Effects of Gamdutang on Protection Against Accumulation of Cadmium in Rats
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초록
This experiments were conducted to determine the effects of Gamdutang on the accumulation of cadmium in the body of rats received an 8-week administration of 1.7, 3.4 and 6.8 μg/g/day of cadmium, respectively, while other groups of rats received an 8-week administration of a mixture of cadmium by concentration and Gamdutang. A comparative analysis of these groups was conducted in respect of weight, accumulated cadmium amounts in blood and diverse organs and pathological findings of the kidneys. As for the cadmium accumulation in blood, the livers, the kidneys, and the testis, with the lengthening of the experiment period, the cadmium and Gamdutang mixtureadministered groups tended to reduce the accumulation levels compared with the cadmium exclusively administered groups. As a result of histopathological observation of the kidneys, observed in the cadmium exclusively administered groups were hemorrhagic necrosis in glomeruli, the swelling of tubules, epithelial shedding and necrosis of tubules; however, mild tissue lesions were observed in the cadmium and Gamdutang mixtureadministered groups. Give above results, Gamdutang is deemed to have the effects of restraining the accumulation of cadmium in blood, the liver, and the testis when low-concentration cadmium is administered to rats.
Abstract
This experiments were conducted to determine the effects of Gamdutang on the accumulation of cadmium in the body of rats received an 8-week administration of 1.7, 3.4 and 6.8 μg/g/day of cadmium, respectively, while other groups of rats received an 8-week administration of a mixture of cadmium by concentration and Gamdutang. A comparative analysis of these groups was conducted in respect of weight, accumulated cadmium amounts in blood and diverse organs and pathological findings of the kidneys. As for the cadmium accumulation in blood, the livers, the kidneys, and the testis, with the lengthening of the experiment period, the cadmium and Gamdutang mixtureadministered groups tended to reduce the accumulation levels compared with the cadmium exclusively administered groups. As a result of histopathological observation of the kidneys, observed in the cadmium exclusively administered groups were hemorrhagic necrosis in glomeruli, the swelling of tubules, epithelial shedding and necrosis of tubules; however, mild tissue lesions were observed in the cadmium and Gamdutang mixtureadministered groups. Give above results, Gamdutang is deemed to have the effects of restraining the accumulation of cadmium in blood, the liver, and the testis when low-concentration cadmium is administered to rats.
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