자외선 조사 마우스에서 만성 피부손상에 대한 분죽(Phyllostachys nigra var. henenis Strapf)잎 추출물의 효과
Photoprotective Effect of Bamboo (Phyllostachys nigra var. henenis Strapf) Leaf Extract against Ultraviolet Radiation-induced Chronic Skin Damage in the Hairless Mouse
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To evaluate the ability of Bamboo (Phyllostachys nigra var. henenis Strapf) leaf extract(BL) to protect the skin from photodamage, the gross and microscopic changes in the skin of hairlessmice and BL-treated mice exposed chronically to ultraviolet (UV) were examined. The skin ofthe UV-irradiated mice showed characteristic signs of photoaging, such as deep wrinkles acrossthe back, increased epidermal thickeness, numerous cell infiltration, and many enlarged keratinizingcysts. BL-treated mice showed a significantly decreased wrinkling score and lack of proliferationof cysts. By the 22nd week, 88.9% (i.p. with saline) or 60.0% (topical administration withcream base) of the UV-irradiated mice developed at least one tumor. BL delayed tumor onsetsignificantly. BL (i.p.) was also effective in reducing the occurrence of UV radiation-induced skintumors and reduced the number of tumors per mouse. After 22 weeks of treatment, 37.5% (i.p.) ofthe mice treated with BL were tumor-free. Tumor multiplicity was reduced by 81.2% (i.p.) in theBL treated groups. It is noted that skin that is chronically exposed to UV is subject to photoagingand photocarcinogenesis and regular use of BL would prevent these photodamaging effects of UV.
Abstract
To evaluate the ability of Bamboo (Phyllostachys nigra var. henenis Strapf) leaf extract(BL) to protect the skin from photodamage, the gross and microscopic changes in the skin of hairlessmice and BL-treated mice exposed chronically to ultraviolet (UV) were examined. The skin ofthe UV-irradiated mice showed characteristic signs of photoaging, such as deep wrinkles acrossthe back, increased epidermal thickeness, numerous cell infiltration, and many enlarged keratinizingcysts. BL-treated mice showed a significantly decreased wrinkling score and lack of proliferationof cysts. By the 22nd week, 88.9% (i.p. with saline) or 60.0% (topical administration withcream base) of the UV-irradiated mice developed at least one tumor. BL delayed tumor onsetsignificantly. BL (i.p.) was also effective in reducing the occurrence of UV radiation-induced skintumors and reduced the number of tumors per mouse. After 22 weeks of treatment, 37.5% (i.p.) ofthe mice treated with BL were tumor-free. Tumor multiplicity was reduced by 81.2% (i.p.) in theBL treated groups. It is noted that skin that is chronically exposed to UV is subject to photoagingand photocarcinogenesis and regular use of BL would prevent these photodamaging effects of UV.
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