Clinical Characteristics of Primary Peritoneal Carcinoma
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Abstract
Purpose: The goal of this study was to determine the clinical and therapeutic characteristics of women with a primary peritoneal carcinoma (PPC). Materials and Methods: A retrospective clinical study was conducted to evaluate 22 women diagnosed with a PPC from 1993 to 2007 at the Hospitals of The Catholic University of Korea. Diagnoses were based on the Gynecologic Oncology Group criteria and clinical data. We collected patient clinicopathological data including age, presenting symptoms, pretreatment CA-125 values (U/ml), clinical stage (based on the FIGO stage), performance status (using the Eastern Cooperative Oncology Group scale), whether cytoreductive surgery was optimal or not, types of chemotherapy and response to treatment. We evaluated the clinical characteristics and response to treatment, time to treatment failure and overall survival. Results: The median overall survival of all patients was 23.1 months. The estimated 3-year survival rate was 29% (SE, 13%). The response rate to first-line platinum-based chemotherapy was 79% and the median time to treatment failure was 9.9 months (95% confidence interval, 1.38～18.4 months). By univariate and multivariate analysis, performance status was the only significant factor associated with overall survival (p＜0.05). Conclusion: We evaluated the clinical characteristics and treatment response of patients with a primary peritoneal carcinoma. Our results showed that it is possible to achieve long-term survival in patients with PPC. A further clinical study is to need to establish clinical characteristics and treatment outcomes. (Cancer Res Treat. 2007;39:65-68)
참고문헌 (19)
- "Swerdlow M. Mesothelioma of the pelvic peritoneum resembling papillary cystadenocarcinoma of the ovary; case report. Am J Obstet Gynecol. 1959;77"
- Fromm GL, "Silva EG. Papillary serous carcinoma of the peritoneum. Obstet Gynecol. 1990;75", pp.89~95
- Ransom DT, "Edmonson JH. Papillary serous carcinoma of the peritoneum. A review of 33 cases treated with platin-based chemotherapy. Cancer. 1990;66", pp.1091~4
- Bloss JD, "a case-control retrospective comparison to papillary adenocarcinoma of the ovary. Gynecol Oncol. 1993;50", pp.347~51
- Chu CS, "Primary peritoneal carcinoma: a review of the literature", 54, pp.323~335 (1999)
- Cormio G, "Primary peritoneal carcinoma: a report of twelve cases and a review of the literature", 50, pp.203~206 (2000)
- Barda G, "Comparison between primary peritoneal and epithelial ovarian carcinoma: a population-based study", 190, pp.1039~1045 (2004)
- World Health Organization, "WHO Handbook for Reporting Results of Cancer Treatment G" (1979)
- Mills SE, "Austin MB. Serous surface papillary carcinoma. A clinicopathologic study of 10 cases and comparison with stage III-IV ovarian serous carcinoma. Am J Surg Pathol. 1988;12", pp.827~34
- Dalrymple JC, "et al. Extraovarian peritoneal serous papillary carcinoma. A clinicopathologic study of 31 cases. Cancer. 1989;64", pp.110~5
- Weiss NS, "Young JL Jr. Incidence of the histologic types of ovarian cancer", pp.161~7
- Taus P, "Primary serous papillary carcinoma of the peritoneum: a report of 18 patients", 18, pp.171~172 (1997)
- Chen KT, "Flam MS. Peritoneal papillary serous carcinoma with long-term survival. Cancer. 1986;58", pp.1371~3
- Bloss JD, "Extraovarian peritoneal serous papillary carcinoma: a phase II trial of cisplatin and cyclophosphamide with comparison to a cohort with papillary serous ovarian carcinoma-a Gynecologic Oncology Group Study", 89, pp.148~154 (2003)
- Skates S, "Longitudinal CA125 detection of sporadic papillary serous carcinoma of the peritoneum", 13, pp.693~696 (2003)
- Karlan BY, "Peritoneal serous papillary carcinoma, a phenotypic variant of familial ovarian cancer: implications for ovarian cancer screening", 180, pp.917~928 (1999)
- Truong LD, "Kaplan AL. Serous surface carcinoma of the peritoneum a clinicopathologic study of 22 cases. Human pathology. 1990; 21", pp.99~110
- Dubernard G, "Prognosis of stage III or IV primary peritoneal serous papillary carcinoma", 30, pp.976~981 (2004)
- Kowalski LD, "A case-matched molecular comparison of extraovarian versus primary ovarian adenocarcinoma", 79, pp.1587~1594 (1997)