Efficacy of Inhaled Iloprost in Cor Pulmonale and Severe Pulmonary Hypertension Associated with Tuberculous Destroyed Lung
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Chronic obstructive pulmonary disease (COPD) is one of the causes of cor pulmonale. Cor pulmonale patients with pulmonaryhypertension have a significant lower survival rate than patients without. However, there is no conclusive treatment options incor pulmonale and pulmonary hypertension associated with COPD until now. We report a patient with cor pulmonale andpulmonary hypertension associated with severe form of COPD and tuberculous destroyed lung who achieved marked clinical,functional and echocardiographic hemodynamic improvements with inhaled iloprost for six months.
Abstract
Chronic obstructive pulmonary disease (COPD) is one of the causes of cor pulmonale. Cor pulmonale patients with pulmonaryhypertension have a significant lower survival rate than patients without. However, there is no conclusive treatment options incor pulmonale and pulmonary hypertension associated with COPD until now. We report a patient with cor pulmonale andpulmonary hypertension associated with severe form of COPD and tuberculous destroyed lung who achieved marked clinical,functional and echocardiographic hemodynamic improvements with inhaled iloprost for six months.
참고문헌 (9)
- Oswald-Mammosser M, "Prognostic factors in COPD patients receiving long-term oxygen therapy. Importance of pulmonary artery pressure", Chest, 107, pp.1193~1198 (1995)
- Hoeper MM, "Long-term treatment of primary pulmonary hypertension with aerosolized iloprost, a prostacyclin analogue", N Engl J Med, 342, pp.1866~1870 (2000)
- Opitz CF, "Clinical efficacy and survival with first-line inhaled iloprost therapy in patients with idiopathic pulmonary arterial hypertension", Eur Heart J, 26, pp.1895~1902 (2005)
- Boeck L, "Acute effects of aerosolized iloprost in COPD related pulmonary hypertension - a randomized controlled crossover trial", PLoS One, 7, pp.e52248~ (2012)
- Hegewald MJ, "Sustained improvement with iloprost in a COPD patient with severe pulmonary hypertension", Chest, 135, pp.536~537 (2009)
- Barberà JA, "Pulmonary hypertension in patients with chronic obstructive pulmonary disease : advances in pathophysiology and management", Drugs, 69, pp.1153~1171 (2009)
- Dernaika TA, "Iloprost improves gas exchange and exercise tolerance in patients with pulmonary hypertension and chronic obstructive pulmonary disease", Respiration, 79, pp.377~382 (2010)
- Wilkens H, "Influence of inhaled iloprost on transpulmonary gradient of big endothelin in patients with pulmonary hypertension", Circulation, 107, pp.1509~1513 (2003)
- Opitz CF, "Assessment of the vasodilator response in primary pulmonary hypertension. Comparing prostacyclin and iloprost administered by either infusion or inhalation", Eur Heart J, 24, pp.356~365 (2003)
