소아 마이코플라스마 폐렴의 다양한 임상 양상에 연관된 요인들
Factors associated with various clinical manifestations of Mycoplasma pneumonia in children
1
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Purpose: Mycoplasma pneumonia (MP) is a major cause of community-acquired pneumonia in children and young adults. We aimed to investigate the factors that may influence on the clinical manifestations of MP in children. Methods: A total of 109 admitted children from October 2011 to February 2012 were prospectively enrolled with physical examination and laboratory tests (complete blood count, C-reactive protein [CRP], and particle agglutinin assay). The diagnosis of MP was made when there was an infiltration on the chest X-ray and the particle agglutination test was once over 1:640 or showed 4-fold increase in serial tests. They were grouped by age, fever duration after treatment, presence of pleural effusion and wheezing. Results: Preschool children showed shorter duration of fever (P=0.001), more wheezing (P<0.001), lower segmented neutrophil (P<0.001), and lower CRP levels (P=0.004) compared to schoolchildren. Prolonged fever (>3 days) and pleural effusion were developed in children with higher CRP (P=0.018 and P=0.007). Wheezing has been developed in children with younger age (P=0.007). Conclusion: Younger age was a risk factor to develop wheezing in MP and prolonged fever and pleural effusion were more likely to develop in children with higher CRP.
Abstract
Purpose: Mycoplasma pneumonia (MP) is a major cause of community-acquired pneumonia in children and young adults. We aimed to investigate the factors that may influence on the clinical manifestations of MP in children. Methods: A total of 109 admitted children from October 2011 to February 2012 were prospectively enrolled with physical examination and laboratory tests (complete blood count, C-reactive protein [CRP], and particle agglutinin assay). The diagnosis of MP was made when there was an infiltration on the chest X-ray and the particle agglutination test was once over 1:640 or showed 4-fold increase in serial tests. They were grouped by age, fever duration after treatment, presence of pleural effusion and wheezing. Results: Preschool children showed shorter duration of fever (P=0.001), more wheezing (P<0.001), lower segmented neutrophil (P<0.001), and lower CRP levels (P=0.004) compared to schoolchildren. Prolonged fever (>3 days) and pleural effusion were developed in children with higher CRP (P=0.018 and P=0.007). Wheezing has been developed in children with younger age (P=0.007). Conclusion: Younger age was a risk factor to develop wheezing in MP and prolonged fever and pleural effusion were more likely to develop in children with higher CRP.
참고문헌 (22)
- Atkinson TP, "Epidemiology, clinical manifestations, pathogenesis and laboratory detection of Mycoplasma pneumoniae infections", FEMS Microbiol Rev, 32, pp.956~973 (2008)
- Lee KY, "Pediatric respiratory infections by Mycoplasma pneumoniae", Expert Rev Anti Infect Ther, 6, pp.509~521 (2008)
- 김진우, "국내소아에서 발생한 마이코플라스마 폐렴 메타분석", Korean Journal of Pediatrics, 52(3), pp.315~323 (2009), 대한소아과학회
- 이승현, "마이코플라즈마 폐렴의 임상 역학적 연구(1993-2003년)", Korean Journal of Pediatrics, 48(2), pp.154~157 (2005), 대한소아과학회
- Youn YS, "Difference of clinical features in childhood Mycoplasma pneumoniae pneumonia", BMC Pediatr, 10, pp.48~ (2010)
- 홍수종, "The Role of Mycoplasma pneumoniae Infection in Asthma", Allergy, Asthma & Immunology Research, 4(2), pp.59~61 (2012), 대한천식알레르기학회
- Hong JY, "Occurrence of Mycoplasma pneumoniae pneumonia in Seoul, Korea, from 1986 to 1995", J Korean Pediatr Soc, 40, pp.607~613 (1997)
- Nagayama Y, "Isolation of Mycoplasma pneumoniae from children with lower-respiratory-tract infections", J Infect Dis, 157, pp.911~917 (1988)
- Defilippi A, "Epidemiology and clinical features of Mycoplasma pneumoniae infection in children", Respir Med, 102, pp.1762~1768 (2008)
- 김경원, "국내 마이코플라스마와 클라미디아 감염 - 폐렴을 중심으로 -", Korean Journal of Pediatrics, 52(3), pp.277~282 (2009), 대한소아과학회
- You-Sook Youn, "Mycoplasma pneumoniae pneumonia in children", Korean Journal of Pediatrics, 55(2), pp.42~47 (2012), 대한소아과학회
- Xia Y, "Differences in the clinical features of Mycoplasma pneumoniae pneumonia among children of different ages", Zhongguo Dang Dai Er Ke Za Zhi, 15, pp.179~182 (2013)
- Lieberman D, "Atypical pathogen infection in adults with acute exacerbation of bronchial asthma", Am J Respir Crit Care Med, 167, pp.406~410 (2003)
- Esposito S, "Importance of acute Mycoplasma pneumoniae and Chlamydia pneumoniae infections in children with wheezing", Eur Respir J, 16, pp.1142~1146 (2000)
- 김경원, "인체 기관지 상피세포에서 Mycoplasma pneumoniae 감염에 의한천식 매개물질의 발현", Korean Journal of Pediatrics, 49(9), pp.977~982 (2006), 대한소아과학회
- Yang J, "Cytokines in Mycoplasma pneumoniae infections", Cytokine Growth Factor Rev, 15, pp.157~168 (2004)
- Lazaar AL, "Airway smooth muscle: a modulator of airway remodeling in asthma", J Allergy Clin Immunol, 116, pp.488~495 (2005)
- Lee CG, "Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung", Nat Med, 10, pp.1095~1103 (2004)
- 김진택, "Mycoplasma pneumoniae 감염의 검사실 진단", Allergy Asthma & Respiratory Diseases, 16(1), pp.23~25 (2006), 대한 소아알레르기 호흡기학회
- Waites KB, "New concepts of Mycoplasma pneumoniae infections in children", Pediatr Pulmonol, 36, pp.267~278 (2003)
- Chan PW, "Mycoplasma Pneumoniae infection in Malaysian children admitted with community acquired pneumonia", Southeast Asian J Trop Med Public Health, 32, pp.397~401 (2001)
- Kim NH, "Comparison of polymerase chain reaction and the indirect particle agglutination antibody test for the diagnosis of Mycoplasma pneumoniae pneumonia in children during two outbreaks", Pediatr Infect Dis J, 26, pp.897~903 (2007)