Preischemic Treadmill Exercise Ameliorates Memory Impairment and Microvasculature Damage in Rat Model of Chronic Cerebral Hypoperfusion
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Purpose: Silent information regulator 1 (SIRT1) in the brain is essential for maintaining cellular homeostasis and plays a neuroprotective role in cerebral ischemia and neurodegenerative disorders. The effect of preischemic treadmill exercise on chronic cerebral hypoperfusion (CCH)-induced spatial learning memory impairment, microvascular injury, and blood-brain barrier (BBB) disruption in relation with SIRT1 expression was evaluated. Methods: Prior to bilateral common carotid artery occlusion (BCCAO) surgery, the rats in the exercise groups performed low-intensity treadmill running for 30 minutes once daily during 8 weeks. BCCAO surgery was performed on male Wistar rats at 12 weeks of age. Spatial learning memory was measured using the Morris water maze test. Neuronal nuclear antigen, SIRT1, and rat endothelial cells antigen 1 were determined by immunohistochemistry and platelet-derived growth factor receptor beta was determined by immunofluorescence. Results: Preischemic treadmill exercise ameliorated spatial learning memory impairment and enhanced SIRT1 expression in the BCCAO rats. Preischemic treadmill exercise ameliorated BCCAO-induced damage to microvasculature and pericytes that make up the BBB. The effect of preischemic treadmill exercise was lost with sirtinol treatment. Conclusions: These results can apply treadmill exercise prior to cerebral ischemia as a rational preventive and therapeutic intervention strategy to improve cognitive dysfunction in CCH patients.
Abstract
Purpose: Silent information regulator 1 (SIRT1) in the brain is essential for maintaining cellular homeostasis and plays a neuroprotective role in cerebral ischemia and neurodegenerative disorders. The effect of preischemic treadmill exercise on chronic cerebral hypoperfusion (CCH)-induced spatial learning memory impairment, microvascular injury, and blood-brain barrier (BBB) disruption in relation with SIRT1 expression was evaluated. Methods: Prior to bilateral common carotid artery occlusion (BCCAO) surgery, the rats in the exercise groups performed low-intensity treadmill running for 30 minutes once daily during 8 weeks. BCCAO surgery was performed on male Wistar rats at 12 weeks of age. Spatial learning memory was measured using the Morris water maze test. Neuronal nuclear antigen, SIRT1, and rat endothelial cells antigen 1 were determined by immunohistochemistry and platelet-derived growth factor receptor beta was determined by immunofluorescence. Results: Preischemic treadmill exercise ameliorated spatial learning memory impairment and enhanced SIRT1 expression in the BCCAO rats. Preischemic treadmill exercise ameliorated BCCAO-induced damage to microvasculature and pericytes that make up the BBB. The effect of preischemic treadmill exercise was lost with sirtinol treatment. Conclusions: These results can apply treadmill exercise prior to cerebral ischemia as a rational preventive and therapeutic intervention strategy to improve cognitive dysfunction in CCH patients.
참고문헌 (31)
- Román GC, "Vascular dementia may be the most common form of dementia in the elderly", J Neurol Sci (2002)
- Venkat P, "Models and mechanisms of vascular dementia", Exp Neurol (2015)
- Cai ZY, "Minocycline attenuates cognitive impairment and restrains oxidative stress in the hippocampus of rats with chronic cerebral hypoperfusion", Neurosci Bull, 24, pp.305~313 (2008)
- Lee JM, "NXP031 improves cognitive impairment in a chronic cerebral hypoperfusion-induced vascular dementia rat model through nrf2 signaling", Int J Mol Sci, 22, pp.6285~ (2021)
- Sá-Pereira I, "Neurovascular unit : a focus on pericytes", Mol Neurobiol, 45, pp.327~347 (2012)
- Dingezweni S, "The blood–brain barrier", S Afr J Anaesth Analg, 26, pp.S32~4 (2020)
- Brown LS, "Pericytes and neurovascular function in the healthy and diseased brain", Front Cell Neurosci, 13, pp.282~ (2019)
- Zhang W, "The blood brain barrier in cerebral ischemic injury-Disruption and repair", Brain Hemorrhages, 1, pp.34~53 (2020)
- Ferrara N, "Exercise training promotes SIRT1 activity in aged rats", Rejuvenation Res, 11, pp.139~150 (2008)
- Xu J, "Brain SIRT1 mediates metabolic homeostasis and neuroprotection", Front Endocrinol(Lausanne), 9, pp.702~ (2018)
- 홍민하, "Treadmill Exercise Improves Motor Function and Short-term Memory by Enhancing Synaptic Plasticity and Neurogenesis in Photothrombotic Stroke Mice", International Neurourology Journal, 24, pp.28~38 (2020), 대한배뇨장애요실금학회[DOI]
- Małkiewicz MA, "Blood-brain barrier permeability and physical exercise", J Neuroinflammation, 16, pp.15~ (2019)
- 이재민, "Preischemic treadmill exercise improves short-term memory by inhibiting hypoperfusion-induced disruption of blood-brain barrier after bilateral common carotid arteries occlusion", Journal of exercise rehabilitation, 15(3), pp.370~376 (2019), 한국운동재활학회[DOI]
- 서대윤, "Exercise and Neuroinflammation in Health and Disease", International Neurourology Journal, 23, pp.82~92 (2019), 대한배뇨장애요실금학회[DOI]
- Jing Z, "Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment", J Cereb Blood Flow Metab, 35, pp.1249~1259 (2015)
- 고영준, "Treadmill exercise in obese maternal rats during pregnancy improves spatial memory through activation of phosphatidylinositol 3-kinase pathway in the hippocampus of rat pups", Journal of exercise rehabilitation, 16(6), pp.483~488 (2020), 한국운동재활학회[DOI]
- 박혜상, "Swimming exercise ameliorates mood disorder and memory impairment by enhancing neurogenesis, serotonin expression, and inhibiting apoptosis in social isolation rats during adolescence", Journal of exercise rehabilitation, 16(2), pp.132~140 (2020), 한국운동재활학회[DOI]
- 이수신, "Treadmill exercise ameliorates memory impairment through ERK-Akt-CREB-BDNF signaling pathway in cerebral ischemia gerbils", Journal of exercise rehabilitation, 16(1), pp.49~57 (2020), 한국운동재활학회[DOI]
- Xiong Z, "Dl-3-n-butylphthalide treatment enhances hemodynamics and ameliorates memory deficits in rats with chronic cerebral hypoperfusion", Front Aging Neurosci, 9, pp.238~ (2017)
- Zhu Y, "Protective effect of 17β-estradiol upon hippocampal spine density and cognitive function in an animal model of vascular dementia", Sci Rep, 7, pp.42660~ (2017)
- Song MK, "Neurovascular integrative effects of long-term environmental enrichment on chronic cerebral hypoperfusion rat model", Brain Res Bull, 163, pp.160~169 (2020)
- Imai S, "NAD+ and sirtuins in aging and disease", Trends Cell Biol, 24, pp.464~471 (2014)
- Michán S, "SIRT1 is essential for normal cognitive function and synaptic plasticity", J Neurosci, 30, pp.9695~9707 (2010)
- 김태운, "Treadmill exercise ameliorates social isolation-induced memory impairment by enhancing silent information regulator-1 expression in rats", Journal of exercise rehabilitation, 16(3), pp.227~233 (2020), 한국운동재활학회[DOI]
- Lang X, "Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM", Brain Res Bull, 165, pp.30~39 (2020)
- Corpas R, "SIRT1 overexpression in mouse hippocampus induces cognitive enhancement through proteostatic and neurotrophic mechanisms", Mol Neurobiol, 54, pp.5604~5619 (2017)
- Sun Z, "Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion", Fluids Barriers CNS, 18, pp.21~ (2021)
- Liu H, "Cerebral hypoperfusion and cognitive impairment : the pathogenic role of vascular oxidative stress", Int J Neurosci, 122, pp.494~499 (2012)
- Xu L, "Improvement of autophagy dysfunction as a potential mechanism for environmental enrichment to protect blood-brain barrier in rats with vascular cognitive impairment", Neurosci Lett, 739, pp.135437~ (2020)
- Yang Y, "Blood-brain barrier breakdown in acute and chronic cerebrovascular disease", Stroke, 42, pp.3323~3328 (2011)
- Bell RD, "Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging", Neuron, 68, pp.409~427 (2010)