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소아 비염 환자에서 혈청 비타민 D 및 interleukin-31 수치와 알레르기비염 및 비알레르기비염과의 관계

Relationship of serum vitamin D and interleukin-31 levels to allergic or nonallergic rhinitis in children

김덕수|박문수|정혜림|심재원|심정연|박성준|소지은
대한 소아알레르기 호흡기학회 (The Korean Academy Of Pediatric Allergy And Respiratory Disease)|2018.01|Allergy Asthma & Respiratory Disease (알레르기 천식 호흡기질환)|제6권 제1호|pp. 41-46|DOI https://doi.org/10.4168/aard.2018.6.1.41

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키워드

Allergic rhinitisVitamin DNonallergic rhinitisInterleukin-3125-Hydroxyvitamin D
주제분류소아과학

초록

Purpose: Serum vitamin D (25-hydroxyvitamin D, 25[OH] D) and interleukin-31 (IL-31) are related to atopic dermatitis, but their relationship with allergic rhinitis is unclear. The purpose of this study was to compare the levels of serum IL-31 and 25 (OH) D between the allergic rhinitis (AR), nonallergic rhinitis (NAR), and control groups and to investigate the relationship between IL-31 and 25 (OH) D. Methods: We recruited 59 children with only rhinitis and 33 controls without any allergic diseases. Serum IL-31 and 25(OH) D levels were assayed using an enzyme-linked immunosorbent assay and high-performance liquid chromatography, respectively. The patients were considered to have atopic sensitization if the levels of serum specific IgE to inhalant allergens as assessed using immunoCAP were ≥0.35 IU/mL or if they tested positive for one or more allergens by the skin prick test. Results: Of children with rhinitis, 25 had nonatopy (NAR), and 34 children had atopy (AR). Serum 25(OH) D levels were significantly lower in the rhinitis group than in the control group, while there was no significant difference serum 25(OH) D levels between the AR and NAR groups. Children with rhinitis demonstrated higher serum IL-31 levels than controls; however, there was no difference in serum IL-31 levels between the AR and NAR groups. Serum 25(OH) D levels were inversely correlated with serum IL-31 levels and blood eosinophil counts. On the other hand, serum 25(OH) D levels were not correlated with total serum IgE levels. Conclusion: Serum 25(OH) D and IL-31 may play a role in the pathogenesis of rhinitis via mechanisms other than IgE-related pathway.

Abstract

Purpose: Serum vitamin D (25-hydroxyvitamin D, 25[OH] D) and interleukin-31 (IL-31) are related to atopic dermatitis, but their relationship with allergic rhinitis is unclear. The purpose of this study was to compare the levels of serum IL-31 and 25 (OH) D between the allergic rhinitis (AR), nonallergic rhinitis (NAR), and control groups and to investigate the relationship between IL-31 and 25 (OH) D. Methods: We recruited 59 children with only rhinitis and 33 controls without any allergic diseases. Serum IL-31 and 25(OH) D levels were assayed using an enzyme-linked immunosorbent assay and high-performance liquid chromatography, respectively. The patients were considered to have atopic sensitization if the levels of serum specific IgE to inhalant allergens as assessed using immunoCAP were ≥0.35 IU/mL or if they tested positive for one or more allergens by the skin prick test. Results: Of children with rhinitis, 25 had nonatopy (NAR), and 34 children had atopy (AR). Serum 25(OH) D levels were significantly lower in the rhinitis group than in the control group, while there was no significant difference serum 25(OH) D levels between the AR and NAR groups. Children with rhinitis demonstrated higher serum IL-31 levels than controls; however, there was no difference in serum IL-31 levels between the AR and NAR groups. Serum 25(OH) D levels were inversely correlated with serum IL-31 levels and blood eosinophil counts. On the other hand, serum 25(OH) D levels were not correlated with total serum IgE levels. Conclusion: Serum 25(OH) D and IL-31 may play a role in the pathogenesis of rhinitis via mechanisms other than IgE-related pathway.

참고문헌 (23)

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관련 논문AI추천

소아에서 혈청 25-hydroxyvitamin D와 알레르기비염의 연관성김경원, 김규언, 김민정, 김윤희, 김정윤, 박영아, 설인숙, 손명현, 윤서희대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2016 · 제4권 제6호아토피피부염 환아에서 interleukin-31 및 25-hydroxyvitamin D의 혈청 수치와 아토피피부염의 중증도와의 상관관계김덕수, 박문수, 심재원, 심정연, 양윤석, 이정원, 정혜림대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2015 · 제3권 제6호알레르겐 유무에 따른 아토피피부염 환아의 중증도와 혈중 25-hydroxyvitamin D3 농도와의 상관관계김성원, 성명순, 최광해, 최진욱, 황영진대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2015 · 제3권 제3호비타민 D 농도와 아토피피부염 환아의 중증도와의 상관관계김성원, 박종하, 성명순, 신영혜대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2014 · 제2권 제2호2세 이하 아토피피부염 환아에서 비타민 D 부족과 식품항원 감작의 연관성백종욱, 이소연, 이혜란, 황보준원대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2013 · 제1권 제3호두드러기 소아 환자에서의 흡입 및 식품항원 감작과비타민 D 관련성윤정원, 이신혜, 이정봉, 한만용대한 소아알레르기 호흡기학회 · Allergy Asthma & Respiratory Disease2017 · 제5권 제3호

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