LC-HRMS 기반의 표적, 추정 및 비표적 분석기법을 활용한 우포늪 수계 내 미량오염물질 분석
Micropollutant Analysis in Upo Wetland via Target, Suspect and Nontarget Screening using LC-HRMS
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초록
Upo Wetland, in Changnyeong-gun, Gyeongsangnam-do, is the largest inland wetland in Korea and a habitat for various species. However, due to agricultural activities in the surrounding area, diverse organic pollutants such as pesticides have flowed into the wetland ecosystem. This study analyzed the exposure of Upo wetland to organic pollutants (e.g., pesticides and pharmaceuticals) using LC-HRMS (Liquid Chromatography-High Resolution Mass Spectrometry). Twenty-six pesticides and pharmaceuticals were selected and quantitatively analyzed for target screening. As a result, eight pharmaceuticals (e.g., fluconazole, lincomycin, metformin, valsartan) and eight pesticides (e.g., tebuconazole, metalaxyl) were quantitatively identified. The major pesticides were tebuconazole (230-3,900 ng/L) and metalaxyl (53-980 ng/L), whereas metformin (20-220 ng/L) was the pharmaceutical with the widest concentration range. Metabolites of the two major pesticides TEB_M324c and metalaxyl acid were identified tentatively via suspect and nontarget screening which also identified several other substances including benzotriazole, carbendazim, diazinon, hexaconazole, methabenzthiazuron, tricyclazole, niflumic acid, 2-aminobenzimidazole, 2-isopropyl-6-methyl-4-pyrimidinol, valsartan acid, and retrorsine.
Abstract
Upo Wetland, in Changnyeong-gun, Gyeongsangnam-do, is the largest inland wetland in Korea and a habitat for various species. However, due to agricultural activities in the surrounding area, diverse organic pollutants such as pesticides have flowed into the wetland ecosystem. This study analyzed the exposure of Upo wetland to organic pollutants (e.g., pesticides and pharmaceuticals) using LC-HRMS (Liquid Chromatography-High Resolution Mass Spectrometry). Twenty-six pesticides and pharmaceuticals were selected and quantitatively analyzed for target screening. As a result, eight pharmaceuticals (e.g., fluconazole, lincomycin, metformin, valsartan) and eight pesticides (e.g., tebuconazole, metalaxyl) were quantitatively identified. The major pesticides were tebuconazole (230-3,900 ng/L) and metalaxyl (53-980 ng/L), whereas metformin (20-220 ng/L) was the pharmaceutical with the widest concentration range. Metabolites of the two major pesticides TEB_M324c and metalaxyl acid were identified tentatively via suspect and nontarget screening which also identified several other substances including benzotriazole, carbendazim, diazinon, hexaconazole, methabenzthiazuron, tricyclazole, niflumic acid, 2-aminobenzimidazole, 2-isopropyl-6-methyl-4-pyrimidinol, valsartan acid, and retrorsine.
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