본문 바로가기
KERD
논문KCI 등재

악성 종양 관련 일측성 성대 마비 환자에서 고식적 Hyaluronic Acid 성대 주입 성형술의 유용성

Benefits of Palliative Office-Based Hyaluronic Acid Injection Laryngoplasty in Cancer-Related Unilateral Vocal Cord Paralysis Patients

김상연|박영학|주영훈|심미란|황연신|선동일|김고운
대한후두음성언어의학회 (Korean Society of Laryngology, Phoniatrics and Logopedics)|2018.06|대한후두음성언어의학회지 (Journal of Korean Society of Laryngology, Phoniatrics and Logopedics)|제29권 제1호|pp. 30-36

2

조회

0

다운로드

2

인용

0

참고문헌

키워드

성대 마비악성 종양고식적 성대 주입 성형술

초록

Background and Objectives The effect of palliative injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients on voice and swallowing function is uncertain and there are few previous studies of its suitability, benefits as a palliative treatment option. The purpose of this study is to confirm the objective results of voice and swallowing function after palliative office-based hyaluronic acid injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients. Materials and Method 36 patients who had unilateral vocal cord paralysis from non-thyroidal, extralaryngeal neoplasms were included in this study. To evaluate the clinical outcome, we analyzed perceptual GRBAS grading, acoustic analysis, aerodynamic study, Electroglottography (EGG), Voice Handicap Index (VHI-30) about voice function and disability rating scale (DRS), gastric tube dependency, aspiration pneumonia about swallowing function and 36-Item Short Form Survey version 2 (SF-36v2) about quality of life. Results In GRBAS scale, G (p＜0.001), R (p=0.004), B (p=0.001), A (p=0.011), and S (p=0.007) showed significant improvement. Jitter, shimmer, speaking fundamental frequency, maximal phonation time, VHI-30, DRS score, gastric tube dependency, aspiration pneumonia, and SF-36v2 were significantly improved after injection (p=0.016, p=0.011, p=0.045, p=0.005, p＜0.001, p＜0.001 p=0.003, p＜0.001, and p＜0.001 respectively). Conclusion From this study we concluded office-based hyaluronic acid injection can be used as a useful palliative treatment option in cancer-related ill patients with unilateral vocal cord paralysis. Palliative hyaluronic acid injection laryngoplasty avoids the need for tube feeding, thus reducing the risk of aspiration pneumonia. These outcomes are accompanied by significant improvement in voice quality.

Abstract

Background and Objectives The effect of palliative injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients on voice and swallowing function is uncertain and there are few previous studies of its suitability, benefits as a palliative treatment option. The purpose of this study is to confirm the objective results of voice and swallowing function after palliative office-based hyaluronic acid injection laryngoplasty in cancer-related unilateral vocal cord paralysis patients. Materials and Method 36 patients who had unilateral vocal cord paralysis from non-thyroidal, extralaryngeal neoplasms were included in this study. To evaluate the clinical outcome, we analyzed perceptual GRBAS grading, acoustic analysis, aerodynamic study, Electroglottography (EGG), Voice Handicap Index (VHI-30) about voice function and disability rating scale (DRS), gastric tube dependency, aspiration pneumonia about swallowing function and 36-Item Short Form Survey version 2 (SF-36v2) about quality of life. Results In GRBAS scale, G (p＜0.001), R (p=0.004), B (p=0.001), A (p=0.011), and S (p=0.007) showed significant improvement. Jitter, shimmer, speaking fundamental frequency, maximal phonation time, VHI-30, DRS score, gastric tube dependency, aspiration pneumonia, and SF-36v2 were significantly improved after injection (p=0.016, p=0.011, p=0.045, p=0.005, p＜0.001, p＜0.001 p=0.003, p＜0.001, and p＜0.001 respectively). Conclusion From this study we concluded office-based hyaluronic acid injection can be used as a useful palliative treatment option in cancer-related ill patients with unilateral vocal cord paralysis. Palliative hyaluronic acid injection laryngoplasty avoids the need for tube feeding, thus reducing the risk of aspiration pneumonia. These outcomes are accompanied by significant improvement in voice quality.

참고문헌 (20)

  1. Sun DI, "Injection laryngoplasty", Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics, 24(2), pp.88~95 (2013)
  2. Benninger MS, "Evaluation and treatment of the unilateral paralyzed vocal fold", Otolaryngol Head Neck Surg, 111(4), pp.497~508 (1994)
  3. Benninger MS, "Changing etiology of vocal fold immobility", Laryngoscope, 108(9), pp.1346~1350 (1998)
  4. Soriano RG, "In-Office Hyaluronate Injection Laryngoplasty as Palliative Treatment for Unilateral Vocal Fold Paralysis", ORL J Otorhinolaryngol Relat Spec, 78(4), pp.187~192 (2016)
  5. Choi HS, "Medialization thyroplasty with silastic-decision making & practical points", Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics, 18(1), pp.7~10 (2007)
  6. Iseli TA, "Palliative surgery for neoplastic unilateral vocal cord paralysis", ANZ J Surg, 71(11), pp.672~674 (2001)
  7. Zeitels SM, "Management of common voice problems: Committee report", Otolaryngol Head Neck Surg, 126(4), pp.333~348 (2002)
  8. Billante CR, "Voice outcome following thyroplasty in patients with cancer-related vocal fold paralysis", Auris Nasus Larynx, 28(4), pp.315~321 (2001)
  9. Lam PK, "Medialization thyroplasty for cancer-related unilateral vocal fold paralysis", Otolaryngol Head Neck Surg, 136(3), pp.440~444 (2007)
  10. O’Leary MA, "Injection laryngoplasty", Otolaryngol Clin North Am, 39(1), pp.43~54 (2006)
  11. 장현, "흡인을 동반한 일측성 성대마비 환자에서 일시적 성대주입술의 역할", 대한이비인후-두경부외과학회지, 52(3), pp.237~241 (2009), 대한이비인후과학회
  12. Kwon TK, "Injection laryngoplasty for management of unilateral vocal fold paralysis", Curr Opin Otolaryngol Head Neck Surg, 12(6), pp.538~542 (2004)
  13. 김재옥, "음도 고정 유무에 따른 공기역학, 음성효율성 및 성대접촉률 차이", 말소리와 음성과학, 5(1), pp.19~26 (2013), 한국음성학회
  14. Ward ECCA, "Validity, reliability and responsivity of the Royal Brisbane Hospital Outcome Measure for Swallowing", Asia Pac J Speech Lang Hear, 4(2), pp.109~129 (1999)
  15. Nam BH, "Testing the validity of the Korean SF-36 health survey", Journal of the Korean Society of Health Statistics, 28(2), pp.3~24 (2003)
  16. Nguyen NP, "Impact of swallowing therapy on aspiration rate following treatment for locally advanced head and neck cancer", Oral Oncol, 43(4), pp.352~357 (2007)
  17. Raykher A, "Enteral nutrition support of head and neck cancer patients", Nutr Clin Pract, 22(1), pp.68~73 (2007)
  18. Woo JH BM, "Injection Laryngoplasty for The Treatment of Vocal Fold Scar, and Sulcus", Journal of The Korean Society of Laryngology, Phoniatrics and Logopedics, 27(1), pp.25~29 (2016)
  19. Martin RE, "Oropharyngeal dysphagia in esophageal cancer before and after transhiatal esophagectomy", Dysphagia, 16(1), pp.23~31 (2001)
  20. Lau DP, "Injection laryngoplasty with hyaluronic acid for unilateral vocal cord paralysis. Randomized controlled trial comparing two different particle sizes", J Voice, 24(1), pp.113~118 (2010)

관련 논문AI추천

The Investigation of Hyaluronic Acid (The Chaeum Premium No.2®) to Evaluate the Efficacy and Safety for Injection Laryngoplasty in Unilateral Vocal Cord Paralysis: A Single Center, Phase II TrialKim Min-Su, Park JunHo대한후두음성언어의학회 · 대한후두음성언어의학회지2024 · 제35권 제1호성대주입술 후 음향학적 분석결과 비교: 암의 신경 침윤으로 인한 일측성 성대마비 환자와 수술 후 발생한 일측성 성대마비 환자권순영, 백승국, 오경호, 우정수, 정광윤, 조용민, 조재구, 최현석대한후두음성언어의학회 · 대한후두음성언어의학회지2022 · 제33권 제3호Early Injection Laryngoplasty With a Long-Lasting Material in Patients With Potentially Recoverable Unilateral Vocal Fold Paralysis김학정, 손영익, 진호경, 최나연대한이비인후과학회 · Clinical and Experimental Otorhinolaryngology2019 · 제12권 제4호일측 성대마비 환자에 대해 음성치료와 성대주입술의 초기 치료 효과 비교 연구장현, 손희영, 안수연, 이창윤대한후두음성언어의학회 · 대한후두음성언어의학회지2017 · 제28권 제2호일측성 성대마비 환자에서 Cross-Linked Hyaluronic Acid Gel을이용한 성대주입술의 효과 및 안전성김관민, 손영익, 오재원, 이승원, 이현종대한이비인후과학회 · 대한이비인후과학회지 두경부외과학2005 · 제48권 제10호아시아인의 일측성 성대마비 치료에서 Calcium Hydroxyapatite의 효과권성근, 이도영, 정은재대한후두음성언어의학회 · 대한후두음성언어의학회지2018 · 제29권 제2호

이 간행물의 다른 논문 (9건)

두경부암 치료에 따라 발생한 흡인 환자에 대한 다각적 재활운동 치료정영호, 진영주pp. 5-8두경부암 환자에서 기도 흡인의 예방과 치료를 위한 수술 전략김동영, 백민관pp. 9-13두경부암 환자의 치료 전후 연하 평가김진환pp. 14-18후두초음파의 임상적 활용조우진pp. 19-23갑상선 수술 범위와 공기역학적 음성 지표 변화손희영, 김중선, 이창윤, 정희석pp. 24-29
원문 보기