기억력 감퇴 모델에서 靈神草, 遠志, 石菖蒲 혼합제제의 기억력 및 인지 기능 개선에 관한 연구
Nootropic and Anti-amnestic Effect of PPA on scopolamine-induced Cognitive Impairment in Mice
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In the present study, we assessed the effect of the PPA (Polygala japonica Houtt., Polygala tenuifolia WILLD. and Acorus gramineus SOLAND. mixed preparation), a traditional herbal prescription, on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of PPA was investigated using a passive avoidance test, Y-maze test and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). A single PPA (400 and 800 (mg/kg)) administration significantly reversed the scopolamine-induced cognitive impairments in the passive avoidance test (P <0.05). On the Y-maze test, PPA (400 and 800 (mg/kg)) also significantly reversed scopolamine- induced cognitive impairments in mice (P <0.05). PPA also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P <0.05). These results suggest that PPA attenuates amnesic state induced by scopolamine and that these Effect are mediated by enhancing the cholinergic dysfunction.
Abstract
In the present study, we assessed the effect of the PPA (Polygala japonica Houtt., Polygala tenuifolia WILLD. and Acorus gramineus SOLAND. mixed preparation), a traditional herbal prescription, on the learning and memory impairments induced by scopolamine. The cognition-enhancing effect of PPA was investigated using a passive avoidance test, Y-maze test and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). A single PPA (400 and 800 (mg/kg)) administration significantly reversed the scopolamine-induced cognitive impairments in the passive avoidance test (P <0.05). On the Y-maze test, PPA (400 and 800 (mg/kg)) also significantly reversed scopolamine- induced cognitive impairments in mice (P <0.05). PPA also improved escape latencies in training trials and increased swimming times and distances within the target zone of the Morris water maze (P <0.05). These results suggest that PPA attenuates amnesic state induced by scopolamine and that these Effect are mediated by enhancing the cholinergic dysfunction.
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