天王補心丹 熱水抽出物, 超微細粉末劑形이 Alzheimer's Disease 病態 모델에 미치는 影響
The Effects of ChenwhangBosindan(CBD) Hot Water Extract & Ultra-fine Powder on the Alzheimer's Disease Model
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초록
Objective : This experiment was designed to investigate the effect of the CBD hot water extract & ultra-fine Powder on Alzheimer's Disease Model Induced by βA. Method : The effects of the CBD hot water extract on expression of interleukin-1 beta(IL-1β), TNF-α mRNA and production of IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide(LPS). The effects of the CBD hot water extract & ultra-fine powder on (1) the behavior (2) expression of IL-1β, tumor necrosis factor-alpha(TNF-α), (3) the infarction area of the hippocampus in Alzheimer's diseased mice induced with βA were investigated. Result : The CBD hot water extract suppressed the expression of IL-1β, TNF-α mRNA in BV2 microglia cell line treated with LPS. The CBD hot water extract significantly suppressed the production of IL-1β, TNF-α in BV2 microglial cell line treated with LPS. The CBD hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured step-through latency and distance movement-through latency. The CBD hot water extract & ultra-fine powder significantly suppressed the expression of IL-1β and TNF-α protein in the microglial cell of mice with Alzheimer's disease induced by βA. The CBD hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer's disease induced by βA. The CBD hot water extract & ultra-fine powder reduced infarction area of hippocampus, in the mice with Alzheimer's disease induced by βA. Conclusions : These results suggest that the CBD hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the CBD hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.
Abstract
Objective : This experiment was designed to investigate the effect of the CBD hot water extract & ultra-fine Powder on Alzheimer's Disease Model Induced by βA. Method : The effects of the CBD hot water extract on expression of interleukin-1 beta(IL-1β), TNF-α mRNA and production of IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide(LPS). The effects of the CBD hot water extract & ultra-fine powder on (1) the behavior (2) expression of IL-1β, tumor necrosis factor-alpha(TNF-α), (3) the infarction area of the hippocampus in Alzheimer's diseased mice induced with βA were investigated. Result : The CBD hot water extract suppressed the expression of IL-1β, TNF-α mRNA in BV2 microglia cell line treated with LPS. The CBD hot water extract significantly suppressed the production of IL-1β, TNF-α in BV2 microglial cell line treated with LPS. The CBD hot water extract & ultra-fine powder a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by βA in the Morris water maze experiment, which measured step-through latency and distance movement-through latency. The CBD hot water extract & ultra-fine powder significantly suppressed the expression of IL-1β and TNF-α protein in the microglial cell of mice with Alzheimer's disease induced by βA. The CBD hot water extract & ultra-fine powder suppressed the over-expression of AChE activity in the serum of the mice with Alzheimer's disease induced by βA. The CBD hot water extract & ultra-fine powder reduced infarction area of hippocampus, in the mice with Alzheimer's disease induced by βA. Conclusions : These results suggest that the CBD hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease. Investigation into the clinical use of the CBD hot water extract & ultra-fine powder for Alzheimer's disease is suggested for future research.
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