폐경 여성에서 출산 횟수와 당뇨병의 관련성과 모유수유 기간과의 상호작용
Relationship between Parity and Diabetes Mellitus and Interaction with Breastfeeding Period among Postmenopausal Women
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Objectives: This study aimed to determine the relationship between parity and diabetes mellitus and to examine effect of the interaction between the breastfeeding period, parity, and diabetes mellitus in postmenopausal women. Methods: The study was conducted on 4,053 women aged ≥ 50 who had participated in the 5th Korea National Health and Nutrition Survey from 2010 to 2012. The women were divided into two groups based on the median parity, furthermore, they were divided into three groups on the breastfeedng period. Diabetes mellitus was defined based on the fasting blood glucose levels (blood glucose level ≥ 126 mg/dL) and/or use of an anti-hypoglycemic agent or administration of insulin. A logistic regression analysis was conducted to assess the association between parity and diabetes mellitus. The sociodemographic factors and health indicators, along with factors related to women’s reproduction were adjusted to the model as confounding variables. Results: The relationship between parity and diabetes mellitus was statistically significant without adjusting for confounding variables (odds ratio, OR = 1.73, 95% confidence interval, 95% CI = 1.40-2.13, p< 0.001). However, adjusting for confounding factors revealed that the relationship was not statistically significant (OR = 1.08, 95% CI = 0.79-1.48, p= 0.633). Analysis of the interaction terms between parity and breastfeeding period revealed that the main effects of parity were statistically significant (p= 0.034); however, the main effects of the breastfeeding period were not. The interaction term of the breastfeeding period and parity was statistically significant (p= 0.042). Among women who breastfed for 0-6 months, those who had delivered 4-12 children were at a 5.56- times higher risk of diabetes mellitus than those who had delivered 1-3 children. Conclusions: The association between parity and diabetes mellitus and the interaction between breastfeeding period and parity were statistically significant. Among women with shorter breastfeeding periods, those who had delivered relatively more children were at a higher risk of diabetes mellitus than those who had delivered fewer children.
Abstract
Objectives: This study aimed to determine the relationship between parity and diabetes mellitus and to examine effect of the interaction between the breastfeeding period, parity, and diabetes mellitus in postmenopausal women. Methods: The study was conducted on 4,053 women aged ≥ 50 who had participated in the 5th Korea National Health and Nutrition Survey from 2010 to 2012. The women were divided into two groups based on the median parity, furthermore, they were divided into three groups on the breastfeedng period. Diabetes mellitus was defined based on the fasting blood glucose levels (blood glucose level ≥ 126 mg/dL) and/or use of an anti-hypoglycemic agent or administration of insulin. A logistic regression analysis was conducted to assess the association between parity and diabetes mellitus. The sociodemographic factors and health indicators, along with factors related to women’s reproduction were adjusted to the model as confounding variables. Results: The relationship between parity and diabetes mellitus was statistically significant without adjusting for confounding variables (odds ratio, OR = 1.73, 95% confidence interval, 95% CI = 1.40-2.13, p< 0.001). However, adjusting for confounding factors revealed that the relationship was not statistically significant (OR = 1.08, 95% CI = 0.79-1.48, p= 0.633). Analysis of the interaction terms between parity and breastfeeding period revealed that the main effects of parity were statistically significant (p= 0.034); however, the main effects of the breastfeeding period were not. The interaction term of the breastfeeding period and parity was statistically significant (p= 0.042). Among women who breastfed for 0-6 months, those who had delivered 4-12 children were at a 5.56- times higher risk of diabetes mellitus than those who had delivered 1-3 children. Conclusions: The association between parity and diabetes mellitus and the interaction between breastfeeding period and parity were statistically significant. Among women with shorter breastfeeding periods, those who had delivered relatively more children were at a higher risk of diabetes mellitus than those who had delivered fewer children.
참고문헌 (29)
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