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Quantification of Metabolic Alterations of Dorsolateral Pre-Frontal Cortex in Depression SD Rat by MR Spectroscopy

최보영|홍관수|최치봉|홍승탁|박청수
한국자기공명학회 (Korean Magnetic Resonance Society)|2006.12|Journal of the Korean Magnetic Resonance Society|제10권 제2호|pp. 126-140

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Abstract

Purpose: Contrary to the human study, it has rarely investigated metabolic alterations in the dorsolateral prefrontal cortex (DLPFC) of depressed rats versus age- and sex-matched controls using proton magnetic resonance spectroscopy (MRS). Thus, the purpose of this research was to verify the feasibility of metabolic differences between the normal rat and the depression model rat. Materials and Methods: A homogeneous group of 20 SD male rats was used for MRI and in vivo 1H MRS. To induce a depressed status in SD rats, we performed the forced swimming test (FST). Using image-guide, water suppressed in vivo 1H MRS with 4.7 T MRI/MRS system, NAA/Cr and Cho/Cr ratios were mainly measured between depressed rats and normal subjects. Results: In depressed rats, increased Cho/Cr ratio was measured versus control subjects. However, no significant group effect for NAA/Cr was observed between case-control pairs. Discussion and Conclusions: The present 1H MRS study shows significant brain metabolic alterations of dorsolateral prefrontal cortex with experimental depressed status of SD rat induced by FST compared to normal subjects. This result provides new evidence that in vivo 1H MRS may be a useful modality for detecting localized functional neurochemical markers alterations in left DLPFC in SD rats

참고문헌 (29)

  1. "Magnetic resonance spectroscopy in schizophrenia: methodological issues and findings ？", 48, pp.357~368 (2000)
  2. "Anatomic and behavioral aspects of frontal-subcortical circuits.", 769, pp.1~13 (1995)
  3. "Morphometric methods for studying the prefrontal cortex in suicide victims and psychiatric patients.", 836, pp.253~268 (1997)
  4. "A neuroanatomic model for depression Progress in Neuro-Psycho-pharmacology & Biological Psychiatry 23", 23, pp.175~193 (1999)
  5. "From perception to action", 9, pp.213~221 (1999)
  6. "Dorsolateral prefrontal cortex dysfunction in the major psychoses; symptom or disease specificity Journal of Neurology", pp.1290~1294 (1993)
  7. "A test-retest study of cerebral blood flow during somatosensory stimulation in depressed patients with schizophrenia and major depression European Archives of Psychiatry and Clinical Neuroscience 242", pp.250~254 (1993)
  8. "Hypofrontality and negative symptoms in major depressive disorder.", 39, pp.608~612 (1998)
  9. "Hypercortisolemia and hippocampal changes in depression", pp.163~173 (1993)
  10. "Ventricular enlargement and caudate hyperdensity in elderly depressives Quantitative cerebral anatomy in depression Archives of General Psychiatry 50", pp.452 7~458 16
  11. "Neuropsychological and neuroimaging evidence for the involvement of the frontal lobes in depression.", 11, pp.115~122 (1997)
  12. "Atrophy and high intensity lesions", 22, pp.264~274 (2000)
  13. "Prefrontal cortical volume in childhood ？Conset major depression", 59, pp.173~179 (2002)
  14. "Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy.", 159, pp.630~636 (2002)
  15. "1H magnetic resonance spectroscopy study of dorsolateral prefrontal cortex in unipolar mood disorder patients", 138, pp.131~139 (2005), Psychiatry Research
  16. "Depression: a new animal model sensitive to antidepressant treatments.", 266, pp.730~732 (1997)
  17. "a new method for screening antidepressants in mice", pp.367~85 370 (1985)
  18. "The ability of local injection of 6-OHDA 7-DHT into the olfactory bulbs to mimic the effects of bilateral bulbectomy in the rat", pp.6 145~146 (1977)
  19. "Effects of olfactory bulbectomy and domicile on stress induced corticosterone release in the rat", pp.485~487 (1977)
  20. "localized in vivo adjustment of all first- and second-order shim coils Analysis of magnetic resonance spectra by mole percent Comparison to absolute units", pp.804 133~811 140
  21. "High resolution proton magnetic resonance spectroscopy of rabbit brain", ogi(t), pp.163~171 (1988)
  22. "Regional metabolite concentrations in human brain as determined by quantitative localized proton MRS", 39, pp.53~60 (1998)
  23. "a literature review of a compound prominent in 1H-NMR spectroscopic studies of brain", pp.23~31 (1989)
  24. "Age-dependent changes in localized proton and phosphorus MR spectroscopy of the brain", pp.509~176 515 (1990)
  25. "Cerebral metabolic alterations in normal aging and Alzheimer’s dementia detected by proton magnetic resonance spectroscopy" (1992)
  26. "The concentration of N-acetyl aspartate creatine", phosphocreatine and choline in different parts of the brain in adulthood and senium, 19921932, ~[DOI]
  27. "Proton spectroscopy of human brain effect of age and sex", pp.995~1004 (1994)
  28. "Quantitative measurements with localized 1H MR spectroscopy in children with Canavan’s disease", 6, pp.889~893 (1996)
  29. Ross B, "Clinical applications of magnetic resonance spectroscopy"

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