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Effect of Human or Mouse IL-7 on the Homeostasis of Porcine T Lymphocytes

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Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.

Abstract

Due to the inconsistent fluctuation of blood supply for transfusion, much attention has been paid to the development of artificial blood using other animals. Although mini-pigs are candidate animals, contamination of mini-pig T cells in artificial blood may cause a major safety concern. Therefore, it is important to analyze the cross-reactivity of IL-7, the major survival factor for T lymphocytes, between human, mouse, and mini-pig. Thus, we compared the protein sequences of IL-7 and found that porcine IL-7 was evolutionarily different from human IL-7. We also observed that when porcine T cells were cultured with either human or mouse IL-7, these cells did not increase the survival or proliferation compared to negative controls. These results suggest that porcine T cells do not recognize human or mouse IL-7 as their survival factor.

참고문헌 (38)

  1. Park CG, "Current status and future perspectives of xenotransplantation", J Korean Soc Transplant, 23, pp.203~213 (2009)
  2. 김재환, "수혈요법의 최신지견", 대한의사협회지, 56(6), pp.496~503 (2013), 대한의사협회
  3. Kresie L, "Artificial blood : an update on current red cell and platelet substitutes", Proc Bayl Univ Med Cent, 14, pp.158~116 (2001)
  4. Cooper DK, "A brief history of cross-species organ transplantation", Proc Bayl Univ Med Cent, 25, pp.49~57 (2012)
  5. Moradi S, "Artificial blood substitutes : first steps on the long route to clinical utility", Clin Med Insights Blood Disord, 9, pp.33~41 (2016)
  6. Wakelin D, "Genetic control of immunity to Trichinella spiralis. Donor bone marrow cells determine responses to infection in mouse radiation chimaeras", Immunology, 43, pp.787~792 (1981)
  7. Wiener LS, "Hematopoietic stem cell donation in children : a review of the sibling donor experience", J Psychosoc Oncol, 25, pp.45~66 (2007)
  8. Zhao E, "Bone marrow and the control of immunity", Cell Mol Immunol, 9, pp.11~19 (2012)
  9. Hara H, "Abstract #657. Genetically-engineered pigs as a potential source of red blood cells for clinical blood transfusion", Am J Transplant, 9, pp.381~ (2009)
  10. Taylor MJ, "Optimizing red blood cell transfusion therapy in the 21st century : the power of data analysis for past understanding and future guidance", Transfusion, 53, pp.470~475 (2013)
  11. Soo-Young Yum, "Transgenesis for pig models", Journal of Veterinary Science, 17(3), pp.261~268 (2016), 대한수의학회[DOI]
  12. Dasararaju R, "Adverse effects of transfusion", Cancer Contr, 22, pp.16~25 (2015)
  13. Markey KA, "The biology of graft-versus-host disease : experimental systems instructing clinical practice", Blood, 124, pp.354~362 (2014)
  14. Burrows SR, "An alloresponse in humans is dominated by cytotoxic T lymphocytes(CTL)cross-reactive with a single Epstein-Barr virus CTL epitope : implications for graft-versus-host disease", J Exp Med, 179, pp.1155~1161 (1994)
  15. Okoye IS, "CD4+ T helper 2 cells--microbial triggers, differentiation requirements and effector functions", Immunology, 134, pp.368~377 (2011)
  16. Mosmann TR, "Cytokines, differentiation and functions of subsets of CD4 and CD8 T cells", Behring Inst Mitt, 1995, pp.1~6 (1995)
  17. Zhu J, "Differentiation of effector CD4 T cell populations(*)", Annu Rev Immunol, 28, pp.445~489 (2010)
  18. Shlomchik WD, "Prevention of graft versus host disease by inactivation of host antigen-presenting cells", Science, 285, pp.412~415 (1999)
  19. Hauschild J, "Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases", Proc Natl Acad Sci U S A, 108, pp.12013~12017 (2011)
  20. Tan JT, "Interleukin(IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells", J Exp Med, 195, pp.1523~1532 (2002)
  21. Tan JT, "IL-7 is critical for homeostatic proliferation and survival of naive T cells", Proc Natl Acad Sci U S A, 98, pp.8732~8737 (2001)
  22. Rathmell JC, "IL-7 enhances the survival and maintains the size of naive T cells", J Immunol, 167, pp.6869~6876 (2001)
  23. Hong C, "Intrathymic IL-7 : the where, when, and why of IL-7 signaling during T cell development", Semin Immunol, 24, pp.151~158 (2012)
  24. Hare KJ, "An essential role for the IL-7 receptor during intrathymic expansion of the positively selected neonatal T cell repertoire", J Immunol, 165, pp.2410~2414 (2000)
  25. Offner F, "The role of interleukin-7 in early T-cell development", Leuk Lymphoma, 30, pp.87~99 (1998)
  26. Krenger W, "Thymic T-cell development in allogeneic stem cell transplantation", Blood, 117, pp.6768~6776 (2011)
  27. Ma D, "Regulatory mechanisms of thymus and T cell development", Dev Comp Immunol, 39, pp.91~102 (2013)
  28. Kieper WC, "Overexpression of interleukin(IL)-7 leads to IL-15-independent generation of memory phenotype CD8+ T cells", J Exp Med, 195, pp.1533~1539 (2002)
  29. Saitou N, "The neighbor-joining method : a new method for reconstructing phylogenetic trees", Mol Biol Evol, 4, pp.406~425 (1987)
  30. Kaur G, "Evolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes", Sci Rep, 8, pp.6196~ (2018)
  31. Kumar S, "MEGA7 : molecular evolutionary genetics analysis version 7. 0 for bigger datasets", Mol Biol Evol, 33, pp.1870~1874 (2016)
  32. Mendoza A, "Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells", Nature, 546, pp.158~161 (2017)
  33. Tanabe T, "Role of intrinsic(graft)versus extrinsic(host)factors in the growth of transplanted organs following allogeneic and xenogeneic transplantation", Am J Transplant, 17, pp.1778~1790 (2017)
  34. Fry TJ, "Interleukin-7 : from bench to clinic", Blood, 99, pp.3892~3904 (2002)
  35. Roy A, "I-TASSER : a unified platform for automated protein structure and function prediction", Nat Protoc, 5, pp.725~738 (2010)
  36. Barata JT, "Molecular and functional evidence for activity of murine IL-7 on human lymphocytes", Exp Hematol, 34, pp.1133~1142 (2006)
  37. Francois B, "Interleukin-7 restores lymphocytes in septic shock : the iris-7 randomized clinical trial", JCI Insight, 3, pp.e98960~ (2018)
  38. van Lent AU, "IL-7 enhances thymic human T cell development in"human immune system"Rag2-", -IL2Rgammac-, J Immunol, pp.2009, 183[DOI]

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