Comparison of local reaction at injection site following intramuscular administration with three commercial atrophic rhinitis vaccines in pigs
2
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Bordetella bronchiseptica and Pasteurella multocida are two main pathogens responsible for atrophic rhinitis (AR), which causes considerable economic losses in swine industry worldwide. Commercial vac-cine has been widely used to prevent the damage from AR in Korea. Adverse effects of vaccination at the injection site have been reported, which results in the numerous complaint from farms. However, data on about local reaction at the injection site remains limited. In this study, we compared the local adverse effects of three commercial vaccines following intramuscular injection. The results showed that no gross lesion was founded at the injection sites of all three vaccines. In histopathologic examination, a various level of lesions was identified. Especially, the local reaction of vaccine including saponin as an adjuvant showed the lowest level of histopathological lesions, when compared to those of oil-based and vitamin E-based vaccines. Therefore, this study would provide the information about the extent of local reaction at the injection site and help the farmer to select AR vaccine in order to avoid adverse reaction due to vaccination.
Abstract
Bordetella bronchiseptica and Pasteurella multocida are two main pathogens responsible for atrophic rhinitis (AR), which causes considerable economic losses in swine industry worldwide. Commercial vac-cine has been widely used to prevent the damage from AR in Korea. Adverse effects of vaccination at the injection site have been reported, which results in the numerous complaint from farms. However, data on about local reaction at the injection site remains limited. In this study, we compared the local adverse effects of three commercial vaccines following intramuscular injection. The results showed that no gross lesion was founded at the injection sites of all three vaccines. In histopathologic examination, a various level of lesions was identified. Especially, the local reaction of vaccine including saponin as an adjuvant showed the lowest level of histopathological lesions, when compared to those of oil-based and vitamin E-based vaccines. Therefore, this study would provide the information about the extent of local reaction at the injection site and help the farmer to select AR vaccine in order to avoid adverse reaction due to vaccination.
참고문헌 (13)
- Ackermann MR., "Experimental model of atrophic rhinitis in gnotobiotic pigs", Infect Immun, 59, pp.3626~3629 (1991)
- Brockmeier SL., "Role of the dermonecrotic toxin of Bordetella bronchiseptica in the pathogenesis of respiratory disease in swine", Infect Immun, 70, pp.481~490 (2002)
- Burakova Y., "Adjuvants for animal vaccines", Viral Immunol, 31, pp.11~22 (2018)
- Cox JC., "Adjuvants—a classification and review of their modes of action", Vaccine, 15, pp.248~256 (1997)
- Haesebrouck F., "Efficacy of vaccines against bacterial diseases in swine: what can we expect?", Vet Microbiol, 100, pp.255~268 (2004)
- 이수진, "Recent Advances of Vaccine Adjuvants for Infectious Diseases", Immune Network, 15(2), pp.51~57 (2015), 대한면역학회
- Lee WH., "Suggested guidelines for vaccination of pigs in Korea", Clin Exp Vaccine Res, 4, pp.119~120 (2015)
- Lyons NA., "Challenges of generating and maintaining protective vaccine-induced immune responses for foot-and-mouth disease virus in pigs", Front Vet Sci, 3, pp.102~ (2016)
- Opriessnig T., "Polymicrobial respiratory disease in pigs", Anim Health Res Rev, 12, pp.133~148 (2011)
- 박유리, "시판 백신접종 스트레스 완화제의 돼지 구제역 백신 접종부위 부작용 발생 저감 효과 평가", 한국동물위생학회지, 40(3), pp.177~185 (2017), 한국동물위생학회
- Pedersen KB., "The pathogenesis of atrophic rhinitis in pigs induced by toxigenic Pasteurella multocida", J Comp Pathol, 94, pp.203~214 (1984)
- Petrovsky N., "Comparative safety of vaccine adjuvants: A summary of current evidence and future needs", Drug Saf, 38, pp.1059~1074 (2015)
- Roth JA., "Mechanistic bases for adverse vaccine reactions and vaccine failures", Adv Vet Med, 41, pp.681~700 (1999)