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三精丸이 高脂肪 食餌 흰 쥐의 비만에 미치는 영향

Effects of Samjung-hwan(Sānjīngwán) on Obesity and Lipid Metabolism in Rats with High Fat Diet

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Objectives : This study was performed to show the effects of Samjung-hwan (Sānjīngwán) extract on obesity and lipid metabolism of rats fed high fat diet. Methods : Crushed Samjung-hwan(Sānjīngwán) 245 g was extracted with methyl alcohol. The extract was evaporated under reduced pressure to give 21.8 g. 20 rats were divided into normal, control, and two test groups. For 6 weeks, The normal group rats were supplied with a normal diet. The control group rats were supplied with a high fat diet. The test group 1 rats were supplied with a high fat diet and Samjung-hwan(Sānjīngwán) extract 250 mg/kg and the test group 2 rats were supplied witha high fat diet and Samjunghwan(Sānjīngwán) extract 500 mg/kg. Results : 1) The control group rats showed significantly increased weight of peritoneal fat than the nornal group rats. The test group 1 rats did not show significant difference compare to the control group rats, and the test group 2 rats showed significantly decreased weight of peritoneal fat than the control group rats. 2) The control group rats showed significantly increased triglyceride than the nornal group rats. The test group 1 rats showed significantly decreased triglyceride than the control group rats, and the test group 2 rats showed significantly decreased triglyceride than the control group rats. 3) The control group rats showed significantly increased LDL-cholesterol than the nornal group rats. The test group 1 rats showed significantly decreased LDL-cholesterol than the control group rats, and the test group 2 rats did not show significant difference compare to the control group rats. Conclusions: These results suggest that effectiveness of Samjung-hwan(Sānjīngwán) extract to control the obesity and abnormal lipid metabolism caused by a high fat diet.

Abstract

Objectives : This study was performed to show the effects of Samjung-hwan (Sānjīngwán) extract on obesity and lipid metabolism of rats fed high fat diet. Methods : Crushed Samjung-hwan(Sānjīngwán) 245 g was extracted with methyl alcohol. The extract was evaporated under reduced pressure to give 21.8 g. 20 rats were divided into normal, control, and two test groups. For 6 weeks, The normal group rats were supplied with a normal diet. The control group rats were supplied with a high fat diet. The test group 1 rats were supplied with a high fat diet and Samjung-hwan(Sānjīngwán) extract 250 mg/kg and the test group 2 rats were supplied witha high fat diet and Samjunghwan(Sānjīngwán) extract 500 mg/kg. Results : 1) The control group rats showed significantly increased weight of peritoneal fat than the nornal group rats. The test group 1 rats did not show significant difference compare to the control group rats, and the test group 2 rats showed significantly decreased weight of peritoneal fat than the control group rats. 2) The control group rats showed significantly increased triglyceride than the nornal group rats. The test group 1 rats showed significantly decreased triglyceride than the control group rats, and the test group 2 rats showed significantly decreased triglyceride than the control group rats. 3) The control group rats showed significantly increased LDL-cholesterol than the nornal group rats. The test group 1 rats showed significantly decreased LDL-cholesterol than the control group rats, and the test group 2 rats did not show significant difference compare to the control group rats. Conclusions: These results suggest that effectiveness of Samjung-hwan(Sānjīngwán) extract to control the obesity and abnormal lipid metabolism caused by a high fat diet.

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