Research Progress of Central and Peripheral Corticotropin-Releasing Hormone in Irritable Bowel Syndrome with Comorbid Dysthymic Disorders
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Irritable bowel syndrome (IBS) is considered a stress disorder characterized by psychological and gastrointestinal dysfunction. IBS patients not only suffer from intestinal symptoms such as abdominal pain, diarrhea, or constipation but also, experience dysthymic disorders such as anxiety and depression. Studies have found that corticotropin-releasing hormone plays a key role in IBS with comorbid dysthymic disorders. Next, we will summarize the effects of corticotropinreleasing hormone from the central nervous system and periphery on IBS with comorbid dysthymic disorders and relevant treatments based on published literatures in recent years.
Abstract
Irritable bowel syndrome (IBS) is considered a stress disorder characterized by psychological and gastrointestinal dysfunction. IBS patients not only suffer from intestinal symptoms such as abdominal pain, diarrhea, or constipation but also, experience dysthymic disorders such as anxiety and depression. Studies have found that corticotropin-releasing hormone plays a key role in IBS with comorbid dysthymic disorders. Next, we will summarize the effects of corticotropinreleasing hormone from the central nervous system and periphery on IBS with comorbid dysthymic disorders and relevant treatments based on published literatures in recent years.
참고문헌 (133)
- Camilleri M, "Management options for irritable bowel syndrome", Mayo Clin Proc, 93, pp.1858~1872 (2018)
- Radovanovic-Dinic B, "Irritable bowel syndrome : from etiopathogenesis to therapy", Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 162, pp.1~9 (2018)
- Li HY, "Meta analysis of acupuncture and moxibustion for anxiety and depression in irritable bowel syndrome", Zhen Ci Yan Jiu, 47, pp.821~829 (2022)
- Magdy R, "The potential impact of nutritional intake on symptoms severity in patients with comorbid migraine and irritable bowel syndrome", BMC Neurol, 22, pp.199~ (2022)
- Ohlsson B, "Extraintestinal manifestations in irritable bowel syndrome : a systematic review", Therap Adv Gastroenterol, 15, pp.17562848221114558~ (2022)
- Khan EH, "Psychiatric morbidity in irritable bowel syndrome", Mymensingh Med J, 31, pp.458~465 (2022)
- Tache Y, "Brain and gut CRF signaling : biological actions and role in the gastrointestinal tract", Curr Mol Pharmacol, 11, pp.51~71 (2018)
- Labanski A, "Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases : a transdisciplinary challenge", Psychoneuroendocrinology, 111, pp.104501~ (2020)
- Nikolova VL, "The prevalence and incidence of irritable bowel syndrome and inflammatory bowel disease in depression and bipolar disorder : a systematic review and meta-analysis", Psychosom Med, 84, pp.313~324 (2022)
- Waters RP, "Evidence for the role of corticotropin-releasing factor in major depressive disorder", Neurosci Biobehav Rev, 58, pp.63~78 (2015)
- Meerveld BG, "Mechanisms of stress-induced visceral pain", J Neurogastroenterol Motil, 24, pp.7~18 (2018)
- Vale W, "Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin", Science, 213, pp.1394~1397 (1981)
- Zhu JJ, "Roles of CRHR1 and CRHR2 in visceral hypersensitivity of irritable bowel syndrome", Chin J Integr Trad West Med Dig, 25, pp.73~77 (2017)
- Su SS, "Research progress of corticotropin-releasing hormone family", Jilin Med J, 38, pp.565~567 (2017)
- Ma S, "Molecular basis for hormone recognition and activation of corticotropin-releasing factor receptors", Mol Cell, 77, pp.669~680 (2020)
- Vasconcelos M, "Corticotropin-releasing factor receptor signaling and modulation : implications for stress response and resilience", Trends Psychiatry Psychother, 42, pp.195~206 (2020)
- Ligon CO, "Peripheral guanylate cyclase-C modulation of corticolimbic activation and corticotropin-releasing factor signaling in a rat model of stress-induced colonic hypersensitivity", Neurogastroenterol Motil, 33, pp.e14076~ (2021)
- Bülbül M, "Enteric apelin enhances the stress-induced stimulation of colonic motor functions", Stress, 23, pp.201~212 (2020)
- Larauche M, "Cortagine, a CRF1agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways", Am J Physiol Gastrointest Liver Physiol, 297, pp.G215~G227 (2009)
- Million M, "CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1", 2 phosphorylation in rats, 2006, pp.55, 172~181
- Jiang Y, "Role of corticotropin releasing factor in the neuroimmune mechanisms of depression : examination of current pharmaceutical and herbal therapies", Front Cell Neurosci, 13, pp.290~ (2019)
- Song JZ, "Inflammatory reaction in irritable bowel syndrome with depressive symptoms", Ph.D., pp.2017
- Wang XS, "The role of central CRF system in stress-induced gastric motility changes", J Shandong Norm Univ(Nat Sci), 36, pp.311~315 (2021)
- Chen XF, "Aberrant intraregional brain activity and functional connectivity in patients with diarrhea-predominant irritable bowel syndrome", Front Neurosci, 15, pp.721822~ (2021)
- Inda C, "Endocrinology and the brain : corticotropin-releasing hormone signaling", Endocr Connect, 6, pp.R99~R120 (2017)
- Vandael D, "Corticotropin-releasing factor induces functional and structural synaptic remodelling in acute stress", Transl Psychiatry, 11, pp.378~ (2021)
- Schindler S, "Hypothalamus enlargement in mood disorders", Acta Psychiatr Scand, 139, pp.56~67 (2019)
- Chao G, "Cytokines in the colon, central nervous system and serum of irritable bowel syndrome rats", Eur J Med Res, 26, pp.7~ (2021)
- Zhang G, "Activation of corticotropinreleasing factor neurons and microglia in paraventricular nucleus precipitates visceral hypersensitivity induced by colorectal distension in rats", Brain Behav Immun, 55, pp.93~104 (2016)
- Song Y, "Disinhibition of PVN-projecting GABAergic neurons in AV region in BNST participates in visceral hypersensitivity in rats", Psychoneuroendocrinology, 117, pp.104690~ (2020)
- Huang ST, "BNSTAV GABA-PVNCRF circuit regulates visceral hypersensitivity induced by maternal separation in Vgat-Cre mice", Front Pharmacol, 12, pp.615202~ (2021)
- Chen YN, "Research progress on affective disorder based on corticotropin-releasing hormone receptor 1", J Neurosci Ment Health, 18, pp.190~194 (2018)
- Daviu N, "Neurobiological links between stress and anxiety", Neurobiol Stress, 11, pp.100191~ (2019)
- Qin XY, "PSD-93 up-regulates the synaptic activity of corticotropin-releasing hormone neurons in the paraventricular nucleus in depression", Acta Neuropathol, 142, pp.1045~1064 (2021)
- Zhang R, "Loss of hypothalamic corticotropin-releasing hormone markedly reduces anxiety behaviors in mice", Mol Psychiatry, 22, pp.733~744 (2017)
- Babaev O, "Inhibition in the amygdala anxiety circuitry", Exp Mol Med, 50, pp.1~16 (2018)
- Nisticò V, "Functional neuroimaging in irritable bowel syndrome : a systematic review highlights common brain alterations with functional movement disorders", J Neurogastroenterol Motil, 28, pp.185~203 (2022)
- Neugebauer V, "Amygdala, neuropeptides, and chronic pain-related affective behaviors", Neuropharmacology, 170, pp.108052~ (2020)
- Louwies T, "Stressinduced visceral pain in female rats is associated with epigenetic remodeling in the central nucleus of the amygdala", Neurobiol Stress, 15, pp.100386~ (2021)
- Louwies T, "Chronic stress increases DNA methylation of the GR promoter in the central nucleus of the amygdala of female rats", Neurogastroenterol Motil, 34, pp.e14377~ (2022)
- Tafet GE, "Pharmacological treatment of anxiety disorders : the role of the HPA axis", Front Psychiatry, 11, pp.443~ (2020)
- Ventura-Silva AP, "Amygdalar corticotropin-releasing factor mediates stressinduced anxiety", Brain Res, 1729, pp.146622~ (2020)
- Guo J, "Explore the possible mechanism of acupuncture relieving visceral hypersensitivity based on epigenetics", Mod Tradit Chin Med World Sci Technol, 22, pp.3418~3423 (2020)
- Pomrenze MB, "A corticotropin releasing factor network in the extended amygdala for anxiety", J Neurosci, 39, pp.1030~1043 (2019)
- Chen L, "Activation of CRF", CRFR1 signaling in the basolateral nucleus of the amygdala contributes to chronic forced swim-induced depressive-like behaviors in rats, 2018, pp.338, 134~142
- Wang Y, "Exposure of male mice to perfluorooctanoic acid induces anxiety-like behaviors by increasing corticotropin-releasing factor in the basolateral amygdala complex", Chemosphere, 287(Pt 3), pp.132170~ (2022)
- Morris LS, "The role of the locus coeruleus in the generation of pathological anxiety", Brain Neurosci Adv, 4, pp.2398212820930321~ (2020)
- Wang X, "Activation of corticotropinreleasing hormone system in the locus ceruleus induces the visceral sensitivity of irritable bowel syndrome rats", Chin J Dig, (12), pp.40~44 (2020)
- Borodovitsyna O, "Anatomically and functionally distinct locus coeruleus efferents mediate opposing effects on anxiety-like behavior", Neurobiol Stress, 13, pp.100284~ (2020)
- Borodovitsyna O, "Age-and sex-dependent changes in locus coeruleus physiology and anxiety-like behavior following acute stressor exposure", Front Behav Neurosci, 16, pp.808590~ (2022)
- McCall JG, "CRH engagement of the locus coeruleus noradrenergic system mediates stressinduced anxiety", Neuron, 87, pp.605~620 (2015)
- Hupalo S, "Corticotropin-releasing factor(CRF)circuit modulation of cognition and motivation", Neurosci Biobehav Rev, 103, pp.50~59 (2019)
- Ren J, "Anatomically defined and functionally distinct dorsal raphe serotonin sub-systems", Cell, 175, pp.472~487 (2018)
- Haleem DJ, "Targeting serotonin1A receptors for treating chronic pain and depression", Curr Neuropharmacol, 17, pp.1098~1108 (2019)
- Huang KW, "Molecular and anatomical organization of the dorsal raphe nucleus", Elife, 8, pp.e46464~ (2019)
- Jiang SM, "Clinical research on progress of irritable bowel syndrome based on brain-gut axis", World Chin Med, 15, pp.3351~3354 (2020)
- Li C, "CRF-5-HT interactions in the dorsal raphe nucleus and motivation for stress-induced opioid reinstatement", Psychopharmacology(Berl), 238, pp.29~40 (2021)
- Pernar L, "Selective activation of corticotropin-releasing factor-2 receptors on neurochemically identified neurons in the rat dorsal raphe nucleus reveals dual actions", J Neurosci, 24, pp.1305~1311 (2004)
- Donner NC, "Serotonergic systems in the balance : CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis", Psychoneuroendocrinology, 63, pp.178~190 (2016)
- Waselus M, "Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus", Biol Psychiatry, 66, pp.76~83 (2009)
- Zhang L, "Role of CRF on 5-HT signaling pathway and visceral hypersensitivity in rats", Chin J Gastroenterol, 16, pp.534~538 (2011)
- Cao DY, "Differential activation of colonic afferents and dorsal horn neurons underlie stress-induced and comorbid visceral hypersensitivity in female rats", J Pain, 22, pp.1283~1293 (2021)
- Louwies T, "Targeting epigenetic mechanisms for chronic visceral pain : a valid approach for the development of novel therapeutics", Neurogastroenterol Motil, 31, pp.e13500~ (2019)
- Lyubashina OA, "Supraspinal mechanisms of intestinal hypersensitivity", Cell Mol Neurobiol, 42, pp.389~417 (2022)
- Nakamori H, "Medullary raphe nuclei activate the lumbosacral defecation center through the descending serotonergic pathway to regulate colorectal motility in rats", Am J Physiol Gastrointest Liver Physiol, 314, pp.G341~G348 (2018)
- Xu GZ, "Valproate reverses stress-induced somatic hyperalgesia and visceral hypersensitivity by up-regulating spinal 5-HT2C receptor expression in female rats", Neuropharmacology, 165, pp.107926~ (2020)
- El-Ayache N, "5-HT3 receptor signaling in serotonin transporter-knockout rats : a female sex-specific animal model of visceral hypersensitivity", Am J Physiol Gastrointest Liver Physiol, 316, pp.G132~G143 (2019)
- Liu HR, "Effects of electroacupuncture on corticotropin-releasing hormone in rats with chronic visceral hypersensitivity", World J Gastroenterol, 21, pp.7181~7190 (2015)
- Mousa SA, "Functional and anatomical characterization of corticotropin-releasing factor receptor subtypes of the rat spinal cord involved in somatic pain relief", Mol Neurobiol, 58, pp.5459~5472 (2021)
- Nijsen M, "Divergent role for CRF1 and CRF2 receptors in the modulation of visceral pain", Neurogastroenterol Motil, 17, pp.423~432 (2005)
- Hummel M, "Pain is a salient"stressor"that is mediated by corticotropin-releasing factor-1receptors", Neuropharmacology, 59, pp.160~166 (2010)
- Sukhareva EV, "The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response", Vavilovskii Zhurnal Genet Selektsii, 25, pp.216~223 (2021)
- Filaretova LP, "Peripheral corticotropin-releasing hormone may protect the gastric mucosa against indomethacin-induced injury through involvement of glucocorticoids", J Physiol Pharmacol, 72, pp.711~720 (2021)
- Li T, "Chronic stress impairs male spermatogenesis function and Nectin-3 protein expression in the testis", Physiol Res, 69, pp.297~306 (2020)
- Takefuji M, "Corticotropin-releasing hormone family and their receptors in the cardiovascular system", Circ J, 83, pp.261~266 (2019)
- Li H, "Activation of CRF2 receptor increases gastric vagal afferent mechanosensitivity", J Neurophysiol, 122, pp.2636~2642 (2019)
- Larauche M, "Corticotropin releasing factor signaling in colon and ileum : regulation by stress and pathophysiological implications", J Physiol Pharmacol, 60(Suppl 7(Suppl 7)), pp.33~46 (2009)
- Li B, "Inhibition of corticotropin-releasing hormone receptor 1 and activation of receptor 2 protect against colonic injury and promote epithelium repair", Sci Rep, 7, pp.46616~ (2017)
- Chatoo M, "Involvement of corticotropin-releasing factor and receptors in immune cells in irritable bowel syndrome", Front Endocrinol(Lausanne), 9, pp.21~ (2018)
- D'Costa S, "Mast cell corticotropin-releasing factor subtype 2 suppresses mast cell degranulation and limits the severity of anaphylaxis and stressinduced intestinal permeability", J Allergy Clin Immunol, 143, pp.1865~1877 (2019)
- Cheng L, "The role of intestinal mast cell infiltration in irritable bowel syndrome", J Dig Dis, 22, pp.143~151 (2021)
- Singh M, "The relationship between mucosal inflammatory cells, specific symptoms, and psychological functioning in youth with irritable bowel syndrome", Sci Rep, 10, pp.11988~ (2020)
- Bashashati M, "Colonic immune cells in irritable bowel syndrome : a systematic review and meta-analysis", Neurogastroenterol Motil, 30, pp.e13192~ (2018)
- Uranga JA, "Mast cell regulation and irritable bowel syndrome : effects of food components with potential nutraceutical use", Molecules, 25, pp.4314~ (2020)
- Huang H, "The mechanism of CRF modulating mast cells in the pathogenesis of irritable bowel syndrome", Ph.D., pp.2017
- Keszthelyi D, "Serotonergic reinforcement of intestinal barrier function is impaired in irritable bowel syndrome", Aliment Pharmacol Ther, 40, pp.392~402 (2014)
- Costantini TW, "Phosphodiesterase inhibition attenuates alterations to the tight junction proteins occludin and ZO-1 in immunostimulated Caco-2 intestinal monolayers", Life Sci, 84, pp.18~22 (2009)
- Overman EL, "CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α", PLoS One, 7, pp.e39935~ (2012)
- Hasler WL, "Mast cell mediation of visceral sensation and permeability in irritable bowel syndrome", Neurogastroenterol Motil, 34, pp.e14339~ (2022)
- Chen Y, "Electroacupuncture regulates disorders of gut-brain interaction by decreasing corticotropin-releasing factor in a rat model of IBS", Gastroenterol Res Pract, 2019, pp.1759842~ (2019)
- Ayyadurai S, "Frontline science : corticotropin-releasing factor receptor subtype 1 is a critical modulator of mast cell degranulation and stress-induced pathophysiology", J Leukoc Biol, 102, pp.1299~1312 (2017)
- Larauche M, "Novel insights in the role of peripheral corticotropin-releasing factor and mast cells in stressinduced visceral hypersensitivity", Neurogastroenterol Motil, 24, pp.201~205 (2012)
- Vanuytsel T, "Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism", Gut, 63, pp.1293~1299 (2014)
- Guilarte M, "Peripheral corticotropin-releasing factor triggers jejunal mast cell activation and abdominal pain in patients with diarrheapredominant irritable bowel syndrome", Am J Gastroenterol, 115, pp.2047~2059 (2020)
- Jin DC, "Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome", World J Gastroenterol, 22, pp.8137~8148 (2016)
- Qin HY, "Enterochromaffin cell hyperplasia in the gut : factors, mechanism and therapeutic clues", Life Sci, 239, pp.116886~ (2019)
- Fu R, "Expression and clinical significance of 5-HT and 5-HT3R in the intestinal mucosa of patient with diarrhea-type irritable bowel syndrome", Exp Ther Med, 17, pp.3077~3082 (2019)
- Stasi C, "Serotonin receptors and their role in the pathophysiology and therapy of irritable bowel syndrome", Tech Coloproctol, 18, pp.613~621 (2014)
- Wu SV, "Activation of type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells : an enterochromaffin cell model", Endocrinology, 152, pp.126~137 (2011)
- Erspamer V, "Occurrence and distribution of 5-hydroxytryptamine(enteramine)in the living organism", Z Vitam Horm Fermentforsch, 9, pp.74~96 (1957)
- Kodani M, "Association between gastrointestinal motility and macrophage", mast cell distribution in mice during the healing stage after DSS‑induced colitis, 2018, pp.17, 8167~8172
- Nozu T, "Altered colonic sensory and barrier functions by CRF : roles of TLR4 and IL-1", J Endocrinol, 239, pp.241~252 (2018)
- Song JZ, "Corticotropinreleasing factor and Toll-like receptor gene expression is associated with low-grade inflammation in irritable bowel syndrome patients with depression", Gastroenterol Res Pract, 2016, pp.7394924~ (2016)
- Nozu T, "Pathophysiological commonality between irritable bowel syndrome and metabolic syndrome : role of corticotropin-releasing factor-Toll-like receptor 4-proinflammatory cytokine signaling", J Neurogastroenterol Motil, 28, pp.173~184 (2022)
- Wallon C, "Eosinophils express muscarinic receptors and corticotropin-releasing factor to disrupt the mucosal barrier in ulcerative colitis", Gastroenterology, 140, pp.1597~1607 (2011)
- Zheng PY, "Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine", Gut, 58, pp.1473~1479 (2009)
- Katinios G, "Increased colonic epithelial permeability and mucosal eosinophilia in ulcerative colitis in remission compared with irritable bowel syndrome and health", Inflamm Bowel Dis, 26, pp.974~984 (2020)
- Hassanin TM, "Colonic mucosal eosinophilia and immunohistochemical expression of COX-2 and NF-kB in patients with irritable bowel syndrome", Eur J Gastroenterol Hepatol, 34, pp.512~517 (2022)
- Salvo-Romero E, "Overexpression of corticotropin-releasing factor in intestinal mucosal eosinophils is associated with clinical severity in Diarrhea-Predominant Irritable Bowel Syndrome", Sci Rep, 10, pp.20706~ (2020)
- Li S, "Changes in enteric neurons of small intestine in a rat model of irritable bowel syndrome with diarrhea", J Neurogastroenterol Motil, 22, pp.310~320 (2016)
- Traini C, "Changes of excitatory and inhibitory neurotransmitters in the colon of rats underwent to the wrap partial restraint stress", Neurogastroenterol Motil, 28, pp.1172~1185 (2016)
- Liu S, "Expression of type 1 corticotropin-releasing factor receptor in the guinea pig enteric nervous system", J Comp Neurol, 481, pp.284~298 (2005)
- Buckley MM, "Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome", J Physiol, 592, pp.5235~5250 (2014)
- Lv Y, "Corticotropinreleasing factor receptor 1(CRF-R1)antagonists : promising agents to prevent visceral hypersensitivity in irritable bowel syndrome", Peptides, 147, pp.170705~ (2022)
- Zobel AW, "Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression : the first 20 patients treated", J Psychiatr Res, 34, pp.171~181 (2000)
- Künzel HE, "Treatment with a CRH-1-receptor antagonist(R121919)does not affect weight or plasma leptin concentration in patients with major depression", J Psychiatr Res, 39, pp.173~177 (2005)
- Hubbard CS, "Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain", J Neurosci, 31, pp.12491~12500 (2011)
- Saito K, "Corticotropin-releasing hormone receptor 1 antagonist blocks brain-gut activation induced by colonic distention in rats", Gastroenterology, 129, pp.1533~1543 (2005)
- Pagán-Busigó JE, "Beyond depression and anxiety; a systematic review about the role of corticotropin-releasing hormone antagonists in diseases of the pelvic and abdominal organs", PLoS One, 17, pp.e0264909~ (2022)
- Turcu AF, "Single-dose study of a corticotropin-releasing factor receptor-1 antagonist in women with 21-hydroxylase deficiency", J Clin Endocrinol Metab, 101, pp.1174~1180 (2016)
- Menke A, "Is the HPA axis as target for depression outdated, or is there a new hope?", Front Psychiatry, 10, pp.101~ (2019)
- Mukai Y, "Identification of substances which regulate activity of corticotropin-releasing factor-producing neurons in the paraventricular nucleus of the hypothalamus", Sci Rep, 10, pp.13639~ (2020)
- Sunstrum JK, "Heterosynaptic modulation in the paraventricular nucleus of the hypothalamus", Neuropharmacology, 154, pp.87~95 (2019)
- Di T, "Dopaminergic afferents from midbrain to dorsolateral bed nucleus of stria terminalis inhibit release and expression of corticotropin-releasing hormone in paraventricular nucleus", J Neurochem, 154, pp.218~234 (2020)
- Zhao TK, "Effects of amitriptyline on ACTH releasing factor expression in colon and hypothalamus of rats with irritable bowel syndrome", Chin J Gerontol, 37, pp.3142~3144 (2017)
- Orock A, "Environmental enrichment prevents stress-induced epigenetic changes in the expression of glucocorticoid receptor and corticotrophin releasing hormone in the central nucleus of the amygdala to inhibit visceral hypersensitivity", Exp Neurol, 345, pp.113841~ (2021)
- Zhang HF, "Effect of heat-sensitive moxibustion on CRH and CRF in hypothalamus and GR in adrenal gland of IBS rats", Liaoning Journal of Traditional Chinese Medicine, 45, pp.1076~1079 (2018)
- Wang Y, "Effect of Zi Wu Liu Zhu needling method on the central regulation of HPA axis in psychological stress rat models", Shanghai J Acupunct Moxibustion, 39, pp.75~83 (2020)
- Yang M, "Effect of acupuncture combined with medicine on imbalance of brain-gut axis in rats with irritable bowel syndrome", Chin J Pathophysiol, 37, pp.2251~2257 (2021)
- He F, "Effect of electroacupuncture on the activity of corticotrophin-releasing hormone neurons in the hypothalamus and amygdala in rats exposed to restraint water-immersion stress", Acupunct Med, 36, pp.394~400 (2018)
- Li JT, "Moxibustion improved gastric ulcer by reducing contents of corticotrophin-releasing hormone and adrenocorticotropic hormone in serum and hypothalamus-pituitary tissues in rats with stress-induced gastric ulcer", Zhen Ci Yan Jiu, 44, pp.347~351 (2019)
- Seo SY, "Acupuncture alleviates anxiety and 22-kHz ultrasonic vocalizations in rats subjected to repeated alcohol administration by modulating the brain-derived neurotrophic factor", corticotropin-releasing hormone signaling pathway, 2021, pp.22, 4037~
- Zhao YX, "Electroacupuncture ameliorates corticotrophin-releasing factor-induced jejunal dysmotility in a rat model of stress", Acupunct Med, 39, pp.135~145 (2021)
