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안정상태 뇌 대사 활성도에 반영된 정신분열병 환자와 정상인에서의 감정이입과 기분인식 관련 뇌 영역

Empathy and Mood Awareness Reflected in the Resting-state Brain Metabolic Activity in the Patients with Schizophrenia and Normal Subjects

정영철|석정호|김재진|전지원|박해정|이종두|박일호
대한생물정신의학회 (The Korean Society Of Biological Psychiatry)|2007.05|생물정신의학 (Journal of Korean Society of Biological Psychiatry)|제14권 제2호|pp. 129-141

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키워드

감정이입·정서인식·정신분열병·안정상태·안와전두피질·PETEmpathyEmotional awarenessSchizophreniaResting-stateorbitofrontal cortexPET
주제분류정신과학

초록

Abstract

Objectives: Empathy has been conceptualized as the ability of emotional resonance and perspective-taking. Emotional awareness has been proposed as the basis of empathy. In this study we examined the relationship between empathy and mood awareness and their neural correlates in resting-state activity in normal controls and patients with schizophrenia.Methods: Empathy and mood awareness scale scores were compared between 29 patients with schizophrenia and 21 normal controls by voxel-based t-tests and voxel-based correlation analyses of resting-state 18F-FDG PET images.Results: Empathy and mood labeling scale scores were significantly decreased in schizophrenic patients. Mood monitoring positively correlated with empathy score in normal controls, but not in schizophrenic patients. In normal controls, empathy positively correlated with resting-state activities in the intraparietal sulcus and mood monitoring positively correlated with the temporal pole, frontopolar cortex, inferior temporal gyrus, entorhinal cortex and the subgenual prefrontal cortex resting activities. The orbitofrontal cortex resting activity positively correlated with mood monitoring-related subgenual prefrontal cortex activity in the normal controls. Patients with schizophrenia showed decreased orbitofrontal resting activity and loss of its correlations with mood monitoring-related regional activities.Conclusion: This study showed that alteration in the resting-state activity in schizophrenia may reflect dysfunctional empathy and distorted characteristic of emotional awareness. However, the resting-state activity may not reflect the relationship between emotional awareness and empathy.

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