Behavioral and Psychological Symptoms of Dementia Treated with Korean Medicine: A Case Report
1
조회
0
다운로드
1
인용
0
참고문헌
키워드
초록
Objectives: To determine the effects of Korean medicine on behavioral and psychological symptoms of dementia (BPSD) of an Alzheimer's disease (AD) patient.Methods: A 85-year old female patient diagnosed with AD was treated with herbal medicine formula Chungsimyeonja-tang (淸心蓮子湯), Woohwangchungsim-won (牛黃淸心元), and acupuncture. Korean version of Mini-mental State Examination (MMSE-K) scores were used at baseline and post treatment as outcome measures to evaluate clinical symptoms of the patient.Results: Improvements in MMSE-K post treatment scores were observed compare to those at baseline. BPSD were also alleviated. Such changes were visually noticeable.Conclusions: Herbal medicine and acupuncture treatment were effective in alleviating symptoms of AD. Further studies with a larger sample size and randomized clinical trials are needed to obtain more reliable and valid treatment outcomes.
Abstract
Objectives: To determine the effects of Korean medicine on behavioral and psychological symptoms of dementia (BPSD) of an Alzheimer's disease (AD) patient.Methods: A 85-year old female patient diagnosed with AD was treated with herbal medicine formula Chungsimyeonja-tang (淸心蓮子湯), Woohwangchungsim-won (牛黃淸心元), and acupuncture. Korean version of Mini-mental State Examination (MMSE-K) scores were used at baseline and post treatment as outcome measures to evaluate clinical symptoms of the patient.Results: Improvements in MMSE-K post treatment scores were observed compare to those at baseline. BPSD were also alleviated. Such changes were visually noticeable.Conclusions: Herbal medicine and acupuncture treatment were effective in alleviating symptoms of AD. Further studies with a larger sample size and randomized clinical trials are needed to obtain more reliable and valid treatment outcomes.
참고문헌 (17)
- American Psychiatric Association, "Diagnostic and Statistical Manual of Mental Disorders" (2013), American Psychiatric Association
- Brookmeyer R, "National estimates of the prevalence of Alzheimer’s disease in the United States", Alzheimer's & Dementia, 7(1), pp.61~73 (2011)
- "Amnesic disorders", Lancet, 380(9851), pp.1429~1440 (2012)
- Alzheimer’s Association, "2017 Alzheimer's disease facts and figures", Alzheimer's & Dementia, 13(4), pp.325~373 (2017)
- Yan H, "Treating senile dementia with traditional Chinese medicine", Clinical interventions in aging, 2(2), pp.201~ (2007)
- Na DR, "Clinical Appraoch of Dementia", Journal of Korean Medical Association, 45(4), pp.361~367 (2002)
- Wang J, "Disrupted functional brain connectome in individuals at risk for Alzheimer's disease", Biological psychiatry, 73(5), pp.472~481 (2013)
- Cummings JL, "Alzheimer Disease", JAMA, 287(18), pp.2335~2338 (2002)
- Ho YS, "Drug discovery from Chinese medicine against neurodegeneration in Alzheimer's and vascular dementia", Chinese medicine, 6(1), pp.15~ (2011)
- 임수혜, "Pharmacognostic outlooks on medical herbs of Sasang typology", Integrative Medicine Research, 6(3), pp.231~239 (2017), 한국한의학연구원[DOI]
- Kim JY, "Recent progress and prospects in Sasang constitutional medicine: A traditional type of physiome-based treatment", Progress in biophysics and molecular biology, 116(1), pp.76~80 (2014)
- Jeong HJ, "Chungsim-Yeunja-Tang decreases the inflammatory response in peripheral blood mononuclear cells from patients with cerebral infarction through an NF-κB dependent mechanism", Journal of neuroinflammation, 7(1), pp.85~ (2010)
- Jung WS, "Uhwang Chungsim Won decreases blood oxygen level-dependent fMRI signal response to a motor stimulation task", Chinese journal of integrative medicine, 21(7), pp.493~499 (2015)
- 이동영, "Mini-Mental State Examination의 한국 노인 정상규준 연구", 신경정신의학, 41(3) (2002), 대한신경정신의학회
- 최성혜, "한국판 Global Deterioration Scale의 타당도", 대한신경과학회지, 20(6), pp.612~617 (2002), 대한신경과학회
- Choi SH, "Estimating the validity of the Korean version of expanded clinical dementia rating (CDR) scale", Journal of the Korean Neurological Association, 19(6), pp.585~591 (2001)
- Lawlor BA, "Behavioral and psychological symptoms in dementia: the role of atypical antipsychotics", Journal of Clinical Psychiatry, 65(11), pp.5~10 (2004)