βA로 유도된 Alzheimer’s Disease 동물모델에 대한 荊防瀉白散의 효과
The Effects of HyungBangSaBaek-San(JingFangXieBaiSan) on the Alzheimer's Disease Model Induced by βA
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Objectives :This research investigates the effect of the HBSBS on Alzheimer's disease. Specifically, the effects of the HBSBS extract on (1) the behavior (2) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's disease mice induced with βA were investigated. Methods :The effects of the HBSBS extract suppressed the expression of IL-1β, IL-6, TNF-α and NOS-II mRNA in BV2 microglial cell line treated with LPS plus βA were investigated. The effects of the HBSBS extract on the behavior of the memory deficit mice induced by scopolamine were investigated. Results :1. The HBSBS extract suppressed the expression of IL-1β, IL-6, TNF-α and NOS-II mRNA in BV2 microglial cell line treated with LPS plus βA. 2. The HBSBS extract suppressed the expression of βA protein production in BV2 microglial cell line treated with LPS plus βA. 3. The HBSBS extract showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. 4. The HBSBS group suppressed the over-expression of IL-1β protein, TNF-α protein significantly in the mice with Alzheimer's disease induced by βA. 5. The HBSBS group reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by βA. 6. The HBSBS group reduced tau protein, and GFAP in the brain tissue of the mice with AD induced by βA. Conclusions :These results suggest that the HBSBS group may be effective for the treatment of AD. Thus, HBSBS could be considered among the future therapeutic drugs indicated for the treatment of AD.
Abstract
Objectives :This research investigates the effect of the HBSBS on Alzheimer's disease. Specifically, the effects of the HBSBS extract on (1) the behavior (2) the infarction area of the hippocampus, and brain tissue injury in Alzheimer's disease mice induced with βA were investigated. Methods :The effects of the HBSBS extract suppressed the expression of IL-1β, IL-6, TNF-α and NOS-II mRNA in BV2 microglial cell line treated with LPS plus βA were investigated. The effects of the HBSBS extract on the behavior of the memory deficit mice induced by scopolamine were investigated. Results :1. The HBSBS extract suppressed the expression of IL-1β, IL-6, TNF-α and NOS-II mRNA in BV2 microglial cell line treated with LPS plus βA. 2. The HBSBS extract suppressed the expression of βA protein production in BV2 microglial cell line treated with LPS plus βA. 3. The HBSBS extract showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze. 4. The HBSBS group suppressed the over-expression of IL-1β protein, TNF-α protein significantly in the mice with Alzheimer's disease induced by βA. 5. The HBSBS group reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by βA. 6. The HBSBS group reduced tau protein, and GFAP in the brain tissue of the mice with AD induced by βA. Conclusions :These results suggest that the HBSBS group may be effective for the treatment of AD. Thus, HBSBS could be considered among the future therapeutic drugs indicated for the treatment of AD.
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