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定癎湯의 抗痙攣 效果 및 작용기전에 관한 硏究

Anticonvulsant Effects of JeongGan-Tang and Its Putative Action Mechanism

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Abstract

Objective : This study was performed to examine the anticonvulsant effects of the extracts of JeongGan-Tang and explanation of its action mechanism. Method :1) The inhibitory effect on convulsions induced by pentylenetetrazole, picrotoxin and strychnine was investigated in vivo2) The inhibitory effect on GABA transaminase activity was evaluated in vivo and in vitro.3) The brain GABA level and glutamate level in pentylenetetrazole-induced convulsion model were analyzed by HPLC,

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