만성 비세균성 전립선염 환자의 전립선액에서 interleukin-1β의 변화
Changes of Interleukin-1β in the Prostate Secretions of Chronic Nonbacterial Prostatitis Patients
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose: To measure changes in prostate cytokine secretion in chronic non-bacterial prostatitis (NBP) patients and examine the clinical usefulness of these changes in differentiating the pathophysiologic mechanism of NBP and subsequent selection of treatment modalities. Materials and Methods: Sixty male patients were diagnosed with chronic NBP, and a control group comprised of 30 male patients without clinical evidence of NBP were enrolled in this study. Prostate secretion (centrifuged VB3) was analyzed at the initialdiagnosis and 8 weeks after treatment initiation. Patients who showed more than 10 white blood cells (WBCs)/high power field (HPF) 8 weeks after treatment initiation were categorized into group A. Group B patients had less than 3 WBCs/HPF. Group B was further subclassified into two groups according to presence of symptoms after treatment: Bp (symptom-persisted) and Br (symptom-resolved). IL-1β, C3, C4, IgG were measured and the results were analyzed. Results: There were significant differences in the IL-1β level in the control group compared to group A, Bp and Br (p<0.05). C3, C4, IgG showed higher levels in groups A and B than in the control group, albeit without statistical significance (p>0.05). Conclusions: Elevated IL-1β in group Bp suggests that chronic NBP patients who did not respond to treatment could exhibitclinical manifestations of autoimmune reactions rather than infection of external origin. We suggest that a more advanced diagnostic technique using cytokine at the initial stage of disease manifestation tohelp clinicians avoid unnecessary antibiotic treatment and manage the condition more effectively.
Abstract
Purpose: To measure changes in prostate cytokine secretion in chronic non-bacterial prostatitis (NBP) patients and examine the clinical usefulness of these changes in differentiating the pathophysiologic mechanism of NBP and subsequent selection of treatment modalities. Materials and Methods: Sixty male patients were diagnosed with chronic NBP, and a control group comprised of 30 male patients without clinical evidence of NBP were enrolled in this study. Prostate secretion (centrifuged VB3) was analyzed at the initialdiagnosis and 8 weeks after treatment initiation. Patients who showed more than 10 white blood cells (WBCs)/high power field (HPF) 8 weeks after treatment initiation were categorized into group A. Group B patients had less than 3 WBCs/HPF. Group B was further subclassified into two groups according to presence of symptoms after treatment: Bp (symptom-persisted) and Br (symptom-resolved). IL-1β, C3, C4, IgG were measured and the results were analyzed. Results: There were significant differences in the IL-1β level in the control group compared to group A, Bp and Br (p<0.05). C3, C4, IgG showed higher levels in groups A and B than in the control group, albeit without statistical significance (p>0.05). Conclusions: Elevated IL-1β in group Bp suggests that chronic NBP patients who did not respond to treatment could exhibitclinical manifestations of autoimmune reactions rather than infection of external origin. We suggest that a more advanced diagnostic technique using cytokine at the initial stage of disease manifestation tohelp clinicians avoid unnecessary antibiotic treatment and manage the condition more effectively.
참고문헌 (21)
- Krieger JN, "NIH consensus definition and classification of prostatitis", JAMA, 282, pp.236~237 (1999)
- Hochreiter WW, "Evaluation of the cytokines interleukin 8 and epithelial neutrophil activating peptide 78 as indicators of inflammation in prostatic secretions", Urology, 56, pp.1025~1029 (2000)
- Tomaskovic I, "Chronic prostatitis", chronic pelvic pain syndrome in males may be an autoimmune disease, potentially responsive to corticosteroid therapy, 2009, pp.72, 261~262
- John H, "Noninflammatory chronic pelvic pain syndrome: immunological study in blood, ejaculate and prostate tissue", Eur Urol, 39, pp.72~78 (2001)
- Kohnen PW, "Patterns of inflammation in prostatic hyperplasia: a histologic and bacteriologic study", J Urol, 121, pp.755~760 (1979)
- Kramer G, "Is benign prostatic hyperplasia (BPH) an immune inflammatory disease?", Eur Urol, 51, pp.1202~1216 (2007)
- Hopp TP, "The molecular form of interleukin-1", Immunol Res, 5, pp.271~280 (1986)
- Grassi J, "Determination of IL 1 alpha, IL 1 beta and IL2 in biological media using specific enzyme immunometric assays", Immunol Rev, 119, pp.125~145 (1991)
- Murphy AB, "Pharmacotherapy strategies in chronic prostatitis", chronic pelvic pain syndrome management, 2010, pp.11, 1255~1261
- Nickel JC, "Antibiotic therapy for chronic inflammatory (NIH category II", IIIA) prostatitis (abstract), 1998, pp.159(5), 272~
- Wiygul RD, "Prostatitis: epidemiology of inflammation", Curr Urol Rep, 6, pp.282~289 (2005)
- Pontari MA, "Mechanisms in prostatitis", chronic pelvic pain syndrome, 2004, pp.172, 839~845
- A Pontari M, "Inflammation and anti-inflammatory therapy in chronic prostatitis", Urology, 60(6), pp.29~33 (2002)
- Rivero VE, "Autoimmune etiology in chronic prostatitis syndrome: an advance in the understanding of this pathology", Crit Rev Immunol, 27, pp.33~46 (2007)
- Motrich RD, "Pathogenic consequences in semen quality of an autoimmune response against the prostate gland: from animal models to human disease", J Immunol, 177, pp.957~967 (2006)
- Karlovsky ME, "Theories of prostatitis etiology", Curr Urol Rep, 3, pp.307~312 (2002)
- Shoskes DA, "Cytokine polymorphisms in men with chronic prostatitis", chronic pelvic pain syndrome: association with diagnosis and treatment response, 2002, pp.168, 331~335
- Halloran MM, "The role of an epithelial neutrophil-activating peptide-78-like protein in rat adjuvant- induced arthritis", J Immunol, 162, pp.7492~7500 (1999)
- Ponniah S, "PSA is a candidate self-antigen in autoimmune chronic prostatitis", chronic pelvic pain syndrome, 2000, pp.44, 49~54
- Bai J, "Characterization of circulating CD4+CD25high regulatory T cells in men with chronic prostatitis", chronic pelvic pain syndrome, 2010, pp.75, 938~942
- Tomaskovic I, "Chronic prostatitis", chronic pelvic pain syndrome in males may be an autoimmune disease, potentially responsive to corticosteroid therapy, 2009, pp.72, 261~262