HLA-B*58:01 음성 환자에서 발생한 알로퓨리놀에 의한 스티븐스-존슨 증후군
Stevens-Johnson syndrome induced by allopurinol in a HLA-B*58:01–negative patient
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Abstract
Allopurinol-induced Stevens-Johnson syndrome (SJS) is a rare but severe reaction associated with the HLA-B*58:01 allele, especially in Asian populations. Most HLA-B*58:01–negative individuals do not develop severe cutaneous adverse reactions, such as SJS, which makes the case of this patient exceptionally uncommon. Here, we report the case of a patient with allopurinol-induced SJS who tested negative for HLA-B*58:01 genotyping. Despite preemptive HLA-B*58:01 genotyping, the patient developed SJS after initiating allopurinol therapy, suggesting the possible presence of nongenetic risk factors such as renal impairment and dosing. This case report emphasizes the importance of individualized therapy and careful monitoring, even in HLA-B*58:01–negative patients.