Knowledge and Attitudes of Indonesian General Practitioners Towards the Isoniazid Preventive Therapy Program in Indonesia
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Objectives: The Indonesian Ministry of Health launched isoniazid preventive therapy (IPT) in 2016, with general practitioners (GPs) at the frontline of this program. However, the extent to which GPs have internalized this program remains uncertain. The aim of this study was to identify the knowledge and attitudes of GPs towards the IPT program in Indonesia. Methods: This study used an online, self-administered questionnaire distributed via e-mail and social messaging services. A logistic regression model was employed to identify the explanatory variables influencing the level of knowledge and attitudes toward IPT among GPs in Indonesia. An empirical analysis was conducted separately for each response variable (knowledge and attitudes). Results: Of the 418 respondents, 128 (30.6%) had a good knowledge of IPT. Working at a public hospital was the only variable associated with good knowledge, with an adjusted odds ratio (aOR) of 1.69 (95% confidence interval [CI], 1.02 to 2.81). Furthermore, 279 respondents (66.7%) had favorable attitudes toward IPT. In the adjusted logistic regression analysis, good knowledge (aOR, 0.55; 95% CI, 0.34 to 0.89), 1-5 years of work experience (aOR, 2.09; 95% CI, 1.21 to 3.60), and having experienced IPT training (aOR, 0.48; 95% CI, 0.25 to 0.93), were significantly associated with favorable attitudes. Conclusions: In general, GPs in Indonesia had favorable attitudes toward IPT. However, their knowledge of IPT was limited. GPs are an essential element of the IPT program in the country, and therefore, adequate information dissemination to improve their understanding is critical for the long-term viability and quality of the IPT program in Indonesia.
Abstract
Objectives: The Indonesian Ministry of Health launched isoniazid preventive therapy (IPT) in 2016, with general practitioners (GPs) at the frontline of this program. However, the extent to which GPs have internalized this program remains uncertain. The aim of this study was to identify the knowledge and attitudes of GPs towards the IPT program in Indonesia. Methods: This study used an online, self-administered questionnaire distributed via e-mail and social messaging services. A logistic regression model was employed to identify the explanatory variables influencing the level of knowledge and attitudes toward IPT among GPs in Indonesia. An empirical analysis was conducted separately for each response variable (knowledge and attitudes). Results: Of the 418 respondents, 128 (30.6%) had a good knowledge of IPT. Working at a public hospital was the only variable associated with good knowledge, with an adjusted odds ratio (aOR) of 1.69 (95% confidence interval [CI], 1.02 to 2.81). Furthermore, 279 respondents (66.7%) had favorable attitudes toward IPT. In the adjusted logistic regression analysis, good knowledge (aOR, 0.55; 95% CI, 0.34 to 0.89), 1-5 years of work experience (aOR, 2.09; 95% CI, 1.21 to 3.60), and having experienced IPT training (aOR, 0.48; 95% CI, 0.25 to 0.93), were significantly associated with favorable attitudes. Conclusions: In general, GPs in Indonesia had favorable attitudes toward IPT. However, their knowledge of IPT was limited. GPs are an essential element of the IPT program in the country, and therefore, adequate information dissemination to improve their understanding is critical for the long-term viability and quality of the IPT program in Indonesia.
참고문헌 (28)
- MacNeil A, "Global epidemiology of tuberculosis and progress toward meeting global targets - worldwide, 2018", MMWR Morb Mortal Wkly Rep, 69(11), pp.281~285 (2020)
- Chakaya J, "Global tuberculosis report 2020 - reflections on the global tb burden, treatment and prevention efforts", Int J Infect Dis, 113(Suppl 1), pp.S7~S12 (2021)
- Zumla A, "Advances in the development of new tuberculosis drugs and treatment regimens", Nat Rev Drug Discov, 12(5), pp.388~404 (2013)
- Burke RM, "Community-based active case-finding interventions for tuberculosis : a systematic review", Lancet Public Health, 6(5), pp.e283~e299 (2021)
- GBD Tuberculosis Collaborators, "The global burden of tuberculosis : results from the Global Burden of Disease Study 2015", Lancet Infect Dis, 18(3), pp.261~284 (2018)
- Chaudhary R, "Diagnostic performance of GeneXpert MTB", RIF assay compared to conventional Mycobacterium tuberculosis culture for diagnosis of pulmonary and extrapulmonary tuberculosis, Nepal, 2021, pp.1(2), e33~
- Jeremiah C, "The WHO global tuberculosis 2021 report - not so good news and turning the tide back to End TB", Int J Infect Dis (2022)
- Uplekar M, "WHO’s End TB Strategy : from stopping to ending the global TB epidemic", Indian J Tuberc, 62(4), pp.196~199 (2015)
- Houben RM, "The global burden of latent tuberculosis infection : a re-estimation using mathematical modelling", PLoS Med, 13(10), pp.e1002152~ (2016)
- Ayele HT, "Isoniazid prophylactic therapy for the prevention of tuberculosis in HIV infected adults : a systematic review and meta-analysis of randomized trials", PLoS One, 10(11), pp.e0142290~ (2015)
- Mandal S, "The potential impact of preventive therapy against tuberculosis in the WHO South-East Asian Region : a modelling approach", BMC Med, 18(1), pp.163~ (2020)
- Ross JM, "Isoniazid preventive therapy plus antiretroviral therapy for the prevention of tuberculosis : a systematic review and meta-analysis of individual participant data", Lancet HIV, 8(1), pp.e8~e15 (2021)
- Huang CC, "Isoniazid preventive therapy in contacts of multidrug-resistant tuberculosis", Am J Respir Crit Care Med, 202(8), pp.1159~1168 (2020)
- Ayele HT, "Predictors of adherence to isoniazid preventive therapy in people living with HIV in Ethiopia", Int J Tuberc Lung Dis, 20(10), pp.1342~1347 (2016)
- Smieja MJ, "Isoniazid for preventing tuberculosis in non-HIV infected persons", Cochrane Database Syst Rev, 1999(2), pp.CD001363~ (2000)
- Collins D, "The economic burden of tuberculosis in Indonesia", Int J Tuberc Lung Dis, 21(9), pp.1041~1048 (2017)
- "Technical instructions for handling latent tuberculosis infection (ILTB)" (2020)[URL]
- "Regulation of the Minister of Health number 67 year 2016 on tuberculosis control"[URL]
- Reviono R, "The dynamic of tuberculosis case finding in the era of the public-private mix strategy for tuberculosis control in Central Java, Indonesia", Glob Health Action, 10(1), pp.1353777~ (2017)
- Mahendradhata Y, "How do private general practitioners manage tuberculosis cases? A survey in eight cities in Indonesia", BMC Res Notes, 8, pp.564~ (2015)
- Durovni B, "The implementation of isoniazid preventive therapy in HIV clinics: the experience from the TB", HIV in Rio (THRio) study, 2010, pp.24(Suppl 5), S49~S56
- Abdulrazaak AT, "Knowledge, attitudes and practices of doctors regarding isoniazid preventive therapy in HIV", AIDS patients at Odi District Hospital, Gauteng province, South Africa, 2018, pp.33(5), 1~11
- Martinson NA, "New regimens to prevent tuberculosis in adults with HIV infection", N Engl J Med, 365(1), pp.11~20 (2011)
- Surya A, "Quality tuberculosis care in Indonesia: using patient pathway analysis to optimize public-private collaboration", J Infect Dis, 216(Suppl_7), pp.S724~S732 (2017)
- Suryanto, "Healthcare system in Indonesia", Hosp Top, 95(4), pp.82~89 (2017)
- Bateman C, "Doctor IPT ignorance contributing to TB epidemic--study", S Afr Med J, 101(2), pp.88~ (2011)
- Teklay G, "Barriers in the implementation of isoniazid preventive therapy for people living with HIV in Northern Ethiopia : a mixed quantitative and qualitative study", BMC Public Health, 16(1), pp.840~ (2016)
- van Halsema CL, "Tuberculosis outcomes and drug susceptibility in individuals exposed to isoniazid preventive therapy in a high HIV prevalence setting", AIDS, 24(7), pp.1051~1055 (2010)