우리나라 쌍둥이 발생 분포에 관한 연구, 1991-2018
Trends of Twin Birth in Korea, 1991-2018
2
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
Objectives: To determine the trend of monozygotic (MZ) and dizygotic (DZ) twinning in Korea from 1991 to 2018. Methods: This study used twin birth certificate data (1991-1994 years: 13,527 pairs, 2000-2018 years: 115,656 pairs), provided by Statistics Korea. Weinberg’s differential rule was used to estimate the number of MZ and DZ twin births. The impact of assisted reproductive technologies (ART) on MZ and DZ twinning was analyzed by examining data after the introduction of the national support program for infertile couples. The odds ratio (OR) and 95% confidence intervals were calculated to describe the trend in the MZ and DZ twinning ratio. Results: From 1991 to 2018, the DZ/MZ ratio increased significantly from 0.45 to 3.30. Prior to the introduction of the national support program for infertile couples (1991-1994 years), the DZ/MZ ratio was 0.54, but after its introduction, the DZ/MZ ratio was 1.99 in 2005-2009 (OR: 3.69, 95% confidence interval: 3.53-3.85), 2.53 in 2010-2014 (14.69, 4.49-4.89), and 3.02 in 2015-2017 (5.61, 5.37-5.87). Conclusions: Over the past three decades, twin birth and proportion of DZ twining have risen in Korea, due to the widespread use of ART. There is a need to understand the factors contributing to DZ to MZ twining birth whether twining birth originated spontaneously or from assisted-conception.
Abstract
Objectives: To determine the trend of monozygotic (MZ) and dizygotic (DZ) twinning in Korea from 1991 to 2018. Methods: This study used twin birth certificate data (1991-1994 years: 13,527 pairs, 2000-2018 years: 115,656 pairs), provided by Statistics Korea. Weinberg’s differential rule was used to estimate the number of MZ and DZ twin births. The impact of assisted reproductive technologies (ART) on MZ and DZ twinning was analyzed by examining data after the introduction of the national support program for infertile couples. The odds ratio (OR) and 95% confidence intervals were calculated to describe the trend in the MZ and DZ twinning ratio. Results: From 1991 to 2018, the DZ/MZ ratio increased significantly from 0.45 to 3.30. Prior to the introduction of the national support program for infertile couples (1991-1994 years), the DZ/MZ ratio was 0.54, but after its introduction, the DZ/MZ ratio was 1.99 in 2005-2009 (OR: 3.69, 95% confidence interval: 3.53-3.85), 2.53 in 2010-2014 (14.69, 4.49-4.89), and 3.02 in 2015-2017 (5.61, 5.37-5.87). Conclusions: Over the past three decades, twin birth and proportion of DZ twining have risen in Korea, due to the widespread use of ART. There is a need to understand the factors contributing to DZ to MZ twining birth whether twining birth originated spontaneously or from assisted-conception.
참고문헌 (26)
- S.R. Murray, "Multiple pregnancies following assisted reproductive technologies – A happy consequence or double trouble?", Seminars in Fetal and Neonatal Medicine, 19(4), pp.222~227 (2014), Elsevier BV[DOI]
- Hyun Sun Ko, "Multiple birth rates of Korea and fetal", neonatal, PLOS ONE, pp.2018, 13(8)[DOI]
- AGATA V. D'ADDATO, "SECULAR TRENDS IN TWINNING RATES", Journal of Biosocial Science, 39(1), pp.147~151 (2007), Cambridge University Press (CUP)[DOI]
- Martin JA, "Births: final data for 2005. National Vital Statistics Reports;56:1-103. Hyattsville", Natl Vital Stat Rep, 56(6), pp.1~103 (2007)
- 박상화, "우리나라 다태아 출생률 추이에 관한 연구: 1981–2017", 한국모자보건학회지, 23(3), pp.202~208 (2019), 한국모자보건학회[DOI]
- Anne Tandberg, "Increasing twinning rates in Norway, 1967–2004: the influence of maternal age and assisted reproductive technology (ART)", Acta Obstetricia et Gynecologica Scandinavica, 86(7), pp.833~839 (2007), Wiley[DOI]
- William H. James, "Second survey Of secular trends in twinning rates", Journal of Biosocial Science, 14(4), pp.481~497 (1982), Cambridge University Press (CUP)[DOI]
- Derom C, "Iatrogenic multiple pregnancies in East Flanders, Belgium", Fertil Steril, 60(3), pp.493~496 (1993)
- Edward E. Wallach, "Multiple Pregnancies Following Induction of Ovulation", Fertility and Sterility, 35(2), pp.105~123 (1981), Elsevier BV[DOI]
- Stephen Tong, "Use of dizygotic to monozygotic twinning ratio as a measure of fertility", The Lancet, 349(9055), pp.843~845 (1997), Elsevier BV[DOI]
- Y. IMAIZUMI, "A COMPARATIVE STUDY OF ZYGOTIC TWINNING AND TRIPLET RATES IN EIGHT COUNTRIES, 1972–1999", Journal of Biosocial Science, 35(2), pp.287~302 (2003), Cambridge University Press (CUP)[DOI]
- Bulmer MG, "The biology of twining in man" (1970), Clarendon Press
- Yoon-Mi Hur, "Changes in Twinning Rates in South Korea: 1981–2002", Twin Research and Human Genetics, 8(1), pp.76~79 (2005), Cambridge University Press (CUP)[DOI]
- Park SH, "Secular trends of monozygotic and dizygotic twinning rates in Korea, 1991-2006", J Reprod Med Popul, 21, pp.111~116 (2008)
- Korea Ministry of Health and Welfare, "National supporting program for infertile couples. Guideline for 2016 maternal and childe health services", Korea Ministry of Health and Welfare, 135~161 (2016)
- "Korean Statistical Information Service"[URL]
- M.G. Bulmer, "Is Weinberg's Method Valid?", Acta geneticae medicae et gemellologiae, 25(1), pp.25~28 (1976), Cambridge University Press (CUP)[DOI]
- Johan Fellman, "Weinberg's Differential Rule Reconsidered", Human Biology, 78(3), pp.253~275 (2006), Project Muse[DOI]
- Lambert RD, "Safety issues in assisted reproduction technology: the children of assisted reproduction confront the responsible conduct of assisted reproductive technologies", Hum Reprod, 17(12), pp.3011~3015 (2002)[DOI]
- Pinborg A, "IVF", ICSI twin pregnancies : risks and prevention, 2005, pp.11(6), 575~593
- Wright VC, "Assisted reproductive technology surveillance-United States, 2002", MMWR Morb Mortal Wkly Rep, 54(2), pp.1~24 (2005)
- Zhu JL, "Infertility, infertility treatment and twinning : the Danish National Birth Cohort", Hum Reprod, 22(4), pp.1086~1090 (2007)[DOI]
- Y. Imaizumi, "The Twinning Rates by Zygosity in Japan, 1975-1994", Acta geneticae medicae et gemellologiae: twin research, 46(1), pp.9~22 (1997), Cambridge University Press (CUP)[DOI]
- Kanazawa S, "Why are there more same-sex than opposite-sex dizygotic twins?", Hum Reprod, 33(5), pp.930~934 (2018)[DOI]
- Sally Ann Rhea, "Higher Rates of DZ Twinning in a Twenty-First Century Birth Cohort", Behavior Genetics, 47(5), pp.581~584 (2017), Springer Science and Business Media LLC[DOI]
- Chia KS, "Twin births in Singapore : a population-based study using the national birth registry", Ann Acad Med Singapore, 33(2), pp.195~199 (2004)