A New Approach to the Treatment of Metastatic Paraganglioma: Sorafenib
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Paragangliomas are relatively rare chromaffin cell tumors which may be cured throughresection. Patients with paragangliomas may develop metastatic diseases. There isno consensus regarding refractory chemotherapy for treatment of metastatic disease. In this report, we presented a case of a 43-year-old woman who was admitted to thehospital with a history of episodic headaches, diaphoresis, and weakness. Elevatedplasma catecholamine levels and a right paraaortic mass were observed on computedtomography. The mass was excised, and a diagnosis of paraganglioma was confirmed. After 20 months of follow-up, local recurrence and metastases were detected in thethorax, abdomen, and skeletal system. Plasma and urinary catecholamine levels werehigh. Chemotherapy was administered, and no improvement was observed. Therefore,following this palliative conventional chemotherapy, sorafenib was administered forthree months, and, finally, positron emission tomography showed that the patient’slesions had completely regressed.
Abstract
Paragangliomas are relatively rare chromaffin cell tumors which may be cured throughresection. Patients with paragangliomas may develop metastatic diseases. There isno consensus regarding refractory chemotherapy for treatment of metastatic disease. In this report, we presented a case of a 43-year-old woman who was admitted to thehospital with a history of episodic headaches, diaphoresis, and weakness. Elevatedplasma catecholamine levels and a right paraaortic mass were observed on computedtomography. The mass was excised, and a diagnosis of paraganglioma was confirmed. After 20 months of follow-up, local recurrence and metastases were detected in thethorax, abdomen, and skeletal system. Plasma and urinary catecholamine levels werehigh. Chemotherapy was administered, and no improvement was observed. Therefore,following this palliative conventional chemotherapy, sorafenib was administered forthree months, and, finally, positron emission tomography showed that the patient’slesions had completely regressed.
참고문헌 (13)
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