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우울증모델 흰쥐에 대한 죽여와 St. john's Wort의 항우울효과에 대한 비교 연구

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참고문헌

주제분류한의학

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Abstract

Objective : This study was designed to assess the protective effects of Bambusae caulis and St. John's Wort on the animal model of depression, induced by chronic mild stress(CMS)Method : Male Wistar rats were used for this experiment. The subjects were divided into 4 groups ( 1. CMS-drugs: Bambusae caulis administered during CMS treatment, 2. CMS-drugs: St. John's Wort administered during CMS treatment, 3. CMS-vehicle: Water administered during CMS treatment, 4. normal control group without CMS treatment ). After 3 weeks of CMS treatment, they were executed open field test and weight, sucrose intake were measured.Result : 1. CMS Bambusae caulis group showed significant difference of locomotor activities and marginal difference of start latency in comparison with other groups in open field test.2. There was no change of weights between CMS Bambusae caulis, St. John's Wort groups and CMS control group.3. CMS St. John's Wort group showed upper level of sucrose intake than CMS Bambusae caulis group and CMS control group.Conclusion : These results suggest that Bambusae caulis may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated locomotor activities in open field test.

참고문헌 (76)

  1. "神經精神科學", pp.378~388 (1998), 하나의학사
  2. "鬱證의 病因ㆍ病證分類에 關한 文獻的 考察", pp.219~227 (1987)
  3. "憂鬱症의 韓方的 理解에 관한 文獻考察", 12(2), pp.1~15 (2001)
  4. "Intracranial self-stimulation and sucrose intake differ as hedonic measures following chronic mild stress : interstra in and interindividual differences, Behav", 107(1-2), pp.21~33 (2000)
  5. "Depression : a new animal model sensitive to antidepressant treatment", pp.730~732 (1977), Nature
  6. "Dose-dependent decrements in adult male rat sexual behavior after neonatal clorimipramine treatment", 54(3), pp.605~609 (1996)
  7. "The validity of animal model of depression", pp.1~16 (1984)
  8. "Reduction of sucrose preference by chronic unpredictable mild stress and its restoration by a tricyclic antidepressants", pp.358~364 (1987)
  9. "Elucidation of the neurobiology of depression : insights from a novel genetic animal model", 62(4), pp.353~378 (2000)
  10. "憂鬱症誘發 흰쥐에 대한 補血安神湯의 抗憂鬱效果" (2001), 慶熙大學校 大學院
  11. "分心氣飮의 憂鬱症 모델 흰쥐에 對한 實驗的 硏究" (2000), 慶熙大學校 大學院
  12. "Chronic Mild Stress로 유발된 憂鬱症 모델 흰쥐에 대한 分心氣飮의 實驗的 硏究" (2000), 慶熙大學校 大學院
  13. "憂鬱症誘發 흰쥐에 대한 歸脾湯의 抗憂鬱效果" (2002), 慶熙大學校 大學院
  14. "Chronic Mild Stress로 誘發된 憂鬱症 모델 흰쥐에 대한 歸脾湯의 實驗的 硏究" (2001), 慶熙大學校 大學院
  15. "歸脾溫膽湯의 Chronic Mild Stress로 유발된 憂鬱症 모델 흰쥐에 대한 실험적 연구" (2000), 慶熙大學校 大學院
  16. "憂鬱症 모델 흰쥐에 대한 歸脾溫膽湯의 實驗的 硏究" (2000), 慶熙大學校 大學院
  17. "Chronic Mild Stress로 유발된 憂鬱症 모델 흰쥐에 대한 補血安神湯의 實驗的 硏究" (2001), 慶熙大學校 大學院
  18. "遠志石菖蒲散이 Chronic Mild Stress 처치 흰쥐의 憂鬱과 學習障碍에 미치는 영향" (2001), 慶熙大學校 大學院
  19. "遠志石菖蒲散이 CMS를 받은 흰쥐의 憂鬱 그리고 뇌의 TH 및 c-Fos 발현에 미치는 影響" (2002), 慶熙大學校 大學院
  20. "黃連解毒湯이 우울증 모형 동물의 우울성향 및 PVN의 c-Fos 발현에 미치는효과" (2003), 慶熙大學校 大學院
  21. "黃連解毒湯이 憂鬱症 模型動物의 水中迷路學習과 腦의 Tyrosine Hydroxylase 發顯 水準에 미치는 效果" (2003), 慶熙大學校 大學院
  22. "憂鬱症 모델 흰쥐의 水中迷路學習과 VTA의 TH 水準에 對한 古庵心腎丸去朱砂方의 效果" (2002), 慶熙大學校 大學院
  23. "淸火補心湯이 憂鬱症 模型動物의 絶望行動 不安 및 腦의 TH 와 c-Fos 發顯에 미치는 效果" (2003), 慶熙大學校 大學院
  24. "許浚 對譯 東醫寶鑑", pp.186~, 法仁文化社
  25. "竹茹의 藥理活性 및 成分硏究" (1998), 慶熙大學校 大學院
  26. "竹茹의 化學的 特性과 抗微生物 活性" (1995), 전남대학교 대학원
  27. "한방약물로부터 항고지혈증 치료약물개발 (Ⅰ) - 수종 한약재의 항고지혈증 활성검색", 30(4), pp.368~376 (1999)
  28. "Neuropharmacology of St. John's Wort(Hypericum)", 32, pp.1201~1206 (1998)
  29. "St. John's Wort for depression : A systematic review", 160, pp.152~156 (2000)
  30. "St. John's Wort : A potential therapy for elderly depressed patients?", 6(3), pp.189~196 (2000)
  31. "Efficacy of an Hypericum perforatum (St. John's Wort) extract in preventing and reverting a condition of escape deficit in rat", 21(2), pp.247~257 (1999)
  32. "校勘直譯 黃帝內經靈樞", pp.99~100 (1995)
  33. "丹溪心法附餘", pp.515~527 (1982)
  34. "臨証指南醫案", pp.463~473 (1998), 정담
  35. "實用中醫精神病學", pp.72~89 (2000), 人民衛生出版社
  36. "鬱證과 憂鬱症의 比較考察", 6(1), pp.505~514 (1997)
  37. "古庵心腎丸去朱砂方이 憂鬱症 模型 흰쥐의 憂鬱 性向 및 PVN의 c-Fos 發顯에 미치는 效果" (2002), 慶熙大學校 大學院
  38. "오수유 분획물의 항우울증 효과에 대한 연구", 13(1), pp.139~145 (1998)
  39. "人蔘과 香附子의 抗憂鬱效果에 관한 실험적 연구" (2003), 東新大學校 大學院
  40. "酸棗仁 추출물의 항스트레스 효과" (2003), 東新大學校 大學院
  41. "中國本草圖錄", pp.180~ (1990), 人民衛生出版社
  42. "生藥과 韓醫藥報社78", pp.39~42 (1978)
  43. "漢方醫藥大事典", pp.226~227 (1982)
  44. "국역본초문답", pp.218~219 (2003), 반룡
  45. "再編景岳全書", pp.407~ (1999), 大星醫學社
  46. "대나무 줄기와 잎 추출물의 化學成分 및 機能性" (2001), 慶尙大學校 大學院
  47. "대나무 수액의 화학성분 및 항미생물 활성" (2001), 全南大學校 大學院
  48. "竹茹와 覆盆子가 實驗的 糖尿에 미치는 영향", 14(1), pp.79~99 (1999)
  49. "Comparison of St. John's Wort and imipramine for treating depression : randomised controlled trial", 321(7260), pp.536~539 (2000)
  50. "Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression", 294(1), pp.88~95 (2000)
  51. "Autoradiographic quantification of neurochemical markers of serotonin dopamine and opioid systems in rat brain mesolimbic regions following chronic St. John's Wort treatment", 367, pp.126~133 (2003)
  52. "Monoamine oxidase inhibitory activity of some Hypericum species native to South Brazil", 53, pp.1273~1279 (2001)
  53. "Effects of Hypericum perforatum on levels of 5-Hydoroxy tryptamine Noradrenaline and Dopamine in the cortex diencephalon and brainstem of the rat", 51, pp.723~728 (1999)
  54. "Effect of the Hypericum Perforatum extract on serotonin turnover in the mouse brain", 33, pp.60~65 (2000)
  55. "Hyperforin enhances the extracellular concentrations of catecholamines serotonin and glutamate in the rat locus coeruleus", 262, pp.199~202 (1999)
  56. "Neuroendocrine evidence for dopaminergic actions of hypericum extract(LI 160) in healthy volunteers", 46, pp.581~584 (1999)
  57. "Evidence that total extract of Hypericum perforatum affects exploratory behavior and experts anxiolytic effects in rat", 65(4), pp.627~633 (2000)
  58. "Attention of alcohol intake by extract of Hypericum perforatum in two different strains of alcohol-preferring rats", 34(5), pp.699~705 (1999)
  59. "우울증 환자에서 Hypericum perforatum(St. John's Wort) 에 의해 유발된 조증 1례", 12(2), pp.151~156 (2001)
  60. "제3개정판 최신정신의학", pp.199~219 (1996), 일조각
  61. "우울증에 대한 동물 모형으로서 CMS 처치가 흰쥐의 수동회피학습에 미치는 효과", 6(3), pp.537~556 (1999)
  62. "Chronic desipramine alter stress-induced behaviors and regional expression of the immediate early gene,c-Fos", 51(2-3), pp.331~338 (1995)
  63. "Stress-induced c-Fos expression in the rat locus coeruleus is dependent on neurokinin 1 receptor activation", 94(4), pp.1183~1188 (1999)
  64. "Animal models of depression : utility for transgenic research", 11(1), pp.53~58 (2000)
  65. "Increased expression of magnocellular arginine vasopressin mRNA in paraventricular nucleus of stress-induced depression-model rats", 63(1), pp.23~31 (1998)
  66. "Effect of chronic mild stress on performance in behavioural tests relevant to anxiety and depression", 56, pp.861~867 (1994)
  67. "Reveral of stress induced anhedonia by the atypical antidepressants", pp.433~438 (1992)
  68. "Fluoxetine과 Choline 병합 투여가 경도의 만성적 스트레스 처리한 백서의 수동적 회피학습에 미치는 영향", 37(2), pp.372~380 (1998)
  69. "스트레스 우울증 동물모델에서 paroxetine의 항우울효과와 기억증진효과", 5(1), pp.55~64 (1997)
  70. "Influence of S-adenosyl-L-methionine on chronic mild stress-induced anhedonia in castrated rats", 127(3), pp.645~654 (1999)
  71. "Acute and chronic stress effects on open field activity in the rat : implications for a model of depression", 5(2), pp.247~251 (1981)
  72. "Kindling-induced emotional behavior in male and female rats", 117(3), pp.632~640 (2003)
  73. "Chlordiazepoxide-modified exploration in rats", pp.462~469 (1972)
  74. "Extinction of fearⅡ Effect of chlordiazepoxide and chlorpromazine on fear and exploratory behavior in rats", pp.297~312 (1971)
  75. "Gender-specific effects of social housing in rats after chronic mild stress exposure", 27(1), pp.21~30 (2003)
  76. "Validity, reliability and utility of the chronic mild stress model of depression : a 10-year reviewand evaluation", 134(4), pp.319~329 (1997)

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