소아 들깨알레르기에서 참깨 동시 감작과 교차반응성 연구
Perilla seed allergy in children: Cosensitization and cross-reactivity with sesame seed
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Purpose: Perilla seed (PS) is the most common cause of seed-induced anaphylaxis in Korean children, but the reports on PS allergy, including phenotype and cross-reactivity, are rare. The aim of this study is to assess the clinical characteristics of PS allergy and investigate cross-reactivity with sesame seed (SS). Methods: Through a retrospective medical record review, patients with clinical PS allergy were identified in a single tertiary hospital. Clinical characteristics of allergic reaction upon exposure to PS and SS, results of skin prick test (SPT) to PS and SS, and the levels of serum SS-specific immunoglobulin E (SS-sIgE) were investigated. Cross-reactivity between PS and SS was studied using IgE enzyme-linked immunosorbent assay (ELISA) inhibition. Results: The median age of 34 PS-allergic children was 41.5 months (range, 10 months to 12 years), and the proportion of anaphylaxis upon exposure to PS was 29.4% (n=10). The PS SPT was positive in 94.1% (n=32) with the median wheal size of 6.25 mm. Among PS-allergic children, the percentages of patients with positive symptoms, negative symptoms, and indeterminate symptoms upon exposure to SS were 8.8%, 41.2%, and 50%, respectively. Out of 14 PS-allergic children who were tolerant to SS, positive sensitization to SS was noticed in 78.6% by serum SS-sIgE, and 57.1% by SS SPT. Partial cross-reactivity between PS and SS was identified in IgE ELISA inhibition. Conclusion: This study reported the clinical profiles and SPT results in a relatively large number of PS-allergic children and identified the partial cross-reactivity between PS and SS for the first time.
Abstract
Purpose: Perilla seed (PS) is the most common cause of seed-induced anaphylaxis in Korean children, but the reports on PS allergy, including phenotype and cross-reactivity, are rare. The aim of this study is to assess the clinical characteristics of PS allergy and investigate cross-reactivity with sesame seed (SS). Methods: Through a retrospective medical record review, patients with clinical PS allergy were identified in a single tertiary hospital. Clinical characteristics of allergic reaction upon exposure to PS and SS, results of skin prick test (SPT) to PS and SS, and the levels of serum SS-specific immunoglobulin E (SS-sIgE) were investigated. Cross-reactivity between PS and SS was studied using IgE enzyme-linked immunosorbent assay (ELISA) inhibition. Results: The median age of 34 PS-allergic children was 41.5 months (range, 10 months to 12 years), and the proportion of anaphylaxis upon exposure to PS was 29.4% (n=10). The PS SPT was positive in 94.1% (n=32) with the median wheal size of 6.25 mm. Among PS-allergic children, the percentages of patients with positive symptoms, negative symptoms, and indeterminate symptoms upon exposure to SS were 8.8%, 41.2%, and 50%, respectively. Out of 14 PS-allergic children who were tolerant to SS, positive sensitization to SS was noticed in 78.6% by serum SS-sIgE, and 57.1% by SS SPT. Partial cross-reactivity between PS and SS was identified in IgE ELISA inhibition. Conclusion: This study reported the clinical profiles and SPT results in a relatively large number of PS-allergic children and identified the partial cross-reactivity between PS and SS for the first time.
참고문헌 (29)
- "Yield of oil crops from major statistics conducted by Ministry of Agriculture, Food and Rural Affairs" (2017)[URL]
- Patel A, "Hypersensitivities to sesame and other common edible seeds", Allergy, 71, pp.1405~1413 (2016)
- Jeong K, "A multicenter study on anaphylaxis caused by peanut, tree nuts, and seeds in children and adolescents", Allergy, 72, pp.507~510 (2017)
- .,
- Breiteneder H, "A classification of plant food allergens", J Allergy Clin Immunol, 113, pp.821~830 (2004)
- Leduc V, "Identification of oleosins as major allergens in sesame seed allergic patients", Allergy, 61, pp.349~356 (2006)
- Konstantinou GN, "The longest wheal diameter is the optimal measurement for the evaluation of skin prick tests", Int Arch Allergy Immunol, 151, pp.343~345 (2010)
- Teodorowicz M, "Immunological characterization of dutch sesame seed-allergic patients", Int Arch Allergy Immunol, 169, pp.13~22 (2016)
- Warren CM, "Prevalence and severity of sesame allergy in the United States", JAMA Netw Open, 2, pp.e199144~ (2019)
- Asero R, "Detection of 20 kDa and 32 kDa IgE-binding proteins as the major allergens in Italian sesame seed allergic patients", Eur Ann Allergy Clin Immunol, 46, pp.22~25 (2014)
- Jeong YY, "Two cases of anaphylaxis caused by perilla seed", J Allergy Clin Immunol, 117, pp.1505~1506 (2006)
- 송지은, "2세 남아에서 발견된 들깨 알레르기 1례", Allergy Asthma & Respiratory Disease, 19(1), pp.78~83 (2009), 대한 소아알레르기 호흡기학회
- 민선양, "들깨에 의한 아나필락시스 1예", 천식 및 알레르기, 26(1), pp.94~97 (2006), 대한천식알레르기학회
- Sokol K, "Prevalence and diagnosis of sesame allergy in children with IgE-mediated food allergy", Pediatr Allergy Immunol, 31, pp.214~218 (2020)
- Agne PS, "Sesame seed allergy in children", Eur Ann Allergy Clin Immunol, 36, pp.300~305 (2004)
- 정경욱, "Age- Based Causes and Clinical Characteristics of Immediate-Type Food Allergy in Korean Children", Allergy, Asthma & Immunology Research, 9(5), pp.423~430 (2017), 대한천식알레르기학회
- Mullins RJ, "Paediatric food allergy trends in a community-based specialist allergy practice, 1995-2006", Med J Aust, 186, pp.618~621 (2007)
- Dalal I, "The pattern of sesame sensitivity among infants and children", Pediatr Allergy Immunol, 14, pp.312~316 (2003)
- Lee E, "Pine nut allergy in Korean children : clinical characteristics and diagnostic values of specific IgE against pine nuts", Allergol Immunopathol(Madr), 46, pp.247~252 (2018)
- Eun Joo Lee, "Clinical and Laboratory Findings of Barley Allergy in Korean Children: a Single Hospital Based Retrospective Study", Journal of Korean Medical Science, 35(3), pp.1~10 (2020), 대한의학회[DOI]
- Kyujung Park, "Clinical and laboratory findings of childhood buckwheat allergy in a single tertiary hospital", Clinical and Experimental Pediatrics, 59(10), pp.402~407 (2016), 대한소아청소년과학회
- Stutius LM, "Characterizing the relationship between sesame, coconut, and nut allergy in children", Pediatr Allergy Immunol, 21, pp.1114~1118 (2010)
- Beyer K, "Identification of sesame seed allergens by 2-dimensional proteomics and Edman sequencing : seed storage proteins as common food allergens", J Allergy Clin Immunol, 110, pp.154~159 (2002)
- Beausoleil JL, "Late diagnosis of tree nut and sesame allergy in patients previously sensitized but tolerant to peanut", Ann Allergy Asthma Immunol, 97, pp.443~445 (2006)
- Asero R, "Allergenic similarities of 2S albumins", Allergy, 57, pp.62~63 (2002)
- Albunni BA, "Antibody cross-reactivity between proteins of Chia seed (Salvia hispanica L.) and other food allergens", J Agric Food Chem, 67, pp.7475~7484 (2019)
- Figueroa J, "Mustard allergy confirmed by double-blind placebo-controlled food challenges : clinical features and cross-reactivity with mugwort pollen and plant-derived foods", Allergy, 60, pp.48~55 (2005)
- Sirvent S, "nsLTP and profilin are allergens in mustard seeds : cloning, sequencing and recombinant production of Sin a 3 and Sin a 4", Clin Exp Allergy, 39, pp.1929~1936 (2009)
- Ehlers AM, "Sesame oleosins are minor allergens", Clin Transl Allergy, 9, pp.32~ (2019)