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Antioxidant Property of Vitamin C - in Comparison with Vitamin B1

김정희|서두교
대한구강생물학회 (Korean Academy Of Oral Biology)|2005.12|International Journal of Oral Biology|제30권 제4호|pp. 117-123

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주제분류치의학

초록

Abstract

Various aspects of antioxidant activity in vitamin C were evaluated in this study. Relatively high level of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was detected in vitamin C, but not in non-antioxidative vitamin, vitamin B1. Vitamin C also reduced the production of lipid peroxidation in Chinese hamster lung fibroblast (V79-4) cells with IC50 value of 4 μg/ml. Vitamin B1 showed comparable reduction in lipid peroxidation products (IC50 value was about 10 μg/ml). It was shown that vitamin C also dosedependently enhanced the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in V79-4 cells, and these effects were not observed in vitamin B1-treated cells. Our data suggest that well-known antioxidant vitamin C involved in direct activation of SOD, CAT and GPX.

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