한국성인의 근감소증과 류마티스 관절염 및 골관절염의 관련성: 국민건강영양조사 2008-2011
Associations of Sarcopenia with Rheumatoid Arthritis and Osteoarthritis in Korean Adults: the Korea National Health and Nutrition Examination Survey 2008-2011
0
조회
0
다운로드
2
인용
0
참고문헌
키워드
초록
[PURPOSE] This study aimed to investigate the associations of sarcopenia with rheumatoid arthritis and osteoarthritis in the general population of Korean adults. [METHODS] We analyzed the data for 11,466 adults aged ≥40 years from the Korea National Health and Nutrition Examination Survey 2008-2011. Dual-energy X-ray absorptiometry was used to measure the skeletal muscle mass. Sarcopenia was defined when the appendicular skeletal muscle index was less than the sex-specific average minus the two standard deviations in the young reference group(age, 20-39 years). Survey logistic regression analysis was used to assess the association of sarcopenia with rheumatoid arthritis and osteoarthritis. [RESULTS] Sarcopenia status was dose-dependently associated with a higher risk of rheumatoid arthritis, after adjustment for potential confounders(p-trend=.002, odds ratio [OR], 2.14; 95% confidence interval [CI], 1.13, 4.05 in sarcopenia group vs. high muscle mass group). However, a higher risk of osteoarthritis was observed in pre-sarcopenia group compared with the high muscle mass group(OR, 1.45; 95% CI, 1.03, 2.05), but not in sarcopenia group. [CONCLUSIONS] We found that sarcopenia status was associated with rheumatoid arthritis, and pre-sarcopenia status was associated with osteoarthritis. Our findings suggest that maintaining a skeletal muscle could be beneficial in preventing musculoskeletal disorders, including rheumatoid arthritis and osteoarthritis.
Abstract
[PURPOSE] This study aimed to investigate the associations of sarcopenia with rheumatoid arthritis and osteoarthritis in the general population of Korean adults. [METHODS] We analyzed the data for 11,466 adults aged ≥40 years from the Korea National Health and Nutrition Examination Survey 2008-2011. Dual-energy X-ray absorptiometry was used to measure the skeletal muscle mass. Sarcopenia was defined when the appendicular skeletal muscle index was less than the sex-specific average minus the two standard deviations in the young reference group(age, 20-39 years). Survey logistic regression analysis was used to assess the association of sarcopenia with rheumatoid arthritis and osteoarthritis. [RESULTS] Sarcopenia status was dose-dependently associated with a higher risk of rheumatoid arthritis, after adjustment for potential confounders(p-trend=.002, odds ratio [OR], 2.14; 95% confidence interval [CI], 1.13, 4.05 in sarcopenia group vs. high muscle mass group). However, a higher risk of osteoarthritis was observed in pre-sarcopenia group compared with the high muscle mass group(OR, 1.45; 95% CI, 1.03, 2.05), but not in sarcopenia group. [CONCLUSIONS] We found that sarcopenia status was associated with rheumatoid arthritis, and pre-sarcopenia status was associated with osteoarthritis. Our findings suggest that maintaining a skeletal muscle could be beneficial in preventing musculoskeletal disorders, including rheumatoid arthritis and osteoarthritis.
참고문헌 (35)
- Alamanos, Y, "Epidemiology of adult rheumatoid arthritis", Autoimmunity Reviews, 4(3), pp.130~136 (2005)
- Anderson, A. S, "Why is osteoarthritis an age-related disease?", Best Practice & Research Clinical Rheumatology, 24(1), pp.15~26 (2010)
- Baumgartner, R. N, "Epidemiology of sarcopenia among the elderly in New Mexico", American Journal of Epidemiology, 147(8), pp.755~763 (1998)
- Biolo, G, "Muscle contractile and metabolic dysfunction is a common feature of sarcopenia of aging and chronic diseases: from sarcopenic obesity to cachexia", Clinical Nutrition, 33(5), pp.737~748 (2014)
- Burner, T. W, "Diabetes and rheumatic diseases", Current Opinion in Rheumatology, 21(1), pp.50~54 (2009)
- Chang, S. F, "Systematic literature review and meta-analysis of the association of sarcopenia With mortality", Worldviews on Evidence-based Nursing, 13(2), pp.153~162 (2016)
- Coggon, D, "Occupational physical activities and osteoarthritis of the knee", Arthritis and Rheumatism, 43(7), pp.1443~1449 (2000)
- Crowson, C. S, "Rheumatoid arthritis and cardiovascular disease", American Heart Journal, 166(4), pp.622~628.e1 (2013)
- Doğan, S. C, "Sarcopenia in women with rheumatoid arthritis", European Journal of Rheumatology, 2(2), pp.57~ (2015)
- Eckardt, K, "Myokines in insulin resistance and type 2diabetes", Diabetologia, 57(6), pp.1087~1099 (2014)
- Fougere, B, "Chronic inflammation:accelerator of biological aging", The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, pp.glw240~ (2016)
- Giles, J. T, "Abnormal body composition phenotypes in older rheumatoid arthritis patients: association with disease characteristics and pharmacotherapies", Arthritis Care & Research, 59(6), pp.807~815 (2008)
- Goodpaster, B. H, "The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study", The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 61(10), pp.1059~1064 (2006)
- Guerne, P. -A, "Synovium as a source of interleukin 6 in vitro. contribution to local and systemic manifestations of arthritis", Journal of Clinical Investigation, 83(2), pp.585~ (1989)
- 허남욱, "국민건강영양조사를 이용한 한국인 관절염의 유병률 현황과 연도별 변화", 대한류마티스학회지, 15(1), pp.11~26 (2008), 대한류마티스학회
- Janssen, I, "Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability", Journal of the American Geriatrics Society, 50(5), pp.889~896 (2002)
- Kalyani, R. R, "Age-related and disease-related muscle loss:the effect of diabetes, obesity, and other diseases", The Lancet Diabetes & Endocrinology, 2(10), pp.819~829 (2014)
- 강선영, "Association between Sarcopenic Obesity and Metabolic Syndrome in Postmenopausal Women: A Cross-sectional Study Based on the Korean National Health and Nutritional Examination Surveys from 2008 to 2011", 대한골대사학회지, 24(1), pp.9~14 (2017), 대한골대사학회[DOI]
- "Prevalence of osteoarthritis among adults over 50 years old in Korea, 2010-2013" (2015)[URL]
- Kramer, H. R, "Muscle density in rheumatoid arthritis: associations with disease features and functional outcomes", Arthritis &Rheumatism, 64(8), pp.2438~2450 (2012)
- Jeong-Mi Kwon, "Socioeconomic and Employment Status of Patients with Rheumatoid Arthritis in Korea", Epidemiology and Health, 34, pp.1~7 (2012), 한국역학회
- Landi, F, "Sarcopenia as a risk factor for falls in elderly individuals: results from the ilSIRENTE study", Clinical Nutrition, 31(5), pp.652~658 (2012)
- 이혜상, "우리나라 노인의 건강관련 삶의 질에 영향을 주는 요인- 일반 특성, 생활습관, 정신건강, 만성질환, 영양섭취상태를 중심으로: 제5기 국민건강영양조사자료, 2010~2012", 대한지역사회영양학회지, 19(5), pp.479~489 (2014), 대한지역사회영양학회
- Maggio, M, "Interleukin-6 in aging and chronic disease: a magnificent pathway", The Journals of Gerontology series A: Biological Sciences and Medical Sciences, 61(6), pp.575~584 (2006)
- Mitchell, W. K, "Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review", Frontiers in Physiology, 3, pp.260~ (2012)
- "The physical activity guide for koreans" (2013)[URL]
- Morley, J. E, "Sarcopenia in the elderly", Family Practice, 29(suppl 1), pp.I44~I48 (2012)
- Morley, J. E, "Sarcopenia", Journal of Laboratory and Clinical Medicine, 137(4), pp.231~243 (2001)
- Pedersen, B. K, "Muscles, exercise and obesity: skeletal muscle as a secretory organ", Nature Reviews Endocrinology, 8(8), pp.457~465 (2012)
- Rantanen, T, "Muscle strength, disability and mortality", Scandinavian Journal of Medicine &Science in Sports, 13(1), pp.3~8 (2003)
- Schlaak, J, "Different cytokine profiles in the synovial fluid of patients with osteoarthritis, rheumatoid arthritis and seronegative spondylarthropathies", Clinical and Experimental Rheumatology, 14(2), pp.155~162 (1995)
- Scott, D, "Prospective study of self-reported pain, radiographic osteoarthritis, sarcopenia progression, and falls risk in community-dwelling older adults", Arthritis Care & Research, 64(1), pp.30~37 (2012)
- Sellam, J, "Is osteoarthritis a metabolic disease", Joint Bone Spine, 80(6), pp.568~573 (2013)
- "Population projections for Korea : 2015 ~ 2065" (2016)[URL]
- Verschueren, S, "Sarcopenia and its relationship with bone mineral density in middle-aged and elderly European men", Osteoporosis International, 24(1), pp.87~98 (2013)