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제2형 당뇨 동물모델을 이용한 방풍통성산의 고혈당 개선효과

Anti-hyperglycemic Effect of Bangpungtongseong-san on Type II Diabetes Animal Models

조현우|노종현|고문희
한국약용작물학회|2020.08|한국약용작물학회지 (KOREAN JOURNAL OF MEDICINAL CROP SCIENCE)|제28권 제4호|pp. 287-297|DOI 10.7783/KJMCS.2020.28.4.287

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Traditional MedicineBangpungtongseong-sanType II Diabetes

초록

Background: Type II diabetes is considered as one of the common diseases. Bangpungtongseongsan (BPS) has been used as a traditional medicine for treating obesity and hypertension in Korea. According to previous reports, it has anti-obesity, anti-chronic asthma, anti-oxidant, and antiinflammatory properties. However, the effects of BPS on type II diabetes have not yet been elucidated. Thus, in this sutudy, we evaluated the water extracts of BPS using type II diabetes animal models. Methods and Results: Each group was orally administered with BPS (170, 850 and 1,700 ㎎/㎏) for approximately 13 weeks. A mixture of 150 ㎎/㎏ metformin and 10 ㎎/㎏ sitagliptin (MS) was used as a positive control. The glycated hemoglobin (HbA1c) and glucose levels, and hematological parameters including blood urine nitrogen, creatinine, low density lipoprotein and total cholesterol, were measured using blood samples. Treatment with 170 ㎎/㎏ BPS decreased the HbA1c and glucose levels in blood without affecting the weights of the animals. However, threatment with 1,700 ㎎/㎏ BPS reduced the weights and fatty liver, and increased the blood glucose level in type II diabetes animal models Conclusions: These results indicate that a low dose of BPS for 13 weeks, which reduces HbA1c and blood glucose levels, could be used for the treatment of type II diabetes. However, further studies are required to elucidate how active ingredients of BPS influence HbA1c and glucose levels in blood.

Abstract

Background: Type II diabetes is considered as one of the common diseases. Bangpungtongseongsan (BPS) has been used as a traditional medicine for treating obesity and hypertension in Korea. According to previous reports, it has anti-obesity, anti-chronic asthma, anti-oxidant, and antiinflammatory properties. However, the effects of BPS on type II diabetes have not yet been elucidated. Thus, in this sutudy, we evaluated the water extracts of BPS using type II diabetes animal models. Methods and Results: Each group was orally administered with BPS (170, 850 and 1,700 ㎎/㎏) for approximately 13 weeks. A mixture of 150 ㎎/㎏ metformin and 10 ㎎/㎏ sitagliptin (MS) was used as a positive control. The glycated hemoglobin (HbA1c) and glucose levels, and hematological parameters including blood urine nitrogen, creatinine, low density lipoprotein and total cholesterol, were measured using blood samples. Treatment with 170 ㎎/㎏ BPS decreased the HbA1c and glucose levels in blood without affecting the weights of the animals. However, threatment with 1,700 ㎎/㎏ BPS reduced the weights and fatty liver, and increased the blood glucose level in type II diabetes animal models Conclusions: These results indicate that a low dose of BPS for 13 weeks, which reduces HbA1c and blood glucose levels, could be used for the treatment of type II diabetes. However, further studies are required to elucidate how active ingredients of BPS influence HbA1c and glucose levels in blood.

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