Concurrence of Helicobacter pylori Infection and Its Associated Factors in Korean Couples
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Background: This study evaluated the prevalence of Helicobacter pylori infection and the risk factors associated with H. pylori transmission among spouses.Methods: We assessed the spousal concurrence of H. pylori infection using the Campylobacter-like organism (CLO) test under gastro-endoscopy in 132 couples. Based on the CLO test results, participants were categorized into H. pylori concurrent and independent groups. The chi-square test and Student t-test were performed for de-mographic comparisons between the concurrent and independent H. pylori groups. In addition, multivariate lo-gistic regression analysis was performed to identify factors associated with concurrent H. pylori infection.Results: The study revealed that the concurrence rate of H. pylori infection was 42.4% in married Korean couples. The odds ratio (OR) derived from the concurrence of H. pylori infection tended to decrease in older couples (OR, 0.975; 95% confidence interval [CI], 0.949–1.002; P=0.072). Gastric erosion was also associated with a decreased OR for concurrent infection (OR, 0.488; 95% CI, 0.295–0.808; P=0.005). Conversely, active duodenal ulcers were associ-ated with an increased OR for concurrent infections (OR, 6.501; 95% CI, 1.267–33.346; P=0.025). Duodenal ulcer scars tended to increase the OR of concurrent infections (OR, 1.392; 95% CI, 0.815–2.380; P=0.226).Conclusion: Spousal transmission and concurrence of H. pylori infection were negatively associated with gastric erosion; however, they were positively associated with active duodenal ulcers. Further studies are warranted to elu-cidate the mechanisms underlying these findings.
Abstract
Background: This study evaluated the prevalence of Helicobacter pylori infection and the risk factors associated with H. pylori transmission among spouses.Methods: We assessed the spousal concurrence of H. pylori infection using the Campylobacter-like organism (CLO) test under gastro-endoscopy in 132 couples. Based on the CLO test results, participants were categorized into H. pylori concurrent and independent groups. The chi-square test and Student t-test were performed for de-mographic comparisons between the concurrent and independent H. pylori groups. In addition, multivariate lo-gistic regression analysis was performed to identify factors associated with concurrent H. pylori infection.Results: The study revealed that the concurrence rate of H. pylori infection was 42.4% in married Korean couples. The odds ratio (OR) derived from the concurrence of H. pylori infection tended to decrease in older couples (OR, 0.975; 95% confidence interval [CI], 0.949–1.002; P=0.072). Gastric erosion was also associated with a decreased OR for concurrent infection (OR, 0.488; 95% CI, 0.295–0.808; P=0.005). Conversely, active duodenal ulcers were associ-ated with an increased OR for concurrent infections (OR, 6.501; 95% CI, 1.267–33.346; P=0.025). Duodenal ulcer scars tended to increase the OR of concurrent infections (OR, 1.392; 95% CI, 0.815–2.380; P=0.226).Conclusion: Spousal transmission and concurrence of H. pylori infection were negatively associated with gastric erosion; however, they were positively associated with active duodenal ulcers. Further studies are warranted to elu-cidate the mechanisms underlying these findings.
참고문헌 (18)
- Kusters JG, "Pathogenesis of Helicobacter pylori infection", Clin Microbiol Rev, 19, pp.449~490 (2006)
- Hooi JK, "Global prevalence of Helicobacter pylori infection : systematic review and meta-analysis", Gastroenterology, 153, pp.420~429 (2017)
- Graham DY, "History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancer", World J Gastroenterol, 20, pp.5191~5204 (2014)
- Magalhaes Queiroz DM, "Epidemiology of Helicobacter pylori infection", Helicobacter, 11(Suppl 1), pp.1~5 (2006)
- Delport W, "The transmission of Helicobacter pylori : the effects of analysis method and study population on inference", Best Pract Res Clin Gastroenterol, 21, pp.215~236 (2007)
- Singh V, "Helicobacter pylori : evidence for spouse-to-spouse transmission", J Gastroenterol Hepatol, 14, pp.519~522 (1999)
- Brenner H, "Active infection with Helicobacter pylori in healthy couples", Epidemiol Infect, 122, pp.91~95 (1999)
- Brenner H, "Clustering of Helicobacter pylori infection in couples : differences between high-and lowprevalence population groups", Ann Epidemiol, 16, pp.516~520 (2006)
- Stone MA, "Increased risk of infection with Helicobacter pylori in spouses of infected subjects : observations in a general population sample from the UK", Hepatogastroenterology, 47, pp.433~436 (2000)
- Sgambato D, "Prevalence of Helicobacter pylori infection in sexual partners of H. pylori-infected subjects: role of gastroesophageal reflux", United European Gastroenterol J, 6, pp.1470~1476 (2018)
- Hopkins RJ, "Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence : a review", Gastroenterology, 110, pp.1244~1252 (1996)
- Parente F, "Prevalence of Helicobacter pylori infection and related gastroduodenal lesions in spouses of Helicobacter pylori positive patients with duodenal ulcer", Gut, 39, pp.629~633 (1996)
- Hopkins RJ, "Helicobacter pylori : the missing link in perspective", Am J Med, 97, pp.265~277 (1994)
- Graham DY, "Campylobacter pylori and peptic ulcer disease", Gastroenterology, 96(2 Pt 2 Suppl), pp.615~625 (1989)
- Zhang C, "Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer", World J Gastroenterol, 11, pp.791~796 (2005)
- Maguilnik I, "Reactive gastropathy is associated with inflammatory conditions throughout the gastrointestinal tract", Aliment Pharmacol Ther, 36, pp.736~743 (2012)
- 이선영, "Endoscopic gastritis, serum pepsinogen assay, and Helicobacter pylori infection", The Korean Journal of Internal Medicine, 31(5), pp.835~844 (2016), 대한내과학회[DOI]
- Kate V, "Helicobacter pylori infection and erosive gastritis", J Assoc Physicians India, 46, pp.436~437 (1998)