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지역사회 거주 한국인 노년 성인에서 근감소증과 골밀도와의 관계

The Relationship between Sarcopenia and Bone Mineral Density in Community-Dwelling Korean Older Adults

정동진|조정란
한국컴퓨터정보학회 (The Korean Society Of Computer And Information)|2023.06|한국컴퓨터정보학회논문지 (Journal of The Korea Society of Computer and Information)|제28권 제6호|pp. 113-123|DOI https://doi.org/10.9708/jksci.2023.28.06.113

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참고문헌

키워드

국민건강영양조사KNHANES골다공증골밀도fracturebone mineral density근감소증osteoporosissarcopenia골절
주제분류컴퓨터학

초록

근감소증은 진행성 골격근 질환으로서 낙상, 골절, 심혈관 및 대사질환 등과 관련이 있다. 본연구에서는 전국민을 대상으로 한 질병관리본부의 국민건강영양조사 (KNHANES) 2008-2011년 자료를 이용하여 지역사회 거주 남녀를 대상으로 근감소증과 골밀도와의 관련성에 대하여 분석하였다. 골다공증에 대한 약물을 투여받고 있거나 골대사에 영향을 미치는 질환 또는 악성종양이 있는 경우에는 제외하였다. 근감소증은 개정된 AWGS (Asian Working Group for Sarcopenia)의 기준에 따라 SMI (Skeletal Muscle Index) 가 남성에서는 <7.0 kg/m2, 여성에서는 <5.4 kg/m2 인 경우로정의하였다. 50세 이상 성인 남성 1,246명 및 폐경후여성 887명 등, 총 2,133명이 본 연구대상에포함되었다. 근감소증의 유병율은 남성 (28.8%)에서 여성(22.0%)에 비해 유의하게 높게 나타났다. 연령을 비롯한 다양한 혼란변수들에 대해 보정한 다중회귀분석을 시행한 결과, 남성에서는 근감소증이 요추 및 대퇴골 모두에서 낮은 골밀도와 관련이 있었고 여성에서는 관련이 없었다. 결론적으로 50세 이상의 한국인 남성에서 근감소증은 낮은 골밀도와 관련이 있었다.

Abstract

Sarcopenia is a progressive skeletal muscle disorder associated with poor health outcomes such as falls, fractures, cardiovascular and metabolic disease. In this study, we used nation-wide data from 2008 to 2011 Korea National Health and Nutrition Examination Survey (KNHANES) to analyze the association between bone mineral density (BMD) and sarcopenia in community-dwelling men and women. Subjects with history of medication for osteoporosis or with illness or malignancy affecting bone metabolism were excluded. Sarcopenia was defined using the revised Asian Working Group for Sarcopenia (AWGS) classification with SMI (skeletal muscle index; <7.0 kg/m2 for men and <5.4 kg/m2 for women). We included 2,133 subjects aged 50 years or older men (N=1,246) and postmenopausal women (N=887). Prevalence of sarcopenia was significantly higher in men (28.8%) than women (22.0%). In multiple regression analysis, sarcopenia was significantly associated with low bone mass at the lumbar spine, femur neck and total femur BMD after adjusting confounding factors in men. However, there was no association between sarcopenia and bone mass in women. In conclusion, sarcopenia is significantly related to low bone mass, especially in men aged ≥50 years in Korea.

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