Multifaceted roles of CCAR family proteins in the DNA damage response and cancer

참고문헌 (67)

1. Iyer, D. R., "CCAR2 functions downstream of the Shieldin complex to promote double-strand break end-joining", Proc. Natl Acad. Sci. USA, 119, pp.e2214935119~ (2022)
2. Brunquell, J., "DBC1", CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor, 2014, pp.2014, 418458~
3. Rajendran, P., "Acetylation of CCAR2 Establishes a BET", BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition, 2019, pp.79, 918~927
4. Zheng, H., "hMOF acetylation of DBC1", CCAR2 prevents binding and inhibi tion of SirT1, 2013, pp.33, 4960~4970
5. Kong, S., "Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKalpha Phosphorylation", J. Immunol, 195, pp.3685~3693 (2015)
6. Anantharaman, V. & Aravind, L., "Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites", Cell Cycle, 7, pp.1467~1472 (2008)
7. Chazin, W. J., "Relating form and function of EF-hand calcium binding proteins", Acc. Chem. Res, 44, pp.171~179 (2011)
8. Chini, E. N., "Deleted in breast cancer-1 (DBC-1) in the interface between metabolism, aging and cancer", Biosci. Rep, 33 (2013)[DOI]
9. Chen, C., "Nuclear Import of Arabidopsis Poly(ADP-Ribose)Polymerase 2 Is Mediated by Importin-alpha and a Nuclear Localization Sequence Located Between the Predicted SAP Domains", Front Plant Sci, 9, pp.1581~ (2018)
10. Hnizda, A., "SAP domain forms a flexible part of DNA aperture in Ku70", 80, 2021, pp.288, 4382~4393
11. Notenboom, V., "Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification", Nucleic Acids Res, 35, pp.5819~5830 (2007)
12. Kim, H. J., "DBC1 is a key positive regulator of enhancer epigenomic writers KMT2D and p300", Nucleic Acids Res, 50, pp.7873~7888 (2022)
13. Kim, J. E., "DBC1 is a negative regulator of SIRT1", Nature, 451, pp.583~586 (2008)
14. Zhao, W., "Negative regulation of the deacetylase SIRT1 by DBC1", Nature, 451, pp.587~590 (2008)
15. Magni, M., "CCAR2", DBC1 is required for Chk2-dependent KAP1 phosphor ylation and repair of DNA damage, 2015, pp.6, 17817~17831
16. Park, J. H., "Modification of DBC1 by SUMO2", 3 is crucial for p53-mediated apoptosis in response to DNA damage, 2014, pp.5, 5483~
17. Gao, J., "SENP1-Mediated Desumoylation of DBC1Inhibits Apoptosis Induced by High Glucose in Bovine Retinal Pericytes", J. Oph thalmol, 2016, pp.6392658~ (2016)
18. Kang, H., "Peptide switch is essential for Sirt1 deacetylase activity", Mol. Cell, 44, pp.203~213 (2011)
19. Nin, V., "Role of deleted in breast cancer 1(DBC1)protein in SIRT1 deace tylase activation induced by protein kinase A and AMP-activated protein kinase", J. Biol. Chem, 287, pp.23489~23501 (2012)
20. Raynes, R., "The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response", PLoS One, 8, pp.e54364~ (2013)
21. Brunquell, J., "CCAR-1 is a negative regulator of the heat-shock response in Caenorhabditis elegans", Aging Cell, 17, pp.e12813~ (2018)
22. Kim, W., "Mitochondrial CCAR2", DBC1 is required for cell survival against rotenone-induced mitochondrial stress, 2017, pp.485, 782~789
23. Kolobova, E., "Microtubule-dependent association of AKAP350A and CCAR1with RNA stress granules", Exp. Cell Res, 315, pp.542~555 (2009)
24. Zannini, L., "DBC1 phosphorylation by ATM", ATR inhibits SIRT1 deacetylase in response to DNA damage, 2012, pp.4, 294~303
25. Yuan, J., "Regulation of SIRT1 activity by genotoxic stress", Genes Dev, 26, pp.791~796 (2012)
26. Li, J., "A conserved NAD(+)binding pocket that regulates protein-protein interactions during aging", Science, 355, pp.1312~1317 (2017)
27. Eustermann, S., "The DNA-binding domain of human PARP-1 interacts with DNA single-strand breaks as a monomer through its second zinc finger", J. Mol. Biol, 407, pp.149~170 (2011)
28. Rajman, L., "Therapeutic Potential of NAD-Boosting Molecules : The In Vivo Evidence", Cell Metab, 27, pp.529~547 (2018)
29. Magni, M., "Cell cycle and apoptosis regulator 2 at the interface between DNA damage response and cell physiology", Mutat. Res Rev. Mutat. Res, 776, pp.1~9 (2018)
30. Kim, J. E., "Interactions between DBC1 and SIRT 1 are deregu lated in breast cancer cells", Cell Cycle, 8, pp.3784~3785 (2009)
31. Ceccaldi, R., "Repair Pathway Choices and Con sequences at the Double-Strand Break", Trends Cell Biol, 26, pp.52~64 (2016)
32. Scully, R., "DNAdouble-strandbreakrepair-pathway choice in somatic mammalian cells", Nat. Rev. Mol. Cell Biol, 20, pp.698~714 (2019)
33. Stinson, B. M., "Repair of DNA Double-Strand Breaks by the Non homologous End Joining Pathway", Annu Rev. Biochem, 90, pp.137~164 (2021)
34. Dev, H., "Shieldin complex promotes DNA end-joining and counters homo logous recombination in BRCA1-null cells", Nat. Cell Biol, 20, pp.954~965 (2018)
35. Ghezraoui, H., "53BP1 cooperation with the REV7-shieldin complex underpins DNA structure-specific NHEJ", Nature, 560, pp.122~127 (2018)
36. Gupta, R., "DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity", Cell, 173, pp.972~988 (2018)
37. Mirman, Z., "53BP1-RIF1-shieldin counteracts DSB resection through CST-and Polalpha-dependent fill-in", Nature, 560, pp.112~116 (2018)
38. Lopez-Saavedra, A., "A genome-wide screening uncovers the role of CCAR2as an antagonist of DNA end resection", Nat. Commun, 7, pp.12364~ (2016)
39. Hiraike, H., "Identification of DBC1 as a transcriptional repressor for BRCA1", Br. J. Cancer, 102, pp.1061~1067 (2010)
40. Ayrapetov, M. K., "DNA double strand breaks promote methylation of histone H3 on lysine 9 and transient for mation of repressive chromatin", Proc. Natl Acad. Sci. USA, 111, pp.9169~9174 (2014)
41. Li, Z., "Inhibition of SUV39H1 methyltransferase activity by DBC1", J. Biol. Chem, 284, pp.10361~10366 (2009)
42. Chini, C. C., "HDAC3 is negatively regulated by the nuclear protein DBC1", J. Biol. Chem, 285, pp.40830~40837 (2010)
43. Hamaguchi, M., "DBC2, a candidate for a tumor suppressor gene involved in breast cancer", Proc. Natl Acad. Sci. USA, 99, pp.13647~13652 (2002)
44. Johnson, G. S., "CCAR1 and CCAR2 as gene chameleons with antagonistic duality : Preclinical, human translational, and mechanistic basis", Cancer Sci, 111, pp.3416~3425 (2020)
45. Qin, B., "DBC1 functions as a tumor suppressor by regulating p53 stability", Cell Rep, 10, pp.1324~1334 (2015)
46. Close, P., "DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation", Nature, 484, pp.386~389 (2012)
47. Huan, Y., "DBC1 promotes anoikis resistance of gastric cancer cells by regulating NF-kappaB activity", Oncol. Rep, 34, pp.843~849 (2015)
48. Ha, S. Y., "Expression of DBC1 is associated with poor prognosis in hepatitis virus-related hepatocellular carcinoma", Pathol. Res Pr, 212, pp.616~621 (2016)
49. Moon, S. J., "DBC1 promotes castration-resistant prostate cancer by positively regulating DNA binding and stability of AR-V7", Oncogene, 37, pp.1326~1339 (2018)
50. Wagle, S., "DBC1", CCAR2 is involved in the stabilization of androgen receptor and the progression of osteosarcoma, 2015, pp.5, 13144~
51. Yu, E. J., "Reciprocal roles of DBC1 and SIRT1 in regulating estrogen receptor alpha activity and co-activator synergy", Nucleic Acids Res, 39, pp.6932~6943 (2011)
52. Best, S. A., "CCAR2 Is Required for Proliferation and Tumor Maintenance in Human Squamous Cell Carcinoma", J. Invest Dermatol, 137, pp.506~512 (2017)
53. Akande, O. E., "DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination", Cell Rep, 26, pp.3323~3335 (2019)
54. Hu, J., "Targeting mutant p53 for cancer therapy : direct and indirect strate gies", J. Hematol. Oncol, 14, pp.157~ (2021)
55. Tang, Q., "Mutant p53 regulates Survivin to foster lung metastasis", Genes Dev, 35, pp.528~541 (2021)
56. Zhu, G., "Mutant p53 in Cancer Progression and Targeted Therapies", Front Oncol, 10, pp.595187~ (2020)
57. Rishi, A. K., "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437", J. Biol. Chem, 278, pp.33422~33435 (2003)
58. Rishi, A. K., "Cell cycle-and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor", J. Biol. Chem, 281, pp.13188~13198 (2006)
59. Puliyappadamba, V. T., "Antagonists of anaphase-promoting complex(APC)2-cell cycle and apoptosis regulatory protein(CARP)-1 interaction are novel regulators of cell growth and apoptosis", J. Biol. Chem, 286, pp.38000~38017 (2011)
60. Sekhar S. C., "A H2AX(-)CARP-1 Interaction Regulates Apoptosis Signaling Following DNA Damage", Cancers (Basel), 11 (2019)[DOI]
61. Li, G., "CCAR1 5’ UTR as a natural miRancer of miR-1254 overrides tamoxifen resistance", Cell Res, 26, pp.655~673 (2016)
62. Ou, C. Y., "Requirement of cell cycle and apoptosis regulator 1 for target gene activation by Wnt and beta-catenin and for anchorage-independent growth of human colon carcinoma cells", J. Biol. Chem, 284, pp.20629~20637 (2009)
63. Kim, J. H., "CCAR1, a key regulator of mediator complex recruitment to nuclear receptor transcription complexes", Mol. Cell, 31, pp.510~519 (2008)
64. Seo, W. Y., "CCAR1 promotes chromatin loading of androgen receptor(AR)transcription complex by stabilizing the association between AR and GATA2", Nucleic Acids Res, 41, pp.8526~8536 (2013)
65. Ou, C. Y., "Coregulator cell cycle and apoptosis regulator 1(CCAR1)positively regulates adipocyte differentiation through the glucocorticoid signaling pathway", J. Biol. Chem, 289, pp.17078~17086 (2014)
66. Oltean, S., "Hallmarks of alternative splicing in cancer", Oncogene, 33, pp.5311~5318 (2014)
67. Mannen, T., "Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines", Mol. Biol. Cell, 32, pp.ar33~ (2021)

관련 논문AI추천