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鎭肝熄風湯加減方이 中樞神經系에 미치는 효능에 관한 硏究

Effects of Jingansikpungtanggagam-bang on Central Nerve System

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참고문헌

주제분류한의학

초록

Abstract

objective : This study was designed to assess Effects of Jingansikpungtanggagam-bang on Central Nerve System. Method : Jingansikpungtanggagam-bang, a Korean traditional prescription, was evaluated for its anticonvulsant effect, hypnotic activity, analgesic action, anxiolytic effect, memory enhancement, and MAO inhibitory activity and determined the content of neurotransmitter in brain by HPLC method. Result : 1. The extract increased potently anticonvulsant effect at 1g/kg by 5.6-fold extention of onset time against control group. 2. The extract increased hypnosis at 500mg/kg by over twofold length of sleeping time compared to control.3. The extract showed a significant analgesic effect with 86.0% inhibition on writhing frequency at 500mg/kg by phenylquinone-induced writhing test.4. The extract inhibited dose-dependently the activity of monoamine oxidase in vitro. 5. This prescription increased the brain levels of serotonin and 5-hydroxyindoleacetic acid by 3.3% and 1.4%, respectively. 6. the extract exhibited the anxiolytic effect with 21.3% decrease of the immobility duration against control group.7. the extract enhanced memory recovery on scopolamine-induced impairment of passive avoidance performance at 1g/kg pretreatment with 20.2% increase of latency time. Conclusion : The result sugguest that Jingansikpungtanggagam-bang can be used effectively as a sedative prescription in Korean traditional medicine.

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