해면뼈의 구조적 특성과 기계적 강도의 상관관계 -사람 대퇴골두 으뜸 압박 골소주-
Correlation of the Microstructural and Mechanical Strength of the Trabecular Bone -The Primary Compression Trabeculae in Human Femoral Head-
1
조회
0
다운로드
3
인용
0
참고문헌
키워드
초록
목적: 뼈 강도를 평가함에 있어서 기계적 강도는 구조적 특성과 더불어 중요한 인자이다. 많은 연구자들은 해면뼈의 구조적 특성과 기계적 강도를 분석하여 뼈 강도를 평가하고자 노력하고 있다. 본 연구에서는 해면뼈의 미세구조적 특성과 기계적 강도를 분석하여 상관관계를 평가하고자 하였다. 방법: 인공 고관절 치환술을 받은 환자 11례와 사체에서 10례, 총 21례의 으뜸 압박 골소주군에서 원통형 샘플을 제작하였다. 샘플의 크기는 직경 19 mm, 높이 15mm이었다. 모든 샘플은 미세단층촬영기에 의해서 촬영되어 미세구조적 특성이 분석되었다. 또한 유한요소해석과 만능재료시험기를 이용하여 압축실험을 수행하여 기계적 강도를 구하였다. 결과: 항복응력과 탄성계수는 유한요소해석과 만능재료시험기에서 각각 13.58 ㎫과 266.81 ㎫ 그리고 13.17 ㎫과 288.51 ㎫로 분석되었다. 결론: 기계적 강도와 구조적 특성은 유의한 상관관계를 보임으로서 뼈 강도를 예측할 때 구조적 특성과 더불어 기계적 강도를 분석한다면 보다 정확한 예측이 가능하리라 사려된다.
Abstract
Objectives: Bone mechanical strength is one of the factors to assess for bone fracture risk. Many researchers try to predict the fracture risk by using morphometry indices, experimental test(Instron) and a finite element analysis(FEA). The purpose of this study was to evaluate the correlation between the microstructural property and mechanical strength in the primary compression trabeculae in the human femoral head. Methods: Twenty-one human femoral heads were obtained from 11 patients undergoing a total hip replacement and 10 cadavers. Cylindrical trabecular bone samples were cored from the primary compressive trabecular pattern in the femoral head. The sample size has diameter of 19mm and a height of 15mm. All samples were scanned with a micro-CT at a spatial resolution of 21.31μm. Based on the serial micro-images, the structural properties were directly calculated from ANT software. The mechanical strength was calculated for the experimental test and the FEA. Results: The average yield stress and elastic modulus from the FEA and the Instron system were 13.58㎫ and 266.81㎫, 13.17㎫ and 288.51㎫, respectively. Pearson correlations between the morphometry indices, Tb.Sp, BV, BS/BV, BV/TV, MIL and Tb.N were significantly correlated with the mechanical strength. Conclusion: This result indicates that significant correlation the mechanical strength and structural properties can be a useful tool to predict the bone mechanical strength.
참고문헌 (23)
- NIH Consensus Development Panel on Osteoporosis Prevention, Diagnosis, and Therapy, "Osteoporosis Prevention, Diagnosis, and Therapy", JAMA, 285, pp.785~795 (2001)
- IH Park, "Socioeconomic cost for osteoporosisassociated fracture in Korea", The Korean Society of Bone Metabolism Seminar (2007)
- Korea National Statistical Office, "Korea National Statistical Office", ~ (2006)
- Gibson LJ, "The mechanical behaviour of cancellous bone", J Biomech, 18, pp.317~328 (1985)
- Choi K, "A comparison of the fatigue behavior of human trabecular and cortical bone tissue", J Biomech, 25, pp.1371~1381 (1992)
- Keaveny TM, "Differences between the tensile and compressive strengths of bovine tibial trabecular bone depend on modulus", J Biomech, 27, pp.1137~1146 (1994)
- Behrens JC, "Variations in strength and structure of cancellous bone at the knee", J Biomech, 7, pp.201~207 (1974)
- Hvid I, "Trabecular bone strength patterns at the proximal tibial epiphysis", J Orthop Res, 3, pp.464~472 (1985)
- Weinans H, "The behavior of adaptive bone-remodeling simulation models", J Biomech, 25, pp.1425~1441 (1992)
- Ulrich D, "Finite element analysis of trabecular bone structure: a comparison of image-based meshing techniques", J Biomech, 31, pp.1187~1192 (1998)
- van Rietbergen B, "A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models", J Biomech, 28, pp.69~81 (1995)
- Whitehouse WJ, "The quantitative morphology of anisotropic trabecular bone", J Microsc, 101, pp.153~168 (1974)
- Parfitt AM, "Bone histomorphology: Standarization of Nomenclature, Symbols, and Unit", J Bone Miner Res, 2, pp.595~610 (1987)
- Hildebrand T, "Quantification of bone microarchitecture with the structure model index", Comput Methods Biomech Biomed Engin, 1, pp.15~23 (1997)
- Ladd AJ, "Finite-element modeling of trabecular bone: comparison with mechanical testing and determination of tissue modulus", J Orthop Res, 16, pp.622~628 (1998)
- Keaveny TM, "Differences between the tensile and compressive strengths of bovine tibial trabecular bone depend on modulus", J Biomech, 27, pp.1137~1146 (1994)
- Keaveny TM, "Systematic and random errors in compression testing of trabecular bone", J Orthop Res, 15, pp.101~110 (1997)
- Marshall D, "Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures", BMJ, 312, pp.1254~1259 (1996)
- Taddei F, "An improved method for the automatic mapping of computed tomography numbers onto finite element models", Med Eng Phys, 26, pp.61~69 (2004)
- Keyak JH, "Automated three-dimensional finite element modelling of bone: a new method", J Biomed Eng, 12, pp.389~397 (1990)
- Keyak JH, "Validation of an automated method of threedimensional finite element modelling of bone", J Biomed Eng, 15, pp.505~509 (1993)
- Todd BA, "Three-dimensional computer model of the human buttocks, in vivo", J Rehavil Res Dev, 31, pp.111~119 (1994)
- Todd BA, "A visual basic program to pre-process MRI data for finite element modeling", Comput Biol Med, 26, pp.489~495 (1996)