본문 바로가기
KERD
논문KCI 등재

Induction Chemotherapy as a Prognostication Index and Guidance for Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: The Concept of Chemo-Selection (KCSG HN13-01)

2

조회

0

다운로드

0

인용

0

참고문헌

키워드

주제분류의학일반

초록

Purpose: Certain patient subgroups who do not respond to induction chemotherapy (IC) show inherent chemoresistance in locally advanced head and neck squamous cell carcinoma (LA-HNSCC). This study aimed to assess the prognostic value of IC, and role of IC in guiding the selection of a definitive locoregional therapy. Materials and methods: Out of the 445 patients in multi-institutional LA-HNSCC cohort, 158 (36%) receiving IC were enrolled. The study outcome was to assess overall survival (OS) through IC responsiveness and its role to select subsequent treatments. Results: Among 135 patients who completed subsequent treatment following IC, 74% responded to IC (complete response in 17% and partial response in 58%). IC-non-responders showed 4.5 times higher risk of mortality than IC-responders (hazard ratio, 4.52; 95% confidence interval, 2.32 to 8.81; p < 0.001). Among IC-responders, 84% subsequently received definitive concurrent chemoradiotherapy (CCRT) and OS was not differed by surgery or CCRT (p=0.960). Regarding IC-non-responders, 54% received CCRT and 46% underwent surgery, and OS was poor in CCRT (24-month survival rate of 38%) or surgery (24-month survival rate of 63%). Conclusion: Response to IC is a favorable prognostic factor. For IC-responders, either surgery or CCRT achieved similar survival probabilities. For IC-non-responder, multidisciplinary approach was warranted reflecting patients' preference, morbidity, and prognosis.

Abstract

Purpose: Certain patient subgroups who do not respond to induction chemotherapy (IC) show inherent chemoresistance in locally advanced head and neck squamous cell carcinoma (LA-HNSCC). This study aimed to assess the prognostic value of IC, and role of IC in guiding the selection of a definitive locoregional therapy. Materials and methods: Out of the 445 patients in multi-institutional LA-HNSCC cohort, 158 (36%) receiving IC were enrolled. The study outcome was to assess overall survival (OS) through IC responsiveness and its role to select subsequent treatments. Results: Among 135 patients who completed subsequent treatment following IC, 74% responded to IC (complete response in 17% and partial response in 58%). IC-non-responders showed 4.5 times higher risk of mortality than IC-responders (hazard ratio, 4.52; 95% confidence interval, 2.32 to 8.81; p < 0.001). Among IC-responders, 84% subsequently received definitive concurrent chemoradiotherapy (CCRT) and OS was not differed by surgery or CCRT (p=0.960). Regarding IC-non-responders, 54% received CCRT and 46% underwent surgery, and OS was poor in CCRT (24-month survival rate of 38%) or surgery (24-month survival rate of 63%). Conclusion: Response to IC is a favorable prognostic factor. For IC-responders, either surgery or CCRT achieved similar survival probabilities. For IC-non-responder, multidisciplinary approach was warranted reflecting patients' preference, morbidity, and prognosis.

참고문헌 (23)

  1. Marur S, "Head and neck squamous cell carcinoma : update on epidemiology, diagnosis, and treatment", Mayo Clin Proc, 91, pp.386~396 (2016)
  2. Lee YG, "Treatment strategy and outcomes in locally advanced head and neck squamous cell carcinoma : a nationwide retrospective cohort study(KCSG HN13-01)", BMC Cancer, 20, pp.813~ (2020)
  3. Pignon JP, "Meta-analysis of chemotherapy in head and neck cancer(MACH-NC) : an update on 93 randomised trials and 17, 346 patients", Radiother Oncol, 92, pp.4~14 (2009)
  4. Brizel DM, "Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer", Int J Radiat Oncol Biol Phys, 58, pp.1418~1423 (2004)
  5. Cohen EE, "Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer", J Clin Oncol, 32, pp.2735~2743 (2014)
  6. Zhang L, "Induction chemotherapy with concurrent chemoradiotherapy versus concurrent chemoradiotherapy for locally advanced squamous cell carcinoma of head and neck : a meta-analysis", Sci Rep, 5, pp.10798~ (2015)
  7. Haddad RI, "Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck : role, controversy, and future directions", Ann Oncol, 29, pp.1130~1140 (2018)
  8. Gregoire V, "Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up", Ann Oncol, 21(Suppl 5), pp.v184~6 (2010)
  9. Janoray G, "Long-term results of a multicenter randomized phase III trial of induction chemotherapy with cisplatin, 5-fluorouracil, +", – docetaxel for larynx preservation, 2016, pp.108, djv368~
  10. 김률, "The Effect of Induction Chemotherapy Using Docetaxel, Cisplatin, and Fluorouracil on Survival in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Meta-Analysis", Cancer Research and Treatment, 48(3), pp.907~916 (2016), 대한암학회
  11. Kiong KL, "Meta-analysis of induction chemotherapy as a selection marker for chemoradiation in the head and neck", Laryngoscope, 128, pp.1594~1601 (2018)
  12. Ensley JF, "Correlation between response to cisplatinum-combination chemotherapy and subsequent radiotherapy in previously untreated patients with advanced squamous cell cancers of the head and neck", Cancer, 54, pp.811~814 (1984)
  13. Hong WK, "Sequential response patterns to chemotherapy and radiotherapy in head and neck cancer : potential impact of treatment in advanced laryngeal cancer", Prog Clin Biol Res, 201, pp.191~197 (1985)
  14. Department of Veterans Affairs Laryngeal Cancer Study Group, "Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer", N Engl J Med, 324, pp.1685~1690 (1991)
  15. Lefebvre JL, "Laryngeal preservation with induction chemotherapy for hypopharyngeal squamous cell carcinoma : 10-year results of EORTC trial 24891", Ann Oncol, 23, pp.2708~2714 (2012)
  16. Pointreau Y, "Randomized trial of induction chemotherapy with cisplatin and 5-fluorouracil with or without docetaxel for larynx preservation", J Natl Cancer Inst, 101, pp.498~506 (2009)
  17. Haddad R, "Induction chemotherapy followed by concurrent chemoradiotherapy(sequential chemoradiotherapy)versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer(PARADIGM) : a randomised phase 3 trial", Lancet Oncol, 14, pp.257~264 (2013)
  18. Geoffrois L, "Induction docetaxel platinum 5-FU(TPF)followed by cetuximab-radiotherapy(cetux-RT)versus concurrent chemo-radiotherapy(CT", RT)in patients with N2b, J Clin Oncol, pp.2016, 34(15 Suppl)[DOI]
  19. Marur S, "E1308 : phase II trial of induction chemotherapy followed by reduced-dose radiation and weekly cetuximab in patients with HPV-associated resectable squamous cell carcinoma of the oropharynx-ECOG-ACRIN Cancer Research Group", J Clin Oncol, 35, pp.490~497 (2017)
  20. Ernani V, "Oral cavity cancer : risk factors, pathology, and management", Oncology, 89, pp.187~195 (2015)
  21. Posner MR, "Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer", N Engl J Med, 357, pp.1705~1715 (2007)
  22. Lorch JH, "Induction chemotherapy with cisplatin and fluorouracil alone or in combination with docetaxel in locally advanced squamous-cell cancer of the head and neck : long-term results of the TAX 324 randomised phase 3 trial", Lancet Oncol, 12, pp.153~159 (2011)
  23. Blanchard P, "Taxane-cisplatin-fluorouracil as induction chemotherapy in locally advanced head and neck cancers : an individual patient data meta-analysis of the meta-analysis of chemotherapy in head and neck cancer group", J Clin Oncol, 31, pp.2854~2860 (2013)

관련 논문AI추천

Induction chemotherapy followed by concurrent chemoradiotherapy versus CCRT for locally advanced hypopharynx and base of tongue cancer백정환, 임성희, Dongryul Oh, Han-Sin Jeong, Jong-Mu Sun, Joohyun Hong, Keunchil Park, Man Ki Chung, Myung-Ju Ahn, Yong Chan Ahn, Young-Ik Son대한내과학회 · The Korean Journal of Internal Medicine2021 · 제36권 제1호The Effect of Induction Chemotherapy Using Docetaxel, Cisplatin, and Fluorouracil on Survival in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Meta-Analysis김률, 김동완, 김미소, 김범석, 김태민, 신정훈, 옥찬영, 한서경, 허대석대한암학회 · Cancer Research and Treatment2016 · 제48권 제3호The Efficacy of an Induction Chemotherapy Combination with Docetaxel, Cisplatin, and 5-FU Followed by Concurrent Chemoradiotherapy in Advanced Head and Neck Cancer김여경, 김형준, 양덕환, 이제중, 이준규, 임상철, 정웅기, 정익주, 조상희, Jae-Sook Ahn, Ok-Ki Kim대한암학회 · Cancer Research and Treatment2007 · 제39권 제3호Characteristics and treatment patterns in older patients with locally advanced head and neck cancer (KCSG HN13-01)김민경, 김범석, 김혜련, 김효정, 윤환중, 최진혁, Eun Joo Kang, Hee Kyung Ahn, Jii Bum Lee, Jin-Soo Kim, Jung Hye Kwon, Keon Uk Park, Keun-Wook Lee, Kyoung Eun Lee, Seong Hoon Shin, Sung-Bae Kim, Yun-Gyoo Lee대한내과학회 · The Korean Journal of Internal Medicine2022 · 제37권 제1호Analysis of the Prognostic Factors for Distant Metastasis after Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Head and Neck Cancer기용간, 김동원, 김동현, 김원택, 남지호, 설영미, 이병주, 이주혜, 이진춘, 최영진대한암학회 · Cancer Research and Treatment2015 · 제47권 제1호Adjuvant Postoperative Radiotherapy with or without Chemotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: The Importance of Patient Selection for the Postoperative Chemoradiotherapy강진형, 김민식, 김연실, 선동일, 송진호, 이상남, 이종훈대한암학회 · Cancer Research and Treatment2013 · 제45권 제1호

이 간행물의 다른 논문 (29건)

Recommendations for the Use of Next-Generation Sequencing and the Molecular Tumor Board for Patients with Advanced Cancer: A Report from KSMO and KCSG Precision Medicine Networking Group김효송, 천재경, 임선민, 윤지나, 장대영, 차용준, 강진형, 박인근, 이인희, 김한상, 홍용상, 장세진, 윤홍석, 안희경, 윤신교, 김태원, 유창훈, 김인호, 김지현, 김진원, 김지훈, 김승태, 김미소, 정재호pp. 1-9Validation of the Korean Version of the Patient-Reported Outcomes Measurement Information System 29 Profile V2.1 among Cancer Survivors윤정희, 임지현, 조주희, 남희수, 이만경, 복혜숙, 이상원, 김수연, 강은지, 안진석, 오동렬, 신수용, 김영하, 강단비, 심성근pp. 10-19Analysis of Cancer Patient Decision-Making and Health Service Utilization after Enforcement of the Life-Sustaining Treatment Decision-Making Act in Korea김달용, Dae Seog Heo, 임채만, 유신혜, 신성준, 김도연, Min Sun Kim, 이현정, 서세영, 임지연pp. 20-29Comparison of the Data of a Next-Generation Sequencing Panel from K-MASTER Project with That of Orthogonal Methods for Detecting Targetable Genetic Alterations신상원, 임승택, 장원진, 박경화, 이종원, 강은주, 조성심, 김정선, 임태규, 김혜숙, 김유정, 이수현, 최정윤, 김주원, 조장호, 안미선, 임아름, 김영생, 박지현, 이영우, 정희준, 김열홍, 최윤지, 성재숙pp. 30-39Targeted Liquid Biopsy Using Irradiation to Facilitate the Release of Cell-Free DNA from a Spatially Aimed Tumor Tissue박지현, 안원균, 노재명, 표홍렬, 박웅양, 이호연, 김연정, 최창훈, 이태섭, 박동현pp. 40-53