본문 바로가기
KERD
논문KCI 등재

Effects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review

0

조회

0

다운로드

0

인용

0

참고문헌

주제분류생화학

초록

The harmful effects of fine particulate matter ≤2.5 µm in size (PM2.5) on human health have received considerable attention. However, while the impact of PM2.5 on the respiratory and cardiovascular systems has been well studied, less is known about the effects on stem cells in the bone marrow (BM). With an emphasis on the invasive characteristics of PM2.5, this review examines the current knowledge of the health effects of PM2.5 exposure on BM-residing stem cells. Recent studies have shown that PM2.5 enters the circulation and then travels to distant organs, including the BM, to induce oxidative stress, systemic inflammation and epigenetic changes, resulting in the reduction of BM-residing stem cell survival and function. Understanding the broader health effects of air pollution thus requires an understanding of the invasive characteristics of PM2.5 and its direct influence on stem cells in the BM. As noted in this review, further studies are needed to elucidate the underlying processes by which PM2.5 disturbs the BM microenvironment and inhibits stem cell functionality. Strategies to prevent or ameliorate the negative effects of PM2.5 exposure on BM-residing stem cells and to maintain the regenerative capacity of those cells must also be investigated. By focusing on the complex relationship between PM2.5 and BM-resident stem cells, this review highlights the importance of specific measures directed at safeguarding human health in the face of rising air pollution.

Abstract

The harmful effects of fine particulate matter ≤2.5 µm in size (PM2.5) on human health have received considerable attention. However, while the impact of PM2.5 on the respiratory and cardiovascular systems has been well studied, less is known about the effects on stem cells in the bone marrow (BM). With an emphasis on the invasive characteristics of PM2.5, this review examines the current knowledge of the health effects of PM2.5 exposure on BM-residing stem cells. Recent studies have shown that PM2.5 enters the circulation and then travels to distant organs, including the BM, to induce oxidative stress, systemic inflammation and epigenetic changes, resulting in the reduction of BM-residing stem cell survival and function. Understanding the broader health effects of air pollution thus requires an understanding of the invasive characteristics of PM2.5 and its direct influence on stem cells in the BM. As noted in this review, further studies are needed to elucidate the underlying processes by which PM2.5 disturbs the BM microenvironment and inhibits stem cell functionality. Strategies to prevent or ameliorate the negative effects of PM2.5 exposure on BM-residing stem cells and to maintain the regenerative capacity of those cells must also be investigated. By focusing on the complex relationship between PM2.5 and BM-resident stem cells, this review highlights the importance of specific measures directed at safeguarding human health in the face of rising air pollution.

참고문헌 (171)

  1. Dockery, D. W., "An association between air pollution and mortality in six US cities", N. Engl. J. Med, 329, pp.1753~1759 (1993)
  2. Lippmann, M., "Deposition, retention, and clearance of inhaled particles", Br. J. Ind. Med, 37, pp.337~362 (1980)
  3. Kappos, A. D., "Health effects of particles in ambient air", Int. J. Hyg. Environ. Health, 207, pp.399~407 (2004)
  4. Kelly, F. J., "Air pollution and public health : emerging hazards and improved understanding of risk", Environ. Geochem. Health, 37, pp.631~649 (2015)
  5. Lee, M., "An analysis on the concentration characteristics of PM2.5 in Seoul, Korea from 2005 to 2012", Asia Pac. J. Atmos. Sci, 50, pp.585~594 (2014)
  6. "Research, N.I.o.E. (National Institute of Environmental Research Incheon, Korea", ~ (2017)
  7. Jia, H., "PM2.5‐induced pulmonary inflammation via activating of the NLRP3", caspase‐1 signaling pathway, 2021, pp.36, 298~307
  8. Duan, Z., "Effects of PM2. 5 exposure on Klebsiella pneumoniae clearance in the lungs of rats. Zhonghua jie he he hu xi za zhi= Zhonghua jiehe he huxi zazhi=Chin", J. tuberculosis respiratory Dis, 36, pp.836~840 (2013)
  9. Longhin, E., "Cell cycle alterations induced by urban PM2. 5 in bronchial epithelial cells: characterization of the process and possible mechanisms involved", Part. Fibre Toxicol, 10, pp.1~19 (2013)
  10. Jin, X. -T., "Progression and inflammation of human myeloid leukemia induced by ambient PM 2.5 exposure", Arch. Toxicol, 90, pp.1929~1938 (2016)
  11. Blank, F., "Translocation across the air-blood tissue barrier" (2014), CRC Press
  12. Reed, J. R., "Environmentally persistent free radical-containing particulate matter competitively inhibits metabolism by cytochrome P450 1A2", Toxicol. Appl. Pharmacol, 289, pp.223~230 (2015)
  13. Oberdörster, G., "Nanotoxicology : an emerging discipline evolving from studies of ultrafine particles", Environ. Health Perspect, 113, pp.823~839 (2005)
  14. Casals, E., "Distribution and potential toxicity of engineered inorganic nanoparticles and carbon nanos tructures in biological systems", TrAC Trends Anal. Chem, 27, pp.672~683 (2008)
  15. Xu, J. -J., "Relationship between PM 2. 5 exposure and pulmonary function in different working environments", J. Environ. Health, 30, pp.1~4 (2013)
  16. Xing, Y. -F., "The impact of PM2. 5 on the human respiratory system", J. Thorac. Dis, 8, pp.E69~ (2016)
  17. Cheng, Y., "Ambient PM2. 5 during pregnancy and risk on preterm birth. Zhonghua liu xing bing", xue za zhi= Zhonghua liuxingbingxue zazhi, 37, pp.572~577 (2016)
  18. Shu, Y., "Analysis of the relationship between PM2. 5 and lung cancer based on protein-protein interactions", Combinatorial Chem. high. throughput Screen, 19, pp.100~108 (2016)
  19. Wu, J., "Estimation of the PM 2.5 health effects in China during 2000–2011", Environ. Sci. Pollut. Res, 24, pp.10695~10707 (2017)
  20. Shi, T., "Association between PM2. 5 air pollution and daily resident mor tality in Guangzhou urban area in winter", J. Environ. Health, 32, pp.477~481 (2015)
  21. Chen, Y., "Environmental exposure and genetic predisposition as risk factors for asthma in China", Allergy, Asthma Immunol. Res, 8, pp.92~100 (2016)
  22. Zhang, Y., "Correlational study on atmospheric concentrations of fine par ticulate matter and children cough variant asthma", Eur. Rev. Med. Pharm. Sci, 20, pp.2650~2654 (2016)
  23. Xie, G., "Effects of PM2. 5 and its constituents on hemoglobin during the third trimester in pregnant women", Environ. Sci. Pollut. Res, 29, pp.35193~35203 (2022)
  24. Seita, J., "Hematopoietic stem cell: self‐renewal versus differ entiation", Wiley Interdiscip. Rev. : Syst. Biol. Med, 2, pp.640~653 (2010)
  25. Verovskaya, E. V., "Losing sense of self and surroundings: hematopoietic stem cell aging and leukemic transformation", Trends Mol. Med, 25, pp.494~515 (2019)
  26. Till, J. E., "A direct measurement of the radiation sensitivity of normal mouse bone marrow cells", Radiat. Res, 178, pp.AV3~AV7 (2012)
  27. Wei, Q., "Niches for hematopoietic stem cells and their progeny", Immunity, 48, pp.632~648 (2018)
  28. Yamada, T., "Genetic control of quiescence in hematopoietic stem cells", Cell Cycle, 12, pp.2376~2383 (2013)
  29. Cabezas-Wallscheid, N., "Vitamin A-retinoic acid signaling regulates hema topoietic stem cell dormancy", Cell, 169, pp.807~823 (2017)
  30. Shenghui, H., "Mechanisms of stem cell self-renewal", Annu. Rev. Cell Developmental, 25, pp.377~406 (2009)
  31. Hinge, A., "Asymmetrically segregated mitochondria provide cellular memory of hematopoietic stem cell replicative history and drive HSC attrition", Cell Stem Cell, 26, pp.420~430 (2020)
  32. Inaba, M., "Asymmetric stem cell division : precision for robustness", Cell Stem Cell, 11, pp.461~469 (2012)
  33. Suda, T., "Hematopoietic stem cells and their niche", Trends Immunol, 26, pp.426~433 (2005)
  34. Majeti, R., "Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood", Cell Stem Cell, 1, pp.635~645 (2007)
  35. Dominici, M., "Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement", Cytotherapy, 8, pp.315~317 (2006)
  36. Pittenger, M. F., "Multilineage potential of adult human mesenchymal stem cells", Science, 284, pp.143~147 (1999)
  37. Wagner, W., "Comparative characteristics of mesenchymal stem cells from human bone marrow, adipose tissue, and umbilical cord blood", Exp. Hematol, 33, pp.1402~1416 (2005)
  38. Zhang, X., "Runx2 overexpression enhances osteoblastic differentiation and mineralization in adipose-derived stem cells in vitro and in vivo", Calcif. tissue Int, 79, pp.169~178 (2006)
  39. Kita, K., "Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane", Stem Cells Dev, 19, pp.491~502 (2010)
  40. Ullah, I., "Human mesenchymal stem cells-current trends and future prospective", Biosci. Rep, 35, pp.1~18 (2015)
  41. Ranera, B., "Expansion under hypoxic conditions enhances the chondro genic potential of equine bone marrow-derived mesenchymal stem cells", Vet. J, 195, pp.248~251 (2013)
  42. Zhang, X., "Isolation and characterization of mesenchymal stem cells from human umbilical cord blood : reevaluation of critical factors for successful iso lation and high ability to proliferate and differentiate to chondrocytes as compared to mesenchymal stem cells from bone marrow and adipose tissue", J. Cell. Biochem, 112, pp.1206~1218 (2011)
  43. Gronthos, S., "The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors", Blood, 84, pp.4164~4173 (1994)
  44. Muruganandan, S., "Adipocyte differentiation of bone marrow-derived mesenchymal stem cells : cross talk with the osteoblastogenic program", Cell. Mol. life Sci, 66, pp.236~253 (2009)
  45. Stock, P., "Human bone marrow mesenchymal stem cell-derived hepatocytes improve the mouse liver after acute acetaminophen intoxication by preventing progress of injury", Int. J. Mol. Sci, 15, pp.7004~7028 (2014)
  46. Xu, W., "Mesenchymal stern cells from adult human bone marrow differ entiate into a cardiomyocyte phenotype in vitro", Exp. Biol. Med, 229, pp.623~631 (2004)
  47. Tang, D. -Q., "In vitro generation of functional insulin-producing cells from human bone marrow-derived stem cells, but long-term culture running risk of malignant transformation", Am. J. Stem Cells, 1, pp.114~ (2012)
  48. Phadnis, S. M., "Human bone marrow-derived mesenchymal cells differ entiate and mature into endocrine pancreatic lineage in vivo", Cytotherapy, 13, pp.279~293 (2011)
  49. Gabr, M. M., "Insulin-producing cells from adult human bone marrow mesenchymal stem cells control streptozotocin-induced diabetes in nude mice", Cell Transplant, 22, pp.133~145 (2013)
  50. Barzilay, R., "Lentiviral delivery of LMX1a enhances dopaminergic phenotype in differentiated human bone marrow mesenchymal stem cells", Stem Cells Dev, 18, pp.591~602 (2009)
  51. Wilkins, A., "Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro", Stem Cell Res, 3, pp.63~70 (2009)
  52. Bhattarai, G., "Maternal exposure to fine particulate matter during pregnancy induces progressive senescence of hematopoietic stem cells under preferential impairment of the bone marrow microenvironment and aids development of myeloproliferative disease", Leukemia, 34, pp.1481~1484 (2020)
  53. Bové, H., "Ambient black carbon particles reach the fetal side of human placenta", Nat. Commun, 10, pp.3866~ (2019)
  54. Leachi, H. F. L., "Polycyclic aromatic hydrocarbons and development of respiratory and cardiovascular diseases in workers", Rev. Bras. Enferm, 73, pp.e20180965~ (2020)
  55. Alegbeleye, O. O., "Polycyclic aromatic hydro carbons : a critical review of environmental occurrence and bioremediation", Environ. Manag, 60, pp.758~783 (2017)
  56. Zhao, C. -N., "Emerging role of air pollution in autoimmune diseases", Auto immun. Rev, 18, pp.607~614 (2019)
  57. Puri, P., "Effects of air pollution on the skin:A review", Indian J. Dermatol. Venereol. Leprol, 83, pp.415~ (2017)
  58. Ashmore, M.R., "World Atlas of Atmospheric Pollution", pp.77~94 (2008)
  59. Grzywa-Celińska, A., "‘Smoging kills’-effects of air pollution on human respiratory system", Ann. Agric. Environ. Med, 27, pp.1~5 (2020)
  60. Kitamura, H., "Impact of secondary generated minerals on toxic element immobilization for air pollution control fly ash of a municipal solid waste incinerator", Environ. Sci. Pollut. Res, 25, pp.20700~20712 (2018)
  61. Švédová, B., "Concentration variability of water-soluble ions during the acceptable and exceeded pollution in an industrial region", Int. J. Environ. Res. Public Health, 17, pp.3447~ (2020)
  62. Shahrbaf, M. A., "pollution and cardiac arrhythmias: A comprehensive review", Curr. Probl. Cardiol, 46, pp.100649~ (2021)
  63. Bangar, V., "Elemental characteristics and source-apportionment of PM2. 5 during the post-monsoon season in Delhi, India", Front. Sustain. Cities, 3, pp.648551~ (2021)
  64. Luckett, W. P., "Origin and differentiation of the yolk sac and extraembryonic mesoderm in presomite human and rhesus monkey embryos", Am. J. Anat, 152, pp.59~97 (1978)
  65. Onoda, A., "Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle", Part. Fibre Toxicol, 14, pp.1~16 (2017)
  66. Lelieveld, J., "The contribution of outdoor air pollution sources to premature mortality on a global scale", Nature, 525, pp.367~371 (2015)
  67. Puett, R. C., "Relationship of leukaemias with long-term ambient air pollu tion exposures in the adult Danish population", Br. J. Cancer, 123, pp.1818~1824 (2020)
  68. Cui, Y., "Ambient fine particulate matter induces apoptosis of endothelial progenitor cells through reactive oxygen species formation", Cell. Physiol. Bio chem, 35, pp.353~363 (2015)
  69. Ge, J., "Combined exposure to formaldehyde and PM2. 5: Hematopoietic toxicity and molecular mechanism in mice", Environ. Int, 144, pp.106050~ (2020)
  70. Kaushansky, K., "Lineage-specific hematopoietic growth factors", N. Engl. J. Med, 354, pp.2034~2045 (2006)
  71. Chavakis, T., "Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation", Nat. Immunol, 20, pp.802~811 (2019)
  72. Ogawa, M., "Differentiation and proliferation of hematopoietic stem cells", Blood, 81, pp.2844~2853 (1993)
  73. Wright, D. E., "Phy siological migration of hematopoietic stem and progenitor cells", Science, 294, pp.1933~1936 (2001)
  74. Khurshid, S. S., "Indoor particulate reactive oxygen species concentrations", Environ. Res, 132, pp.46~53 (2014)
  75. Daher, N., "Oxidative potential and chemical speciation of size-resolved particulate matter(PM)at near-freeway and urban background sites in the greater Beirut area", Sci. Total Environ, 470, pp.417~426 (2014)
  76. Bhattarai, G., "Exposure of newborns to atmospherically relevant artificial particulate matter induces hematopoietic stem cell senescence", J. Hazard. Mater, 452, pp.131293~ (2023)
  77. Wang, Y., "PM2. 5 Increases Systemic Inflammatory Cells and Associated Disease Risks by Inducing NRF2-Dependent Myeloid-Biased Hematopoiesis in Adult Male Mice", Environ. Sci. Technol, 57, pp.7924~7937 (2023)
  78. Muller-Sieburg, C. E., "Myeloid biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness", Blood, 103, pp.4111~4118 (2004)
  79. Liu, L. -L., "Effects of Long-Term Exposure to PM2. 5 on Oxidative Stress Injury and Expression of Inflammatory Factors, NF-κB p65 and Cx43 in Bone Marrow of Mice", 10, pp.747286~ (2022)
  80. Cui, Y., "Ambient fine particulate matter suppresses in vivo proliferation of bone marrow stem cells through reactive oxygen species formation", PLoS One, 10, pp.e0127309~ (2015)
  81. Godri, K. J., "Particulate oxidative burden associated with firework activity", Environ. Sci. Technol, 44, pp.8295~8301 (2010)
  82. Banaclocha, M. M., "N-acetylcysteine protects against age-related increase in oxidized proteins in mouse synaptic mitochondria", Brain Res, 762, pp.256~258 (1997)
  83. Voghel, G., "Chronic treatment with N-acetyl-cystein delays cellular senes cence in endothelial cells isolated from a subgroup of atherosclerotic patients", Mech. Ageing Dev, 129, pp.261~270 (2008)
  84. Samper, E., "Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells", Blood, J. Am. Soc. Hematol, 99, pp.2767~2775 (2002)
  85. Chang-Chien, J., "Particulate matter causes telomere shortening and increase in cellular senescence markers in human lung epithelial cells", Ecotox icol. Environ. Saf, 222, pp.112484~ (2021)
  86. Park, B., "In International Forum of Allergy & Rhinology, Vol. 12", pp.1424~ (2022), Wiley Blackwell
  87. Tsai, J. J., "Nrf2 regulates haematopoietic stem cell function", Nat. Cell Biol, 15, pp.309~316 (2013)
  88. Dai, X., "Nrf2 : redox and metabolic regulator of stem cell state and function", Trends Mol. Med, 26, pp.185~200 (2020)
  89. Wang, Y., "Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells", Free Radic. Biol. Med, 48, pp.348~356 (2010)
  90. Wu, F., "The involvement of Nox4 in fine particulate matter exposure induced cardiac injury in mice", J. Toxicological Sci, 43, pp.171~181 (2018)
  91. Ito, K., "Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells", Nat. Med, 12, pp.446~451 (2006)
  92. Iwasa, H., "Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway", Genes Cells, 8, pp.131~144 (2003)
  93. Ma, Y., "Cadmium exposure triggers osteoporosis in duck via P2X7", PI3K, Sci. Total Environ, pp.2021, 750[DOI]
  94. Saha, H., "Changes in RANKL and osteoprotegerin expression after chronic exposure to indoor air pollution as a result of cooking with biomass fuel", J. Appl Toxicol, 36, pp.969~976 (2016)
  95. Abu-Elmagd, M., "Evaluation of the effects of airborne particulate matter on bone marrow-mesenchymal stem cells(BM-MSCs) : cellular, molecular and sys tems biological approaches", Int. J. Environ. Res. Public Health, 14, pp.440~ (2017)
  96. "SEER cancer statistics review, 1975–2007" (2009)[URL]
  97. Humphries, F., "RIP kinases : key decision makers in cell death and innate immunity", Cell Death Differ, 22, pp.225~236 (2015)
  98. Lee, M. -S., "Oxidative stress and systemic inflammation as modifiers of cardiac autonomic responses to particulate air pollution", Int. J. Cardiol, 176, pp.166~170 (2014)
  99. Corsini, E., "Comparison of wood smoke PM2. 5 obtained from the com bustion of FIR and beech pellets on inflammation and DNA damage in A549 and THP-1 human cell lines", Arch. Toxicol, 87, pp.2187~2199 (2013)
  100. Ostro, B., "Chronic PM2. 5 exposure and inflammation: determining sensitive subgroups in mid-life women", Environ. Res, 132, pp.168~175 (2014)
  101. Jin, X., "Crucial role of pro-inflammatory cytokines from respiratory tract upon PM2. 5 exposure in causing the BMSCs differ entiation in cells and animals", Oncotarget, 9, pp.1745~ (2018)
  102. Lambeth, J. D., "NOX enzymes and the biology of reactive oxygen", Nat. Rev. Immunol, 4, pp.181~189 (2004)
  103. Jin, X., "Amelioration of particulate matter-induced oxidative damage by vitamin C and quercetin in human bronchial epithelial cells", Chemosphere, 144, pp.459~466 (2016)
  104. Manz, M. G., "Emergency granulopoiesis", Nat. Rev. Immunol, 14, pp.302~314 (2014)
  105. Jacobsen, S. E. W., "Haematopoiesis in the era of advanced single-cell technologies", Nat. Cell Biol, 21, pp.2~8 (2019)
  106. Ambient air pollution: A global assessment of exposure and burden of disease, "Organization, W. H.", ~ (2016)
  107. Ferrucci, L., "Seminars in hematology, Vol. 45", pp.242~249 (2008), Elsevier
  108. Kido, T., "Particulate matter induces translocation of IL-6 from the lung to the systemic circulation", Am. J. Respir. Cell Mol. Biol, 44, pp.197~204 (2011)
  109. Wardoyo, A. Y., "How exposure to ultrafine and fine particles of car smoke can alter erythrocyte forms of male mice", Pol. J. Environ. Stud, 28, pp.2901~ (2019)
  110. Lavigne, É., "Maternal exposure to ambient air pollution and risk of early childhood cancers : a population-based study in Ontario, Canada", Environ. Int, 100, pp.139~147 (2017)
  111. Hvidtfeldt, U. A., "Residential exposure to PM2. 5 components and risk of childhood non-hodgkin lymphoma in Denmark: a nationwide register-based case-control Study", Int. J. Environ. Res. Public Health, 17, pp.8949~ (2020)
  112. Sanchez-Guerra, M., "Effects of particulate matter exposure on blood 5hydroxymethylation : results from the Beijing truck driver air pollution study", Epigenetics, 10, pp.633~642 (2015)
  113. Cortessis, V. K., "Environmental epigenetics : prospects for studying epige netic mediation of exposure–response relationships", Hum. Genet, 131, pp.1565~1589 (2012)
  114. Hou, L., "Environmental chemical exposures and human epigenetics", Int. J. Epidemiol, 41, pp.79~105 (2012)
  115. Madakashira, B. P., "DNA methylation, nuclear organization, and cancer", Front. Genet, 8, pp.76~ (2017)
  116. Koch, A., "Analysis of DNA methylation in cancer : location revisited", Nat. Rev. Clin. Oncol, 15, pp.459~466 (2018)
  117. Zhang, Z., "Long-term exposure to ambient particulate matter (PM2. 5) is associated with platelet counts in adults", Environ. Pollut, 240, pp.432~439 (2018)
  118. Robertson, S., "Ambient air pollution and thrombosis", Part. Fibre Toxicol, 15, pp.1~16 (2018)
  119. Brook, R. D., "Particulate matter air pollution and cardiovascular disease : an update to the scientific statement from the American Heart Association", Circulation, 121, pp.2331~2378 (2010)
  120. Liang, S., "Repeat dose exposure of PM2. 5 triggers the disseminated intravascular coagulation (DIC) in SD rats", Sci. Total Environ, 663, pp.245~253 (2019)
  121. Rückerl, R., "Associations between ambient air pollution and blood markers of inflammation and coagulation", fibrinolysis in susceptible populations, 2014, pp.70, 32~49
  122. Hajat, A., "Long-term exposure to air pollution and markers of inflammation, coagulation, and endothelial activation: a repeat-measures analysis in the Multi Ethnic Study of Atherosclerosis (MESA)", Epidemiol. (Camb., Mass.), 26, pp.310~ (2015)
  123. Hystad, P., "Associations of outdoor fine particulate air pollution and car diovascular disease in 157 436 individuals from 21 high-income, middle-income, and low-income countries(PURE) : a prospective cohort study", Lancet Planet Health, 4, pp.e235~e245 (2020)
  124. Gao, X., "Short-term exposure to PM2. 5 components and renal health:Findings from the Veterans Affairs Normative Aging Study", J. Hazard Mater, 420, pp.126557~ (2021)
  125. Liu, L., "Long-term exposure to fine particulate constituents and cardiovascular diseases in Chinese adults", J. Hazard Mater, 416, pp.126051~ (2021)
  126. Lao, X. Q., "Long-term exposure to ambient fine particulate matter (PM 2.5)and incident type 2 diabetes: a longitudinal cohort study", Diabetologia, 62, pp.759~769 (2019)
  127. Gilcrease, G. W., "Is air pollution affecting the disease activity in patients with systemic lupus erythematosus? State of the art and a systematic literature review", Eur. J. Rheumatol, 7, pp.31~ (2020)
  128. Pun, V. C., "Long-term PM2. 5exposure and respiratory, cancer, and cardiovascular mortality in older US adults", Am. J. Epidemiol, 186, pp.961~969 (2017)
  129. Essers, M. A., "IFNα activates dormant haematopoietic stem cells in vivo", Nature, 458, pp.904~908 (2009)
  130. Walter, D., "Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells", Nature, 520, pp.549~552 (2015)
  131. Pietras, E. M., "Chronic interleukin-1 exposure drives haematopoietic stem cells towards precocious myeloid differentiation at the expense of self-renewal", Nat. Cell Biol, 18, pp.607~618 (2016)
  132. Pronk, C. J., "Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors", J. Exp. Med, 208, pp.1563~1570 (2011)
  133. Makris, S., "Immune function and dysfunction are determined by lymphoid tissue efficacy", Dis. Model. Mech, 15, pp.dmm049256~ (2022)
  134. Jung, E. M., "Association between prenatal exposure to PM2. 5 and the increased risk of specified infant mortality in South Korea", Environ. Int, 144, pp.105997~ (2020)
  135. Ortigoza, A., "Association between ambient PM2· 5 and under-5, infant, and child mortality in Latin America, 2010–15: a longitudinal analysis", 5, pp.S16~ (2021)
  136. Bo, Y., "Associations of reduced ambient PM2. 5 level with lower plasma glucose concentration and decreased risk of type 2 diabetes in adults: a long itudinal cohort study", Am. J. Epidemiol, 190, pp.2148~2157 (2021)
  137. Hayes, R. B., "PM2. 5 air pollution and cause-specific cardiovascular disease mortality", Int J. Epidemiol, 49, pp.25~35 (2020)
  138. Bowe, B., "Particulate matter air pollution and the risk of incident CKD and progression to ESRD", J. Am. Soc. Nephrol, 29, pp.218~ (2018)
  139. Lee, J.-T. J. C., "Review of epidemiological studies on air pollution and health effects in children", Clin. Exp. Pediatr, 64, pp.3~ (2021)
  140. Li, G., "Effect of PM2. 5 pollution on perinatal mortality in China", Sci. Rep, 11, pp.7596~ (2021)
  141. Alman, B. L., "Associations between PM2. 5 and risk of preterm birth among liveborn infants", Ann. Epidemiol, 39, pp.46~53 (2019)
  142. Tao, R. -j, "PM2. 5 compromises antiviral immunity in influenza infection by inhibiting activation of NLRP3 inflammasome and expression of interferon-β.", Mol. Immunol, 125, pp.178~186 (2020)
  143. Prada, D., "Molecular and cellular mechanisms linking air pollution and bone damage", Environ. Res, 185, pp.109465~ (2020)
  144. Qiu, Y. -N., "PM2. 5 induces liver fibrosis via triggering ROS-mediated mitophagy", Ecotoxicol. Environ. Saf, 167, pp.178~187 (2019)
  145. Li, R., "Function of PM2. 5 in the pathogenesis of lung cancer and chronic airway inflammatory diseases", Oncol. Lett, 15, pp.7506~7514 (2018)
  146. Chen, S., "Effect of PM2. 5 on macrosomia in China: A nationwide pro spective cohort study", Pediatr. Obes, 15, pp.e12584~ (2020)
  147. Nääv, Å., "Urban PM2. 5 induces cellular toxicity, hormone dysregulation, oxidative damage, inflammation, and mitochondrial interference in the HRT8trophoblast cell line", Front Endocrinol. (Lausanne), 11, pp.75~ (2020)
  148. Zhou, S., "Ovarian dysfunction induced by chronic whole‐body PM2. 5exposure", Small, 16, pp.2000845~ (2020)
  149. "Ambient (outdoor) air quality and health. 2018", int, factsheets, pp.fs313, en
  150. Wu, J., "The association between long-term exposure to ambient air pol lution and bone strength in China", J. Clin. Endocrinol. Metab, 106, pp.e5097~e5108 (2021)
  151. Yang, Y., "Ambient air pollution, bone mineral density and osteoporosis : results from a national population-based cohort study", Chemosphere, 310, pp.136871~ (2023)
  152. Qiao, D., "Long-term exposure to air pollution might increase prevalence of osteoporosis in Chinese rural population", Environ. Res, 183, pp.109264~ (2020)
  153. Yu, P., "Associations between long-term exposure to PM2. 5 and site-specific cancer mortality: A nationwide study in Brazil between 2010 and 2018", Environ. Pollut, 302, pp.119070~ (2022)
  154. Morales-Ancajima, V. C., "Increased outdoor PM2. 5 concentration is asso ciated with moderate", severe anemia in children aged 6–59 months in Lima, Peru, 2019, pp.2019, 6127845~
  155. Honda, T., "Anemia prevalence and hemo globin levels are associated with long-term exposure to air pollution in an older population", Environ. Int, 101, pp.125~132 (2017)
  156. Visani, G., "Environmental nanoparticles are significantly over-expressed in acute myeloid leukemia", Leuk. Res, 50, pp.50~56 (2016)
  157. Giannoni, P., "Chronic lymphocytic leukemia cells impair osteoblastogenesis and promote osteoclastogenesis : role of TNFα, IL-6 and IL-11 cytokines", Hae matologica, 106, pp.2598~ (2021)
  158. Wells, A., "Systemic IL-6 effector response in mediating systemic bone loss following inhalation of organic dust", J. Interferon Cytokine Res, 37, pp.9~19 (2017)
  159. Calderón-Garcidueñas, L., "Exposure to urban air pollution and bone health in clinically healthy six-year-old children", Arh. Hig. Rada Toksikol, 64, pp.23~23 (2013)
  160. Chen, Y., "Probucol protects circulating endothelial progenitor cells from ambient PM2. 5 damage via inhibition of reactive oxygen species and inflam matory cytokine production in vivo", Exp. Ther. Med, 16, pp.4322~4328 (2018)
  161. Liberda, E. N., "Exposure to inhaled nickel nanoparticles causes a reduction in number and function of bone marrow endothelial progenitor cells", Inhal. Toxicol, 22, pp.95~99 (2010)
  162. Haberzettl, P., "Exposure to ambient air fine particulate matter prevents VEGF-induced mobilization of endothelial progenitor cells from the bone mar row", Environ. Health Perspect, 120, pp.848~856 (2012)
  163. O’Toole, T. E., "Episodic exposure to fine particulate air pollution decreases circulating levels of endothelial progenitor cells", Circ. Res, 107, pp.200~203 (2010)
  164. Yamaguchi, M., "Role of reactive oxygen species in the radiation response of human hematopoietic stem", progenitor cells, 2013, pp.8, e70503~
  165. Rodrigues-Moreira, S., "Low-dose irradiation promotes persistent oxidative stress and decreases self-renewal in hematopoietic stem cells", Cell Rep, 20, pp.3199~3211 (2017)
  166. Eliasson, P., "Hypoxia mediates low cell-cycle activity and increases the proportion of long-term–reconstituting hematopoietic stem cells during in vitro culture", Exp. Hematol, 38, pp.301~310 (2010)
  167. Ito, K., "Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells", Nature, 431, pp.997~1002 (2004)
  168. Renzi, M., "Short-term exposure to PM2. 5 and risk of venous throm boembolism: A case-crossover study", Thromb. Res, 190, pp.52~57 (2020)
  169. Cliff, R., "Effect of diesel exhaust inhalation on blood markers of inflam mation and neurotoxicity : a controlled, blinded crossover study", Inhal. Toxicol, 28, pp.145~153 (2016)
  170. Orona, N. S., "Acute exposure to Buenos Aires air particles(UAP-BA)induces local and systemic inflammatory response in middle-aged mice : A time course study", Environ. Pollut, 208, pp.261~270 (2016)
  171. Park, S. -R., "The impact of fine particulate matter(PM)on various beneficial functions of human endometrial stem cells through its key regulator SERPINB2", Exp. Mol. Med, 53, pp.1850~1865 (2021)

관련 논문AI추천

이 간행물의 다른 논문 (218건)