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Emerging role of Hippo pathway in the regulation of hematopoiesis

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In various organisms, the Hippo signaling pathway has beenidentified as a master regulator of organ size determination andtissue homeostasis. The Hippo signaling coordinates embryonicdevelopment, tissue regeneration and differentiation, throughregulating cell proliferation and survival. The YAP and TAZ(YAP/TAZ) act as core transducers of the Hippo pathway, andthey are tightly and exquisitely regulated in response to variousintrinsic and extrinsic stimuli. Abnormal regulation or geneticvariation of the Hippo pathway causes a wide range of humandiseases, including cancer. Recent studies have revealed thatHippo signaling plays a pivotal role in the immune system andcancer immunity. Due to pathophysiological importance, theemerging role of Hippo signaling in blood cell differentiation,known as hematopoiesis, is receiving much attention. A numberof elegant studies using a genetically engineered mouse (GEM)model have shed light on the mechanistic and physiologicalinsights into the Hippo pathway in the regulation of hematopoiesis. Here, we briefly review the function of Hippo signalingin the regulation of hematopoiesis and immune cell differentiation.

Abstract

In various organisms, the Hippo signaling pathway has beenidentified as a master regulator of organ size determination andtissue homeostasis. The Hippo signaling coordinates embryonicdevelopment, tissue regeneration and differentiation, throughregulating cell proliferation and survival. The YAP and TAZ(YAP/TAZ) act as core transducers of the Hippo pathway, andthey are tightly and exquisitely regulated in response to variousintrinsic and extrinsic stimuli. Abnormal regulation or geneticvariation of the Hippo pathway causes a wide range of humandiseases, including cancer. Recent studies have revealed thatHippo signaling plays a pivotal role in the immune system andcancer immunity. Due to pathophysiological importance, theemerging role of Hippo signaling in blood cell differentiation,known as hematopoiesis, is receiving much attention. A numberof elegant studies using a genetically engineered mouse (GEM)model have shed light on the mechanistic and physiologicalinsights into the Hippo pathway in the regulation of hematopoiesis. Here, we briefly review the function of Hippo signalingin the regulation of hematopoiesis and immune cell differentiation.

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