New Antibacterial Peptide Analogs of 5-Aminobenzimidazoles
0
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Three new peptide analogs 5a-c were obtained through coupling of 5-Amino benzimidazoles 2a-c with L-phenylalanine. For the purpose α-amino group was blocked with phthalic anhydride and activation of α-carboxy group of phenylalanine was carried out by preparing phthaloyl-L-phenylalanyl chloride 4. After developing a successful peptide linkage, the phthaloyl group was removed by treating 5a-c with hydrazine hydrate to get free peptides 6a-c, purified through a column of Amberlite (IR-4B). All of these compounds 2a-c and 5,6a-c have been characterized on the basis of their IR, ^1H NMR and EIMS analyses. Antibacterial activity of these compounds is also been reported.
Abstract
Three new peptide analogs 5a-c were obtained through coupling of 5-Amino benzimidazoles 2a-c with L-phenylalanine. For the purpose α-amino group was blocked with phthalic anhydride and activation of α-carboxy group of phenylalanine was carried out by preparing phthaloyl-L-phenylalanyl chloride 4. After developing a successful peptide linkage, the phthaloyl group was removed by treating 5a-c with hydrazine hydrate to get free peptides 6a-c, purified through a column of Amberlite (IR-4B). All of these compounds 2a-c and 5,6a-c have been characterized on the basis of their IR, ^1H NMR and EIMS analyses. Antibacterial activity of these compounds is also been reported.
참고문헌 (24)
- Alamgir, M., , Top Heterocycle Chem, 9, pp.87~ (2007)
- Ayhan-Kilcrgil, G., , Turk. J. Chem, 30, pp.223~ (2006)
- Kruse, L. L., , J. Med. Chem, 32, pp.409~ (1989)
- Kumar, J. R., , E-Journal of Chemistry, 3(13), pp.278~ (2006)
- Werner, W., , Pharmazine, 46(2), pp.113~ (1991)
- Islam, I., , J. Med. Chem, 34, pp.2954~ (1991)
- Porcari, A. R., , J. Med. Chem, 41, pp.1252~ (1998)
- Roth, M., , J. J. Med. Chem, 40, pp.4199~ (1997)
- David, R. A., , Acta Cient Venez, 41(2), pp.88~ (1990)
- Nakano, H., , Satoh, Chem. Pharma. Bull, 47, pp.1573~ (1999)
- Goker, H., , J. Hetrocycles, 51, pp.2561~ (1999)
- Kucukguzel, I., , Biorg. Med. Chem. Letters, 11, pp.1703~ (2001)
- Ayhan-Kilcrgil, G., , Il Farmaco, 58(12), pp.1345~ (2003)
- Cresenza, A., , J. Org. Chem, 64, pp.3019~ (1999)
- Lucchese, G., , Amino Acids, 33, pp.703~ (2006)
- Milkowski, J. D., , J. Med. Chem, 13, pp.741~ (1970)
- Stone, C. A., "U.S. Patent, 4,156,734, Chem. Abstr", ~ (1979)
- Lin, L. S., , Bioorg. Med. Chem. Lett, 14, pp.2331~ (2004)
- Mcgrath, M. E., "Biochemistry 2006", Biochemistry, 45, pp.5694~ (2006)
- Malgorzata, K. R., , Amino Acids, 36, pp.309~ (2009)
- Hasan, M., , Turk. J. Chem, 24, pp.165~ (2000)
- Hassan, M., , J. Chem. Soc. Pak, 9(1), pp.65~ (1987)
- Greenstein, J. P., "Chemistry of Amino Acids, Vol. 2" (1961), John Wiley and Sons Inc
- Atta-ur-Rahman, "Bioassay Techniques for Drug Development", pp.16~ (2001), Taylor & Francis