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혈액과 모유 시료 중 과불화화합물 분석을 위한 전처리법 평가

Evaluation of Pretreatment Method for Analysis of Perfluorinated Compounds in Human Blood and Breast Milk Samples

이지현|김희영|오정은|김형식|심원진|이응선
한국환경분석학회 (The Korean Society For Environmental Analysis)|2011.03|환경분석과 독성보건 (JOURNAL OF ENVIRONMENTAL ANALYSIS, HEALTH AND TOXICOLOGY)|제14권 제1호|pp. 45-54

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참고문헌

키워드

PFCsbreast milkhuman bloodIPESPE

초록

In this study, we evaluated extraction methods for the analysis of perfluorinated compounds (PFCs) in human serum and breast milk samples. The recovery efficiencies of ion pairing extraction (IPE) and solid phase extraction (SPE) in each serum and breast milk were examined. For serum samples, IPE was more efficient (recovery efficiency: 81-105%) than SPE. For breast milk samples, except for perfluorododecanoic acid (PFDoA), SPE showed better recoveries (80-98%) than IPE. As results of validity test, accuracy and precision were in the range of 81~130% and 1~18% in serum, and 54~130% and 2~17% in breast milk, respectively. We also analyzed PFCs in the cord serum and breast milk from 13 pregnant women using the method established in this study. In the cord serum, all PFCs except for perfluorobutane sulfonate, perfluoroheptane sulfonate and perfluorohexanoic acid were detected. In the breast milk, perfluorooctane sulfonate, perfluorooctanoic acid and PFDoA were detected dominantly compared with other PFCs.

Abstract

In this study, we evaluated extraction methods for the analysis of perfluorinated compounds (PFCs) in human serum and breast milk samples. The recovery efficiencies of ion pairing extraction (IPE) and solid phase extraction (SPE) in each serum and breast milk were examined. For serum samples, IPE was more efficient (recovery efficiency: 81-105%) than SPE. For breast milk samples, except for perfluorododecanoic acid (PFDoA), SPE showed better recoveries (80-98%) than IPE. As results of validity test, accuracy and precision were in the range of 81~130% and 1~18% in serum, and 54~130% and 2~17% in breast milk, respectively. We also analyzed PFCs in the cord serum and breast milk from 13 pregnant women using the method established in this study. In the cord serum, all PFCs except for perfluorobutane sulfonate, perfluoroheptane sulfonate and perfluorohexanoic acid were detected. In the breast milk, perfluorooctane sulfonate, perfluorooctanoic acid and PFDoA were detected dominantly compared with other PFCs.

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