생체분자와 필드의 동시국소화를 통한 플라스몬 센서의 감도향상 연구
Enhanced Detection Sensitivity of Surface Plasmon Resonance Biosensing Based on Colocalized Target Molecules and Evanescent Fields
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초록
본 논문에서는 국소화된 플라스몬 필드 내에 분자를 동시국소화 시키는 방법으로 플라스몬 센서의 감도를 향상시키기 위한 이론적 연구를 수행하였다. 플라스몬 필드의 국소화는 나노격자를 통하여 이루어 졌으며, 측정하고자 하는 분자 반응은 유전체 박막의 기울임 증착을 통하여 국소화되는 것으로 가정하였다. 근접장 기반의 필드와 분자 분포 간의 중복적분 값을 통하여 중복도가 플라스몬 센서의 감도와 밀접한 관련이 있는 것을 확인하였으며, 계산된 플라스몬 센서 특성에 근거하여 동시국소화된 플라스몬 센서의 경우, 동시국소화되지 않은 경우에 비하여, 10배 정도의 감도개선 효과가 있는 것을 확인하였다.
Abstract
We have conducted a theoretical study to improve the detection limit of a surface plasmon resonance (SPR) sensor by co-localizing plasmonic fields and target molecules of interest. The fields were localized by nanograting antennas, while target molecules that participate in a molecular interaction were assumed to be co-localized by angled evaporation of a dielectric mask layer on the nanograting antennas. We have performed the evaluation using an overlap integral between distributions of plasmon fields and molecules and confirmed the correlation of the overlap with the sensitivity of an SPR sensor. Based on the calculated sensor characteristics, it was found that the sensitivity, if the fields and molecules are co-localized, can be as much as ten times that of non-colocalized structure.
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