면역독성평가 대체시험법 개발을 위한 참조 시험물질 선정 방안
Selection of Reference test Substances to Develop Alternative Test Methods for Immunotoxicity Evaluation
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Alternative test method for screening immunotoxic substances has not been actively challenged and no test guideline has been officialized internationally. Preparation of master list on reference chemicals is a critical process for decision on positive or negative immunotoxicity of test substances through alternative test method. The reference master list is recommended to include various scopes of immuntoxic xenobiotics including medicinal products, cosmetic ingredients, and industrial or environmental agents. Data bases or research results on human or animal immunotoxicity of chemicals were collected and analyzed for preparing the list of reference chemicals. Twenty eight chemicals were selected as non-immunotoxicants, which could be used as negative controls for immunotoxicity and 10 immunosuppressive drugs were chosen for classifying immunosuppressive toxicity of test substances. Considering chemicals used as positive controls for immunotoxicity, 38 substances with aberrant immune regulatory capacity were listed, which are categorized into 23 industrial or environmental agents, 12 medicinal products, and 3 agrochemicals. The list of reference test substances could contribute to development of in vitro alternative assay method for immunotoxicity evaluation.
Abstract
Alternative test method for screening immunotoxic substances has not been actively challenged and no test guideline has been officialized internationally. Preparation of master list on reference chemicals is a critical process for decision on positive or negative immunotoxicity of test substances through alternative test method. The reference master list is recommended to include various scopes of immuntoxic xenobiotics including medicinal products, cosmetic ingredients, and industrial or environmental agents. Data bases or research results on human or animal immunotoxicity of chemicals were collected and analyzed for preparing the list of reference chemicals. Twenty eight chemicals were selected as non-immunotoxicants, which could be used as negative controls for immunotoxicity and 10 immunosuppressive drugs were chosen for classifying immunosuppressive toxicity of test substances. Considering chemicals used as positive controls for immunotoxicity, 38 substances with aberrant immune regulatory capacity were listed, which are categorized into 23 industrial or environmental agents, 12 medicinal products, and 3 agrochemicals. The list of reference test substances could contribute to development of in vitro alternative assay method for immunotoxicity evaluation.
참고문헌 (43)
- 식품의약품안전처, "의약품등의 독성시험기준 (식품의약품안전처 고시 제2017-71호)", ~ (2017)
- 환경부, "제한물질.금지물질의 지정 (환경부고시 제2019-214호)", ~ (2019)
- Aschner M, "Reference compounds for alternative test methods to indicate developmental neurotoxicity(DNT)potential of chemicals : example lists and criteria for their selection and use", ALTEX, 34, pp.49~74 (2017)
- ATSDR, "Toxicological profile for vanadium. Agency for Toxic Substances and Disease Registry", Agency for Toxic Substances and Disease Registry, ~ (2012)
- Chen Y, "Research progress of mTOR inhibitors", Eur. J. Med. Chem, 208, pp.112820~ (2020)
- Costa S, "Occupational exposure to formaldehyde and early biomarkers of cancer risk, immunotoxicity and susceptibility", Env. Res, 179, pp.108740~ (2019)
- Davila DR, "Human T cells are highly sensitive to suppression of mitogenesis by polycyclic aromatic hydrocarbons and this effect is differentially reversed by α–naphthoflavone", Tox. Appl. Phamacol, 139, pp.333~341 (1996)
- Dhouib IB, "Carbamate pesticides induced immunotoxicity and carcinogenecity in human : a review", J. Appl. Biomed, 14, pp.85~90 (2016)
- Diehl R, "Immunosuppression for in vivo research : state-of-the-art protocols and experimental approaches", Cell. Mol. Immunol, 14, pp.146~179 (2017)
- El-Gohary M, "Effect of cannabinoid ingestion(in the form of bhang)on the immune system of high school and university students", Hum. Exp. Toxicol, 23, pp.149~156 (2004)
- EMA, "ICH Topic S 8 Immunotoxicities studies for human pharmaceuticals", European Medicines Agency, ~ (2006)
- EPA, "Biochemical test guidelines OPPTS 880.3550Immunotoxicity", Government Printing Office, ~ (1996)
- EPA, "Provisional peer-reviewed toxicity values for isopropanol", ~ (2014)
- EURL ECVAM, "Non-animal methods in science and regulation-EURL ECVAM status report 2020" (2021), Publications Office of the European Union
- Forreryd A, "Prediction of chemical respiratory sensitizers using GARD, a novel in vitro assay based on a genomic biomarker signature", PLOS ONE, 2015, pp.0118808~ (2015)
- Gennari A, "The use of in vitro systems for evaluating immunotoxicity;the report and recommendations of an ECVAM workshop", J. Immunotox, 2, pp.61~83 (2005)
- Johansson H, "Validation of the GARD™ skin assay for assessment of chemical skin sensitizers : ring trial results of predictive performance and reproducibility", Toxcol. Sci, 170, pp.374~381 (2019)
- Johansson H, "A genomicbiomarker signaturecan predict skin sensitizers using a cell-based in vitro alternative to animal tests", BMC Genomics, 12, pp.399~ (2011)
- Jongeneel WP, "Health impact assessment of a skin sensitizer : analysis of potential policy measures aimed at reducing geraniol concentrations in personal care products and household cleaning products", Environ. Int, 118, pp.235~244 (2018)
- Jung KM, "Keraskin™-VM : a novel reconstructed human epidermis model for skin irritation tests", Toxicol. in Vitro, 28, pp.742~750 (2014)
- Jung D, "Discrimination of skin sensitizers from non-sensitizers by interleukin-1α and interleukin-6production on cultured human keratinocytes", J. Appl. Toxicol, 36, pp.1129~1136 (2016)
- Kapp RW, "Reproductive toxicology" (2019), CRC press
- Boca Raton, "Evaluation of the Multi-ImmunoTox assay composed of 3 human cytokine reporter cells by examining immunological effects of drugs", Toxicol, In Vitro, 28, pp.759~768 (2014)
- Kimura Y, "Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay", Arch. Toxicol, 92, pp.2043~2054 (2018)
- Kimura Y, "An international validation study of the IL-2 Luc assay for evaluating the potential immunotoxic effects of chemicals on T cells and a proposal for reference data for immunotoxic chemicals", Toxicol, In Vitro, 66, pp.104832~ (2020)
- Langezaal I, "Whole blood cytokine response as a measure of immunotoxicity", Toxicol. In Vitro, 15, pp.313~318 (2001)
- Luster MI, "Development of a testing battery to assess chemical-induced immunotoxicity : National Toxicology Program’s guidelines for immunotoxicity evaluation in mice", Fundam. Appl. Toxicol, 10, pp.2~19 (1988)
- Luster MI, "Risk assessment in immunotoxicology I. sensitivity andpredictability of immune tests", Fundam. Appl. Toxicol, 18, pp.200~210 (1992)
- Luster MI, "Fundam", Appl. Toxicol, 21, pp.71~82 (1993)
- Manley K, "Crosstalk between the immune, endocrine, and nervous systems in immunotoxicology", Curr. Opin. in Toxicol, 10, pp.37~45 (2018)
- Markovič T, "Characterization of human lymphoblastoid cell lines as a novel in vitro test system to predict the immunotoxicity of xenobiotics", Toxicol. Lett, 233, pp.8~15 (2015)
- Maria Meneghini, "Immunosuppressive drugs modes of action", Best Practice & Research Clinical Gastroenterology, 54-55, pp.101757~ (2021), Elsevier BV[DOI]
- Naidenko OV, "Investigating molecular mechanisms of immunotoxicity and the utility of ToxCast for immuotoxicity screening of chemicals added to food", Int. J. Environ. Res. Public Health, 18, pp.3332~ (2001)
- OECD, ". Test No. 429 : OECD guideline for the testing of chemicals : skin sensitization : Local Lymph Node Assay" (2010), OECD Publishing
- OECD, "OECD series on testing and assessment, No. 286" (2018), OECD Publishing
- OECD., "Test No. 442E: In vitro skin sensitisation. In vitro skin sensitization assays addressing the key event on activation of dendritic cells on the adverse outcome pathway for skin sensitisation" (2018), OECD Publishing
- Rovida C, "Advanced tests for skin and respiratory sensitization assessment", ALTEX, 30, pp.231~252 (2013)
- Scherholz ML, "Chronopharmacology of glucocorticoids", Adv. Drug Deliv. Rev, 51-152, pp.245~261 (2019)
- U. S. Congress, "Identifying & Controlling immunotoxic substances-background paper" (1991), Office of Technology Assessment, U.S. Government Printing Office
- Veraldi A, "Immunotoxic effects of chemicals : a matrix for occupational and environmental epidemiological studies", Am. J. Ind. Med, 49, pp.1046~1055 (2006)
- Vos JG, "Immune suppression as related to toxicology", Crit. Rev. Toxicol, 5, pp.67~101 (1977)
- WHO, "Guidance for immunotoxicity risk assessment for chemicals", World Health Organization, ~ (2012)
- Zhang W, "Recent topics on the mechanisms of immunosuppressive therapy-related neurotoxicities", Int. J. Mol. Sci, 20, pp.3210~ (2019)
