Relationship between Blood Mercury Concentration and Bone Mineral Density in Korean Men in the 2008–2010 Korean National Health and Nutrition Examination Survey
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Background: The results of previous studies on the association between blood mercury (Hg) and bone mineral density (BMD) are inconsistent. We therefore used a large-scale nationwide representative sample of Korean men to investigate the relationship between these two parameters.Methods: A nationwide cross-sectional study was conducted using data from the 2008 to 2010 Korean National Health and Nutrition Examination Survey to evaluate the relationship between blood Hg and BMD and the preva-lence of osteopenia or osteoporosis in 1,190 men over 50 years of age. BMD was measured by dual-energy X-ray absorptiometry. Osteopenia and osteoporosis were diagnosed for each body site according to World Health Orga-nization T-score criteria.Results: After adjusting for age, body mass index, caloric energy and calcium intake, vitamin D levels, fish con-sumption, alcohol consumption, smoking, and exercise, quartiles of blood Hg were positively associated with fe-mur neck T-scores in multiple linear regression analysis (β=0.06, P-value=0.03). Compared with the lowest blood Hg quartile, the odds ratios and 95% confidence intervals for diagnosis of osteopenia or osteoporosis in the second and fourth quartiles were 0.63 (0.41–0.99) and 0.57 (0.36–0.91), respectively, in the femur neck after adjusting for the same co-variables.Conclusion: High blood Hg levels were associated with reduced odds of decreased femur neck BMD in Korean men. However, subgroup analysis did not show a significant protective effect of blood Hg on osteoporotic fractures. Further research is necessary to clarify the association between blood Hg and BMD.
Abstract
Background: The results of previous studies on the association between blood mercury (Hg) and bone mineral density (BMD) are inconsistent. We therefore used a large-scale nationwide representative sample of Korean men to investigate the relationship between these two parameters.Methods: A nationwide cross-sectional study was conducted using data from the 2008 to 2010 Korean National Health and Nutrition Examination Survey to evaluate the relationship between blood Hg and BMD and the preva-lence of osteopenia or osteoporosis in 1,190 men over 50 years of age. BMD was measured by dual-energy X-ray absorptiometry. Osteopenia and osteoporosis were diagnosed for each body site according to World Health Orga-nization T-score criteria.Results: After adjusting for age, body mass index, caloric energy and calcium intake, vitamin D levels, fish con-sumption, alcohol consumption, smoking, and exercise, quartiles of blood Hg were positively associated with fe-mur neck T-scores in multiple linear regression analysis (β=0.06, P-value=0.03). Compared with the lowest blood Hg quartile, the odds ratios and 95% confidence intervals for diagnosis of osteopenia or osteoporosis in the second and fourth quartiles were 0.63 (0.41–0.99) and 0.57 (0.36–0.91), respectively, in the femur neck after adjusting for the same co-variables.Conclusion: High blood Hg levels were associated with reduced odds of decreased femur neck BMD in Korean men. However, subgroup analysis did not show a significant protective effect of blood Hg on osteoporotic fractures. Further research is necessary to clarify the association between blood Hg and BMD.
참고문헌 (24)
- Kim LO, "A new predictive index for osteoporosis in men under 70 years of age: an index to identify male candidates for osteoporosis screening by bone mineral density", J Osteoporos, 2014, pp.781897~ (2014)
- 박은정, "Prevalence of Osteoporosis in the Korean Population Based on Korea National Health and Nutrition Examination Survey (KNHANES), 2008--2011", Yonsei Medical Journal, 55(4), pp.1049~1057 (2014), 연세대학교의과대학[DOI]
- "Osteoporosis in men" (2015)[URL]
- Willson T, "The clinical epidemiology of male osteoporosis: a review of the recent literature", Clin Epidemiol, 7, pp.65~76 (2015)
- "Toxicology profile for mercury" (1999)[URL]
- Jarup L, "Hazards of heavy metal contamination", Br Med Bull, 68, pp.167~182 (2003)
- 유창훈, "Relationship between Dietary Mercury Intake and Blood Mercury Level in Korea", Journal of Korean Medical Science, 29(2), pp.176~182 (2014), 대한의학회
- Weil M, "Blood mercury levels and neurobehavioral function", JAMA, 293, pp.1875~1882 (2005)
- Lee YJ, "Relationship between serum ferritin level and blood mercury concentration using data from the Korean national health and nutrition examination survey (2010-2012)", Environ Res, 135, pp.271~275 (2014)
- Brito JA, "Changes in bone Pb accumulation: cause and effect of altered bone turnover", Bone, 64, pp.228~234 (2014)
- Engstrom A, "Associations between dietary cadmium exposure and bone mineral density and risk of osteoporosis and fractures among women", Bone, 50, pp.1372~1378 (2012)
- Cho GJ, "The relationship between blood mercury level and osteoporosis in postmenopausal women", Menopause, 19, pp.576~581 (2012)
- Pollack AZ, "Bone mineral density and blood metals in premenopausal women", Environ Res, 120, pp.76~81 (2013)
- Suzuki N, "Both mercury and cadmium directly influence calcium homeostasis resulting from the suppression of scale bone cells: the scale is a good model for the evaluation of heavy metals in bone metabolism", J Bone Miner Metab, 22, pp.439~446 (2004)
- Bolam KA, "The effect of physical exercise on bone density in middle-aged and older men: a systematic review", Osteoporos Int, 24, pp.2749~2762 (2013)
- Vahter M, "Gender differences in the disposition and toxicity of metals", Environ Res, 104, pp.85~95 (2007)
- Warming L, "Changes in bone mineral density with age in men and women: a longitudinal study", Osteoporos Int, 13, pp.105~112 (2002)
- Lee KM, "Genderand body-site-specific factors associated with bone mineral density in a non-institutionalized Korean population aged ≥50 years", J Bone Miner Metab, 33, pp.401~409 (2015)
- Yachiguchi K, "Effects of inorganic mercury and methylmercury on osteoclasts and osteoblasts in the scales of the marine teleost as a model system of bone", Zoolog Sci, 31, pp.330~337 (2014)
- Riggs BL, "The mechanisms of estrogen regulation of bone resorption", J Clin Invest, 106, pp.1203~1204 (2000)
- Wang YD, "Experiment study on the estrogenlike effect of compounds of mercury, chromium and manganese", Wei Sheng Yan Jiu, 34, pp.49~51 (2005)
- Davis BJ, "Mercury vapor and female reproductive toxicity", Toxicol Sci, 59, pp.291~296 (2001)
- Bernhoft RA, "Mercury toxicity and treatment: a review of the literature", J Environ Public Health, 2012, pp.460508~ (2012)
- Kim Y, "Association between blood lead and mercury levels and periodontitis in the Korean general population: analysis of the 2008-2009 Korean National Health and Nutrition Examination Survey data", Int Arch Occup Environ Health, 86, pp.607~613 (2013)