Effect of Oral Supplementation with Branched-chain Amino Acid (BCAA) during Radiotherapy in Patients with Hepatocellular Carcinoma: A Double-Blind Randomized Study
1
조회
0
다운로드
0
인용
0
참고문헌
키워드
초록
Purpose The present study evaluated whether oral supplementation with a branched-chain amino acid (BCAA) improves the biochemical and amino acid profiles of liver tumor patients undergoing radiotherapy. Materials and Methods Patients were randomly assigned to one of 2 groups: a group given oral supplementation with BCAA granules (LIVACT granules; Samil Pharm Co., Korea, each granule containing Lisoleucine 952 mg, L-leucine 1,904 mg, and L-valine 1,144 mg) during radiotherapy, or a placebo group. Physical and biochemical examinations and measurements, including subjective symptoms, Child-Pugh class, body mass index, plasma albumin concentration, and plasma amino acid profiles were monitored. Results Fifty were enrolled between November 2005 and November 2006. We also analyzed data from 37 hepatocellular carcinoma (HCC) patients in order to evaluate a more homogenous group. The two groups of patients were comparable in terms of age, gender, Child-Pugh score, and underlying hepatitis virus type. Serum albumin, total protein, liver enzymes, and cholesterol showed a tendency to increase in the BCAA group. In this group, the percentage of cases that reverted to normal serum albumin levels between 3 and 10 weeks after administration of BCAA was significantly higher (41.18%) than in the placebo group (p=0.043). Conclusion Oral supplementation with a BCAA preparation seems to help HCC patients undergoing radiotherapy by increasing the BCAA concentration.
Abstract
Purpose The present study evaluated whether oral supplementation with a branched-chain amino acid (BCAA) improves the biochemical and amino acid profiles of liver tumor patients undergoing radiotherapy. Materials and Methods Patients were randomly assigned to one of 2 groups: a group given oral supplementation with BCAA granules (LIVACT granules; Samil Pharm Co., Korea, each granule containing Lisoleucine 952 mg, L-leucine 1,904 mg, and L-valine 1,144 mg) during radiotherapy, or a placebo group. Physical and biochemical examinations and measurements, including subjective symptoms, Child-Pugh class, body mass index, plasma albumin concentration, and plasma amino acid profiles were monitored. Results Fifty were enrolled between November 2005 and November 2006. We also analyzed data from 37 hepatocellular carcinoma (HCC) patients in order to evaluate a more homogenous group. The two groups of patients were comparable in terms of age, gender, Child-Pugh score, and underlying hepatitis virus type. Serum albumin, total protein, liver enzymes, and cholesterol showed a tendency to increase in the BCAA group. In this group, the percentage of cases that reverted to normal serum albumin levels between 3 and 10 weeks after administration of BCAA was significantly higher (41.18%) than in the placebo group (p=0.043). Conclusion Oral supplementation with a BCAA preparation seems to help HCC patients undergoing radiotherapy by increasing the BCAA concentration.
참고문헌 (25)
- el-Serag HB, "Epidemiology of hepatocellular carcinoma", Clin Liver Dis, 5, pp.87~107 (2001)
- (2009)[URL]
- Poon RT, "Locoregional therapies for hepatocellular carcinoma: a critical review from the surgeon's perspective", Ann Surg, 235, pp.466~486 (2002)
- Cochrane AM, "Quadruple chemotherapy versus radiotherapy in treatment of primary hepatocellular carcinoma", Cancer, 40, pp.609~615 (1977)
- Ingold JA, "Radiation hepatitis", Am J Roentgenol Radium Ther Nucl Med, 93, pp.200~208 (1965)
- Lawrence TS, "An application of dose volume histograms to the treatment of intrahepatic malignancies with radiation therapy", Int J Radiat Oncol Biol Phys, 19, pp.1041~1047 (1990)
- Emami B, "Tolerance of normal tissue to therapeutic irradiation", Int J Radiat Oncol Biol Phys, 21, pp.109~122 (1991)
- Lawrence TS, "The use of 3-D dose volume analysis to predict radiation hepatitis", Int J Radiat Oncol Biol Phys, 23, pp.781~788 (1992)
- Robertson JM, "A phase I trial of hepatic arterial bromodeoxyuridine and conformal radiation therapy for patients with primary hepatobiliary cancers or colorectal liver metastases", Int J Radiat Oncol Biol Phys, 39, pp.1087~1092 (1997)
- Seong J, "Combined transcatheter arterial chemoembolization and local radiotherapy of unresectable hepatocellular carcinoma", Int J Radiat Oncol Biol Phys, 43, pp.393~397 (1999)
- Park W, "Local radiotherapy for patients with unresectable hepatocellular carcinoma", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 61, pp.1143~1150 (2005), ELSEVIER SCIENCE INC
- Shim SJ, "Local radiotherapy as a complement to incomplete transcatheter arterial chemoembolization in locally advanced hepatocellular carcinoma", LIVER INTERNATIONAL, 25, pp.1189~1196 (2005), BLACKWELL PUBLISHING
- 이익재, "간세포암종의 방사선치료 시 발생하는 간독성에 대한 위험인자의 재고찰", Clinical and Molecular Hepatology, 12(3), pp.420~428 (2006), 대한간학회
- Cheng JC, "Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description", Radiother Oncol, 63, pp.41~45 (2002)
- Liang SX, "Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance", Int J Radiat Oncol Biol Phys, 65, pp.426~434 (2006)
- Nompleggi DJ, "Nutritional supplementation in chronic liver disease: an analytical review", Hepatology, 19, pp.518~533 (1994)
- Fan ST, "Perioperative nutritional support in patients undergoing hepatectomy for hepatocellular carcinoma", N Engl J Med, 331, pp.1547~1552 (1994)
- Meng WC, "Prospective randomized control study on the effect of branched-chain amino acids in patients with liver resection for hepatocellular carcinoma", Aust N Z J Surg, 69, pp.811~815 (1999)
- Muto Y, "Effect of oral administration with branched-chain amino acid granules (BCAA-G) in patients with liver cirrhosis: a clinical study", JJPEN, 11, pp.1119~1134 (1989)
- Lee IJ, "RADIOTHERAPEUTIC PARAMETERS PREDICTIVE OF LIVER COMPLICATIONS INDUCED BY LIVER TUMOR RADIOTHERAPY", INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 73(1), pp.154~158 (2009)
- Marchesini G, "Nutritional supplementation with branched-chain amino acids in advanced cirrhosis: a doubleblind, randomized trial", Gastroenterology, 124, pp.1792~1801 (2003)
- Song KH, "Prospective study on efficacy of oral supplement of branched-chain amino acid granules on the nutritional status of the cirrhotics", Korean J Hepatol, 7, pp.432~438 (2001)
- Nijveldt RJ, "Major liver resection results in a changed plasma amino acid pattern as reflected by a decreased Fischer ratio which improves by bactericidal", permeability increasing protein, 2001, pp.21, 56~63
- Togo S, "Usefulness of granular BCAA after hepatectomy for liver cancer complicated with liver cirrhosis", Nutrition, 21, pp.480~486 (2005)
- Poon RT, "Long-term oral branched chain amino acids in patients undergoing chemoembolization for hepatocellular carcinoma: a randomized trial", Aliment Pharmacol Ther, 19, pp.779~788 (2004)