 경구 유발시험으로 진단하였기에 이를 보고 하는 바이다.
Abstract
Fixed drug eruption (FDE) is an eruption, which recurs at the same site or sites on each administration of the causative drug, and heals with residual hyperpigmentation. FDE is caused by many drugs, barbiturates, tetracyclines, sulfonamide, and phenolphthalein. Salicylate and nonsteroidal anti-inflammatory drugs (NSAIDs) also cause FDE, but acetaminophen does so only rarely. A 9-year-old girl presented with a 3-year-history of symptomatic pigmented macules on her face, abdomen, and extremities. The eruption was first appeared three years ago, which was when she took medicine after she was discharged following suspicions of Kawasaki disease. Thereafter, she had the same eruption on the same sites when she took medicine for common colds including acetaminophen and ibuprofen. The oral challenge provocation test for ibuprofen was negative, whereas for acetaminophen it was positive. We report a rare case of FDE due to acetaminophen with clinical findings and results of oral challenge test.
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