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근위 대퇴골 해면골의 미세 구조의 변화

Changes in Microstructure of Proximal Femoral Trabecular Bone

김상환|박진|원예연|손광현
대한골다공증학회 (THE KOREAN SOCIETY OF OSTEOPOROSIS)|2010.08|OSTEOPOROSIS (The Journal of Korean Society of Osteoporosis)|제8권 제2호|pp. 160-170

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키워드

노화Proximal femurTrabecular bone미세 구조근위 대퇴골골소주
주제분류기타의약학

초록

목적: 연령에 따른 사람의 근위 대퇴골 골소주의 3차원적미세 구조를 부위별로 조사하는 것이다. 재료 및 방법: 남성 시신으로부터 얻은 27개 대퇴골을 6 구역으로 나누고 각각에서 원통형 시편을 구해 총 162개의 골소주를 얻었다. 미세 컴퓨터 단층 촬영기를 이용하여 영상을 얻어 해면뼈 체적비(BV/TV), 골소주 개수(Tb. N), 골소주 굵기(Tb. Th), 골소주간 거리(Tb. Sp), 구조 모델 지수(SMI), 해면뼈 이방성 정도(DOA)를 분석하였다. 결과: 근위 대퇴골의 서로 다른 부위에 따른 골소주의 미세구조의 변화는 나이에 따라 다르다. 해면뼈 체적비의 유의한 감소와 연령과 관련하여 골소주 굵기의 감소를 보였다. 부위별로 분석한 결과 전자부 상부와 하부 사이에 해면뼈 체적비, 골소주 굵기, 골소주간 거리, 골소주 개수, 구조 모델 지수, 해면뼈 이방성 정도에 유의한 차이를 보였다. 결론: 본 연구에서는 남성 근위 대퇴골의 연령과 관련된 골 소실과 골소주 미세 구조의 변화의 변화가 일정하지 않았다. 연령에 따라 근위 대퇴골의 서로 다른 부위가 골소주의 미세 구조에 있어 많은 차이가 있음을 보여주었다.

Abstract

Objectives: We hypothesize that the age-related changes in trabecular bone microstructure appear to be varied from specific anatomic sub-regions of the proximal femur followed by non-uniform bone loss. The purpose of this study was therefore to explore regional variations in the 3D microstructure of trabecular bone in human proximal femur, with respect to aging. Methods: A total of 162 trabecular bone cores from six regions of 27 femora of male cadaver donors were scanned using micro-computed tomography (micro-CT). The following microstructural parameters were calculated: bone volume fraction (BV/TV), trabecular number (Tb. N), thickness (Tb.Th) and separation (Tb.Sp), structure model index (SMI), and degree of anisotropy (DOA). Results: Age-related changes in trabecular microstructure varied from different regions of the proximal femur. There was a significant decrease in bone volume fraction and an almost identical decrease in trabecular thickness associated with aging at any region. Regional analysis demonstrated a significant difference in BV/TV, Tb.Th, Tb.Sp, Tb. N and DOA between superior and inferior neck, as well as a significant difference in BV/TV, Tb.Sp, Tb. N, SMI and DOA between superior and inferior trochanter. Conclusion: Age-related changes in bone loss and trabecular microstructure within the male proximal femur are not uniform in this cadaveric population.

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